Persistência tecidual e complicações tardias associadas a preenchedores à base de ácido hialurônico: uma revisão integrativa
DOI:
https://doi.org/10.36557/2674-8169.2026v8n9p129-177Palavras-chave:
Ácido hialurônico., Preenchedores dérmicos., Persistência tecidual., Granuloma de corpo estranho., Reações inflamatórias tardias.Resumo
Introdução: Os preenchedores à base de ácido hialurônico (AH) são amplamente utilizados em procedimentos estéticos e, embora sejam considerados biodegradáveis, evidências recentes têm demonstrado que o material pode permanecer nos tecidos por períodos superiores aos tradicionalmente esperados, levantando questões acerca de seu comportamento e de possíveis complicações em longo prazo. Objetivo: Analisar as evidências disponíveis acerca da persistência prolongada e da presença de resíduos teciduais de preenchedores à base de AH, bem como das reações granulomatosas e demais manifestações inflamatórias tardias associadas ao seu uso. Metodologia: Trata-se de uma revisão integrativa da literatura, de caráter descritivo. A busca foi realizada em janeiro de 2026 nas bases PubMed, MEDLINE e LILACS, contemplando estudos publicados entre janeiro de 2022 e janeiro de 2026. Foram identificados 407 registros e, após a remoção de duplicatas, triagem por títulos e resumos e avaliação dos textos completos segundo os critérios de elegibilidade, 23 estudos constituíram a amostra final. Os achados foram analisados de forma descritiva e comparativa e organizados em três eixos temáticos. Resultados e Discussão: Os estudos demonstraram que preenchedores de AH podem permanecer detectáveis nos tecidos por períodos superiores a dois anos e, em determinados casos, por mais de uma década. As reações granulomatosas apresentaram ampla variabilidade temporal e diferentes padrões histopatológicos, incluindo granulomas de corpo estranho associados ao material de preenchimento. As manifestações inflamatórias tardias compreenderam principalmente edema, nódulos e reações de hipersensibilidade, com relatos temporalmente associados à infecção ou vacinação contra SARS-CoV-2, além de outros possíveis eventos desencadeantes. Considerações finais: As evidências indicam que a permanência tecidual dos preenchedores de AH pode ser substancialmente mais prolongada do que tradicionalmente considerada e que as complicações tardias apresentam natureza heterogênea e multifatorial. Entretanto, a presença de material residual não implica, isoladamente, condição patológica, e as evidências disponíveis ainda são insuficientes para estabelecer a ocorrência e a relevância clínica de um possível efeito cumulativo decorrente de aplicações sucessivas. Estudos prospectivos e longitudinais são necessários para esclarecer a dinâmica de degradação, a persistência após reaplicações e sua eventual relação com complicações tardias.
Downloads
Referências
KOBAYASHI, Takashi; CHANMEE, Theerawut; ITANO, Naoki. Hyaluronan: metabolism and function. Biomolecules, v. 10, n. 11, art. 1525, 2020. DOI: 10.3390/biom10111525.
MALAISSE, Jérémy; BOURGUIGNON, Virginie; DE VUYST, Evelyne; LAMBERT DE ROUVROIT, Catherine; NIKKELS, Arjen F.; FLAMION, Bruno; POUMAY, Yves. Hyaluronan metabolism in human keratinocytes and atopic dermatitis skin is driven by a balance of hyaluronan synthases 1 and 3. Journal of Investigative Dermatology, v. 134, n. 8, p. 2174–2182, 2014. DOI: 10.1038/jid.2014.147.
CHYLIŃSKA, Natalia; MACIEJCZYK, Mateusz. Hyaluronic acid and skin: its role in aging and wound-healing processes. Gels, v. 11, n. 4, art. 281, 2025. DOI: 10.3390/gels11040281.
TEZEL, Ahmet; FREDRICKSON, Glenn H. The science of hyaluronic acid dermal fillers. Journal of Cosmetic and Laser Therapy, v. 10, n. 1, p. 35–42, 2008. DOI: 10.1080/14764170701774901.
