Use of Tranexamic Acid in the Control of Postoperative Bleeding in Oral Surgery: A Narrative Review of the Literature

Authors

  • Maria Clara Casanova de Carvalho Meireles Uninassau
  • Alline Gisele das Neves
  • Letícia Evelyn de Azevedo Leite
  • Karla Emanuelly Alves Nunes
  • Gustavo Henrique Amorim da Silva
  • Samuel Phelipe Rodrigues dos Santos
  • Álison da Silva Santos
  • Daniela Ferreira de Freitas Vieira
  • Alesson Jamesson da Silva

DOI:

https://doi.org/10.36557/2674-8169.2025v7n10p1009-1020

Keywords:

Tranexamic, Acid, Oral, surgery, Hemostasis, Postoperative, Dentistry

Abstract

Bleeding control represents one of the main challenges in oral surgery, especially in patients with systemic disorders or those taking anticoagulants. Tranexamic acid, an antifibrinolytic agent, has been identified as an efficient and safe alternative for reducing postoperative bleeding complications. This narrative review aims to gather and discuss the scientific evidence related to the use of tranexamic acid in surgical dental procedures, addressing its mechanisms of action, administration methods, benefits, and limitations. The literature indicates that topical application, whether through mouthwashes or compresses, presents promising results in hemostatic control, constituting an especially useful adjuvant resource in high-risk patients. We conclude that incorporating tranexamic acid into dental protocols can significantly contribute to clinical safety, although larger, long-term research is needed.            

Downloads

Download data is not yet available.

References

AMARAL, J. A.; OLIVEIRA, M. S. Uso do ácido tranexâmico em odontologia: revisão de literatura. Revista Brasileira de Odontologia, v. 79, n. 1, p. 45-52, 2022.

CARTER, G.; GASSER, C.; HOFMANN, U. Tranexamic acid mouthwash in oral surgery patients on anticoagulants. British Journal of Oral and Maxillofacial Surgery, v. 41, p. 21-25, 2021.

HENRIQUES, F. R.; LIMA, A. R.; SOUZA, P. C. Aplicação tópica de ácido tranexâmico em cirurgia oral: revisão narrativa. Journal of Dentistry and Oral Health, v. 12, n. 3, p. 89-96, 2020.

PATEL, J. P.; GREEN, B.; CHATHA, J. The use of tranexamic acid in dentistry: a systematic review. International Journal of Oral and Maxillofacial Surgery, v. 50, n. 5, p. 567-574, 2021. WORLD HEALTH ORGANIZATION (WHO). Tranexamic acid: uses and recommendations.

Geneva: WHO, 2023.

PACHECO, Rafael Leite; SILVEIRA, Vicente Penido da; SUETSUGU, Rodrigo Cesar de Sá; MALTONI, Isabela Soucin; SILVA, Diego Adão Fanti; RIERA, Rachel. Evidências de revisões sistemáticas Cochrane sobre o uso do ácido tranexâmico em pacientes submetidos a cirurgia. Diagnóstico & Tratamento, São Paulo, v. 19, n. 2, p. 87-90, abr./jun. 2014.

CARTER, G. Tranexamic acid mouthwash — a prospective randomized study of a 2-day regimen vs 5-day regimen to prevent postoperative bleeding in anticoagulated patients requiring dental extractions. Journal of Oral and Maxillofacial Surgery, v. 61, n. 12, p. 1432–1435, 2003.

OCKERMAN, A. et al. The EXTRACT-NOAC randomized clinical trial: Tranexamic acid and bleeding in patients treated with non-vitamin K oral anticoagulants undergoing dental extraction. PLOS Medicine, v. 18, n. 7, p. e1003764, 2021.

ROBERTS, I. Wider use of tranexamic acid to reduce surgical bleeding. BMJ, v. 384, p. 1–2, 2024.

ZAIB, A. et al. Local tranexamic acid for preventing hemorrhage in anticoagulated patients undergoing oral surgery: systematic review/meta-analysis and clinical implications. Healthcare, v. 10, n. 12, p. 2389, 2022.

PACHECO, Rafael Leite; SILVEIRA, Vicente Penido da; SUETSUGU, Rodrigo Cesar de Sá; MALTONI, Isabela Soucin; SILVA, Diego Adão Fanti; RIERA, Rachel. Evidências de revisões sistemáticas Cochrane sobre o uso do ácido tranexâmico em pacientes submetidos a cirurgia. Diagnóstico & Tratamento, São Paulo, v. 19, n. 2, p. 87-90, abr./jun. 2014.

Published

2025-10-16

How to Cite

Casanova de Carvalho Meireles, M. C., Gisele das Neves, A., Evelyn de Azevedo Leite, L., Emanuelly Alves Nunes, K., Henrique Amorim da Silva, G., Phelipe Rodrigues dos Santos, S., da Silva Santos, Álison, Ferreira de Freitas Vieira, D., & Jamesson da Silva, A. (2025). Use of Tranexamic Acid in the Control of Postoperative Bleeding in Oral Surgery: A Narrative Review of the Literature. Brazilian Journal of Implantology and Health Sciences, 7(10), 1009–1020. https://doi.org/10.36557/2674-8169.2025v7n10p1009-1020