EFFECTS OF OZONE THERAPY ON PAIN RELIEF IN PATIENTS WITH LOW BACK PAIN: CASE SERIES.

Abstract

Ozone therapy is an integrative, complementary modality that employs a gas mixture composed of ozone at concentrations of up to 5 % and medical-grade oxygen (O₂) at up to 95 %. Because it is minimally invasive and associated with only rare complications, it represents a viable adjunct for several clinical situations, including immunomodulation, inflammatory disorders, metabolic dysfunctions and pain syndromes, particularly sciatica, by triggering endorphin release, activating analgesic pathways and reducing prostaglandin synthesis.

This study aimed to evaluate the effects of ozone therapy in nine patients with sciatic nerve pain caused by lumbar disc herniation (lumbosciatica). We conducted a prospective study enrolling nine individuals with sciatica. The protocol was approved by the Research Ethics Committee of Centro Universitário de Rio Preto (approval no. 5.543.403). Ozone therapy, administered subcutaneously and rectally, was used as an adjunct to each participant’s standard treatment. Data collection included clinical characteristics, medical diagnoses, laboratory test results and concomitant medication use.