MATARASSO, Seth L.; CARRUTHERS, Jean D.; JEWELL, Mark L.; RESTYLANE CONSENSUS GROUP. Consensus recommendations for soft-tissue augmentation with nonanimal stabilized hyaluronic acid (Restylane). Plastic and Reconstructive Surgery, v. 117, n. 3 Suppl., p. 3S–34S, 2006. DOI: 10.1097/01.prs.0000204759.76865.39.
BEASLEY, Karen L.; WEISS, Margaret A.; WEISS, Robert A. Hyaluronic acid fillers: a comprehensive review. Facial Plastic Surgery, v. 25, n. 2, p. 86–94, 2009. DOI: 10.1055/s-0029-1220647.
BRASIL. Agência Nacional de Vigilância Sanitária. Resolução-RE nº 3.456, de 5 de agosto de 2011. Brasília, DF: Agência Nacional de Vigilância Sanitária, 2011. Disponível em: Biblioteca Virtual em Saúde do Ministério da Saúde. Acesso em: 12 fevereiro. 2026.
BRASIL. Agência Nacional de Vigilância Sanitária. Anvisa recomenda: preenchedores dérmicos somente dentro das indicações aprovadas. Brasília, DF: Anvisa, 12 mar. 2026. Disponível em: Agência Nacional de Vigilância Sanitária. Acesso em: 12 fevereiro. 2026.
HEYDENRYCH, Izolda; DE BOULLE, Koenraad; KAPOOR, Krishan Mohan; BERTOSSI, Dario. The 10-point plan 2021: updated concepts for improved procedural safety during facial filler treatments. Clinical, Cosmetic and Investigational Dermatology, v. 14, p. 779–814, 2021. DOI: 10.2147/CCID.S315711.
FAIVRE, Jimmy; PIGWEH, Amos I.; IEHL, Julien; MAFFERT, Pauline; GOEKJIAN, Peter; BOURDON, François. Crosslinking hyaluronic acid soft-tissue fillers: current status and perspectives from an industrial point of view. Expert Review of Medical Devices, v. 18, n. 12, p. 1175–1187, 2021. DOI: 10.1080/17434440.2021.2014320.
PLUDA, Stefano; SALVAGNINI, Cecilia; FONTANA, Anna; MARCHETTI, Anna; DI LUCIA, Alba; GALESSO, Devis; GUARISE, Cristian. Investigation of crosslinking parameters and characterization of hyaluronic acid dermal fillers: from design to product performances. Gels, v. 9, n. 9, art. 733, 2023. DOI: 10.3390/gels9090733
HONG, Gi-Woong; WAN, Jovian; CHANG, Kathleen; PARK, Youngjin; YI, Kyu-Ho. Decomposition and changes in in vivo post-HA filler injection: a review. Journal of Cosmetic Dermatology, v. 24, n. 1, e16652, 2025. DOI: 10.1111/jocd.16652
MASTER, Mobin; AZIZEDDIN, Arshia; MASTER, Vahid. Hyaluronic acid filler longevity in the mid-face: a review of 33 magnetic resonance imaging studies. Plastic and Reconstructive Surgery – Global Open, v. 12, n. 7, e5934, 2024. DOI: 10.1097/GOX.0000000000005934
PAGE, Matthew J.; MCKENZIE, Joanne E.; BOSSUYT, Patrick M.; BOUTRON, Isabelle; HOFFMANN, Tammy C.; MULROW, Cynthia D.; SHAMSEER, Larissa; TETZLAFF, Jennifer M.; AKL, Elie A.; BRENNAN, Sue E.; CHOU, Roger; GLANVILLE, Julie; GRIMSHAW, Jeremy M.; HRÓBJARTSSON, Asbjorn; LALU, Manoj M.; LI, Tianjing; LODER, Elizabeth W.; MAYO-WILSON, Evan; MCDONALD, Steve; MCGUINNESS, Luke A.; STEWART, Lesley A.; THOMAS, James; TRICCO, Andrea C.; WELCH, Vivian A.; WHITING, Penny; MOHER, David. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, v. 372, n71, 2021. DOI: 10.1136/bmj.n71.
MASTER, Mobin; ROBERTS, Stefania. Long-term MRI follow-up of hyaluronic acid dermal filler. Plastic and Reconstructive Surgery – Global Open, v. 10, n. 4, e4252, 2022. DOI: 10.1097/GOX.0000000000004252.
KALMANSON, Olivia A.; MISCH, Emily S.; TERELLA, Adam. Hyaluronic acid fillers may be longer-lasting than previously described: a case report of delayed filler-associated facial cellulitis. JPRAS Open, v. 33, p. 37–41, 2022. DOI: 10.1016/j.jpra.2022.05.011.
LAI, Dihui; LIU, Hongmei; KONG, Linghong; CHENG, Shaowei. Delayed complication of botulinum toxin and hyaluronic acid filler injections: a case report. Journal of Cosmetic Dermatology, v. 21, n. 6, p. 2374–2378, 2022. DOI: 10.1111/jocd.15016.
RIVERS, Jason K. Incidence and treatment of delayed-onset nodules after VYC filler injections to 2139 patients at a single Canadian clinic. Journal of Cosmetic Dermatology, v. 21, n. 6, p. 2379–2386, 2022. DOI: 10.1111/jocd.15013
MICHEL, Jonathan C.; PERENACK, Jon D.; CHAPPLE, Andrew G. Are delayed dermal filler granulomas more common since COVID-19? Journal of Oral and Maxillofacial Surgery, v. 81, n. 1, p. 42–48, 2023. DOI: 10.1016/j.joms.2022.09.011.
HWANG, Ming-Jay; LEE, Yi-Pang; JIN, Ying-Tai; CHIANG, Chun-Pin. Hyaluronic acid-induced foreign body granuloma in the upper lip. Journal of Dental Sciences, v. 18, n. 3, p. 1429–1430, 2023. DOI: 10.1016/j.jds.2023.04.005
NISHIMURA, Michiko; SAKAMOTO, Shinnichi; HOSHINO, Miyako; MIYAZAKI, Yuji; YAMAMOTO, Junichiro; SAKASHITA, Hideaki; KUSAMA, Kaoru; KIKUCHI, Kentaro. Histological features of delayed foreign body granuloma with epithelioid histiocyte aggregation and eosinophilic reaction due to hyaluronic acid injection. Case Reports in Dentistry, v. 2024, art. 5565324, 2024. DOI: 10.1155/crid/5565324.
ALMADAN, Nasser; ALTHUBAITI, Reem; UGURU, Chibuzo; POTHANIKAT, Joseph John K.; ALSHAMARI, Jamal Hamed. Exuberant delayed granulomatous reaction to hyaluronic acid filler material. Journal of Surgical Case Reports, v. 2025, n. 6, rjaf395, 2025. DOI: 10.1093/jscr/rjaf395.
TETZNER, Ana Cristina; VIANA, Laura Regina Mendes; ABREU, Lucas Guimarães; MENDONÇA, Elismauro Francisco; ARANTES, Diego Antônio Costa; VASCONCELOS, Ana Carolina Uchoa; GOMES, Ana Paula Negreiros Nunes; NONAKA, Cassiano Francisco Weege; ALVES, Paulo Márcio; TAPIA, Ricardo Octávio de Castro; MESQUITA, Ricardo Alves; DE SOUSA, Soraia Fátima; SILVA, Tarcília Aparecida; CALDEIRA, Patrícia Carlos. Adverse reactions to cosmetic fillers in the oral and maxillofacial region: clinico-pathological, histochemical, and immunohistochemical characterization. Journal of Oral Pathology & Medicine, v. 54, n. 3, p. 141–150, 2025. DOI: 10.1111/jop.13604.
ORTIGOSA, Luciena Cegatto Martins; LENZONI, Fabiano Carvalho; SUÁREZ, Maria Victória; DUARTE, Artur Antônio; PRESTES-CARNEIRO, Luiz Euribel. Hypersensitivity reaction to hyaluronic acid dermal filler after COVID-19 vaccination: a series of cases in São Paulo, Brazil. International Journal of Infectious Diseases, v. 116, p. 268–270, 2022. DOI: 10.1016/j.ijid.2022.01.024.
CALVISI, Lucia. Hyaluronic acid delayed inflammatory reaction after third dose of SARS-CoV-2 vaccine. Journal of Cosmetic Dermatology, v. 21, n. 6, p. 2315–2317, 2022. DOI: 10.1111/jocd.14970.
DUA, Aman; BHARDWAJ, Bhawna. Delayed onset nodules after hyaluronic acid fillers: a case series. Journal of Cutaneous and Aesthetic Surgery, v. 15, n. 1, p. 91–94, 2022. DOI: 10.4103/JCAS.JCAS_200_20.
BEAMISH, Ian V.; BOGOCH, Isaac I.; CARR, David. Delayed inflammatory reaction to dermal fillers after COVID-19 vaccination: a case report. Canadian Journal of Emergency Medicine, v. 24, n. 4, p. 444–446, 2022. DOI: 10.1007/s43678-022-00289-x.
SAFIR, Ari; SAMUELOV, Liat; SPRECHER, Eli; DANIELY, Danny; ARTZI, Ofir. Association between BNT162b2 vaccination and the development of delayed inflammatory reactions to hyaluronic acid-based dermal fillers: a nationwide survey. Journal of Cosmetic Dermatology, v. 21, n. 10, p. 4107–4113, 2022. DOI: 10.1111/jocd.15260
MUNAVALLI, Girish Gilly; GUTHRIDGE, Rachel; KNUTSEN-LARSON, Siri; BRODSKY, Amy; MATTHEW, Ethan; LANDAU, Marina. COVID-19/SARS-CoV-2 virus spike protein-related delayed inflammatory reaction to hyaluronic acid dermal fillers: a challenging clinical conundrum in diagnosis and treatment. Archives of Dermatological Research, v. 314, n. 1, p. 1–15, 2022. DOI: 10.1007/s00403-021-02190-6.
NEAMATALLAH, Thikryat. Delayed inflammatory reaction to hyaluronic acid lip filler after the Pfizer-BioNTech COVID-19 vaccine: a case report. Heliyon, v. 9, n. 7, e18274, 2023. DOI: 10.1016/j.heliyon.2023.e18274.
MENDOZA-GÁLVEZ, Patricio; DEL RIO-MARTINEZ, Christopher Jesús; HOLGUÍN-MONTAÑO, Victoria; SANTOS-FLORES, Marcela. Delayed hypersensitivity reaction after hyaluronic acid filler (VCY-20). Dermatology Reports, v. 16, n. 2, art. 9800, 2024. DOI: 10.4081/dr.2023.9800.
CIARAMICOLO, Nathaly de Oliveira; BISSON, Gabriela Barbosa; PIEDADE, Emanuela de Fatima da Silva; FERREIRA JUNIOR OSNY. Late facial edema after lip filling with hyaluronic acid: possible association with the use of Ozempic. Journal of Craniofacial Surgery, v. 35, n. 7, p. 2110–2112, 2024. DOI: 10.1097/SCS.0000000000010588.
ALGHAMDI, Nada J.; ALMUHAIDIB, Serene R.; ALHARBI, Abdulmajeed S.; ALJALFAN, Abdullah Ali N.; AL-HUSAIN, Khalid M. Delayed inflammatory reaction to hyaluronic acid dermal filler following zoledronic acid administration: a case report. Clinical, Cosmetic and Investigational Dermatology, v. 17, p. 1347–1350, 2024. DOI: 10.2147/CCID.S458750.
REZENDE, Frederico França; CARVALHO, Isadora Vilaça; ASSIS, Luisa Murakami de; KELLER, Raquel. Hypersensitivity reaction to hyaluronic acid dermal filler concomitant with coronavirus infection: case report. Surgical & Cosmetic Dermatology, v. 16, p. 1–4, 2024.
NANDA, Rahul; COVONE, Jason; COHEN, Joel L. Delayed inflammatory reactions to hyaluronic acid fillers: a case series of novel associations. Journal of Drugs in Dermatology, v. 24, n. 1, p. 101–103, 2025. DOI: 10.36849/JDD.8468.
ENRIGHT, Kaitlyn M.; KHOURI, Lucie; NGUYEN, Quynh; ZANETTI, Kiana; BERNSTEIN, Steven; NIKOLIS, Andreas. Long-term management of recurrent biofilms in the tear trough regions following hyaluronic acid filler treatment. JAAD Case Reports, v. 60, p. 7–10, 2025. DOI: 10.1016/j.jdcr.2025.01.036.
CHOW, Kingsley V.; URMAN, Danielle S.; CABRAL, Erik S.; SHIM, Elisabeth K.; BENNETT, Richard G. Hyaluronic acid filler incidentally found during Mohs micrographic surgery: observations in 36 patients regarding skin depth, degradation size, and estimated persistence time. Dermatologic Surgery, v. 48, n. 4, p. 401–405, 2022. DOI: 10.1097/DSS.0000000000003380.
NARINS, Rhoda S.; BRANDT, Fredric S.; DAYAN, Steven H.; HORNFELDT, Carl S. Persistence of nasolabial fold correction with a hyaluronic acid dermal filler with retreatment: results of an 18-month extension study. Dermatologic Surgery, v. 37, n. 5, p. 644–650, 2011. DOI: 10.1111/j.1524-4725.2010.01863.x.
KABLIK, Jeffrey; MONHEIT, Gary D.; YU, Liping; CHANG, Grace; GERSHKOVICH, Julia. Comparative physical properties of hyaluronic acid dermal fillers. Dermatologic Surgery, v. 35, supl. 1, p. 302–312, 2009. DOI: 10.1111/j.1524-4725.2008.01046.x.
FALCONE, Samuel J.; BERG, Richard A. Crosslinked hyaluronic acid dermal fillers: a comparison of rheological properties. Journal of Biomedical Materials Research Part A, v. 87A, n. 1, p. 264–271, 2008. DOI: 10.1002/jbm.a.31675.
GERBER, Peter Arne; BUHREN, Bettina A.; BÖLKE, Edwin; PHILIPP-DORMSTON, Wolfgang G.; HOMEY, Bernhard; SCHRUMPF, Holger. Time- and dose-dependent effects of hyaluronidase on the degradation of different hyaluronan-based fillers in vitro. Plastic and Reconstructive Surgery, v. 151, n. 3, p. 560–567, 2023. DOI: 10.1097/PRS.0000000000009916.
SHUMATE, Garrett T.; CHOPRA, Rajesh; JONES, Derek; MESSINA, Darin J.; HEE, Christopher K. In vivo degradation of crosslinked hyaluronic acid fillers by exogenous hyaluronidases. Dermatologic Surgery, v. 44, n. 8, p. 1075–1083, 2018. DOI: 10.1097/DSS.0000000000001525.
PARK, Sunyoung; PARK, Kui Young; YEO, In Kwon; CHO, Sung Yeon; AH, Young Chang; KOH, Hyun Ju; PARK, Won Seok; KIM, Beom Joon. Investigation of the degradation-retarding effect caused by the low swelling capacity of a novel hyaluronic acid filler developed by solid-phase crosslinking technology. Annals of Dermatology, v. 26, n. 3, p. 357–362, 2014. DOI: 10.5021/ad.2014.26.3.357.
JONES, Derek; TEZEL, Ahmet; BJORNSDOTTIR, Sigridur; HEE, Christopher K. Quantifying the digestion of cross-linked hyaluronic acid fillers with hyaluronidase. Dermatologic Surgery, v. 47, 2021. DOI: 10.1097/DSS.0000000000003120.
MOCHIZUKI, Masato; AOI, Noriyuki; GONDA, Koichi; HIRABAYASHI, Shinichi; KOMURO, Yuzo. Evaluation of the In Vivo Kinetics and Biostimulatory Effects of Subcutaneously Injected Hyaluronic Acid Filler. Plastic and Reconstructive Surgery, v. 142, n. 1, p. 112–121, 2018. DOI: 10.1097/PRS.0000000000004496.
TURLIER, Virginie; DELALLEAU, Alexandre; CASAS, Christiane; ROUQUIER, Amandine; BIANCHI, Pascale; ALVAREZ, Sandrine; JOSSE, Gwendal; BRIANT, Alain; DAHAN, Serge; SAINT-MARTORY, Christine; THEUNIS, Jennifer; BENSAFI-BENAAOUDA, Amel; DEGOUY, Arnaud; SCHMITT, Anne-Marie; REDOULÈS, Daniel. Association between collagen production and mechanical stretching in dermal extracellular matrix: in vivo effect of cross-linked hyaluronic acid filler. A randomised, placebo-controlled study. Journal of Dermatological Science, v. 69, n. 3, p. 187–194, 2013. DOI: 10.1016/j.jdermsci.2012.12.006.
GRIMES, Pearl E.; THOMAS, Jane A.; MURPHY, Deborah K. Safety and effectiveness of hyaluronic acid fillers in skin of color. Journal of Cosmetic Dermatology, v. 8, n. 3, p. 162–168, 2009. DOI: 10.1111/j.1473-2165.2009.00457.x.
URDIALES-GÁLVEZ, Fernando; BARRES-CABALLER, Jordán; CARRASCO-SÁNCHEZ, Sara. Ultrasound assessment of tissue integration of the crosslinked hyaluronic acid filler VYC-25L in facial lower-third aesthetic treatment: a prospective multicenter study. Journal of Cosmetic Dermatology, v. 20, n. 5, p. 1439–1449, 2021. DOI: 10.1111/jocd.13632.
NARINS, Rhoda S.; DAYAN, Steven H.; BRANDT, Fredric S.; BALDWIN, Edward K. Persistence and Improvement of Nasolabial Fold Correction with Nonanimal-Stabilized Hyaluronic Acid 100,000 Gel Particles/mL Filler on Two Retreatment Schedules: Results up to 18 Months on Two Retreatment Schedules. Dermatologic Surgery, v. 34, supl. 1, p. S2–S8, 2008. DOI: 10.1111/j.1524-4725.2008.34236.x.
ZHANG, Fang Fei; XU, Zhi Xiu; CHEN, Yan. Delayed foreign body granulomas in the orofacial region after hyaluronic acid injection. Chinese Journal of Dental Research, v. 23, n. 4, p. 289–296, 2020. DOI: 10.3290/j.cjdr.b867893.
MACHADO, Renato Assis; OLIVEIRA, Lilianny Querino Rocha de; MARTELLI-JÚNIOR, Hercílio; PIRES, Fábio Ramoa; CARVAS, Janaína Badin; ROGERIO, Victor Edson; RABELO, Viviane de Azevedo; COLETTA, Ricardo Della. Adverse reactions to the injection of face and neck aesthetic filling materials: a systematic review. Medicina Oral, Patología Oral y Cirugía Bucal, v. 28, n. 3, p. e278–e284, 2023. DOI: 10.4317/medoral.25713.
LEE, Jeong Min; KIM, Yu Jin. Foreign body granulomas after the use of dermal fillers: pathophysiology, clinical appearance, histologic features, and treatment. Archives of Plastic Surgery, v. 42, n. 2, p. 232–239, 2015. DOI: 10.5999/aps.2015.42.2.232.
EVERSOLE, Roy; TRAN, Khahn; HANSEN, Doyle; CAMPBELL, John. Lip augmentation dermal filler reactions, histopathologic features. Head and Neck Pathology, v. 7, n. 3, p. 241–249, 2013. DOI: 10.1007/s12105-013-0436-1.
MODARRESSI, Ali; NIZET, Christophe; LOMBARDI, Tommaso. Granulomas and nongranulomatous nodules after filler injection: different complications require different treatments. Journal of Plastic, Reconstructive & Aesthetic Surgery, v. 73, n. 11, p. 2010–2015, 2020. DOI: 10.1016/j.bjps.2020.08.012.
CECCHI, Rossana; SPOTA, Andrea; FRATI, Paola; MUCIACCIA, Barbara. Migrating granulomatous chronic reaction from hyaluronic acid skin filler (Restylane): review and histopathological study with histochemical stainings. Dermatology, v. 228, n. 1, p. 14–17, 2014. DOI: 10.1159/000356421.
LEE, Won; SHAH-DESAI, Sabrina; RHO, Nark-Kyoung; CHO, Jeongmok. Etiology of delayed inflammatory reaction induced by hyaluronic acid filler. Archives of Plastic Surgery, v. 51, n. 1, p. 20–26, 2024. DOI: 10.1055/a-2184-6554.
BARANSKA-RYBAK, Wioletta; LAJO-PLAZA, José V.; WALKER, Lee; ALIZADEH, Navid. Late-onset reactions after hyaluronic acid dermal fillers: a consensus recommendation on etiology, prevention and management. Dermatology and Therapy, v. 14, n. 7, p. 1767–1785, 2024. DOI: 10.1007/s13555-024-01202-3.
ALIJOTAS-REIG, Jaume; GARCÍA-GIMÉNEZ, Vicente. Delayed immune-mediated adverse effects related to hyaluronic acid and acrylic hydrogel dermal fillers: clinical findings, long-term follow-up and review of the literature. Journal of the European Academy of Dermatology and Venereology, v. 22, n. 2, p. 150–161, 2008. DOI: 10.1111/j.1468-3083.2007.02354.x.
SADASHIVAIAH, Anitha B.; MYSORE, Venkataram. Biofilms: their role in dermal fillers. Journal of Cutaneous and Aesthetic Surgery, v. 3, n. 1, p. 20–22, 2010. DOI: 10.4103/0974-2077.63257.
IMEN, Mehri Turki. Delayed infectious reactions of dermal filler injections in the face: causes and management. Journal of Stomatology, Oral and Maxillofacial Surgery, v. 124, n. 2, art. 101334, 2023. DOI: 10.1016/j.jormas.2022.11.010.
DAIRI, Motaz; SAWAN, Sami; AREF, Alaa; HELMI, Noof; ABDULMAJED, Hind; ALDIGS, Eman. Post-injection syringe bacterial contamination of hyaluronic acid fillers. Journal of Cosmetic Dermatology, v. 20, n. 10, p. 3165–3168, 2021. DOI: 10.1111/jocd.14340.
GHISLANZONI, M.; BIANCHI, F.; BARBARESCHI, M.; ALESSI, E. Cutaneous granulomatous reaction to injectable hyaluronic acid gel. British Journal of Dermatology, v. 154, n. 4, p. 755–758, 2006. DOI: 10.1111/j.1365-2133.2005.07074.x.
CHUNG, King Lueh; CONVERY, Cormac; EJIKEME, Ifeoma; GHANEM, Ali M. A systematic review of the literature of delayed inflammatory reactions after hyaluronic acid filler injection to estimate the incidence of delayed type hypersensitivity reaction. Aesthetic Surgery Journal, v. 40, n. 5, p. NP286–NP300, 2020. DOI: 10.1093/asj/sjz222.
BHOJANI-LYNCH, Tahera. Late-onset inflammatory response to hyaluronic acid dermal fillers. Plastic and Reconstructive Surgery – Global Open, v. 5, n. 12, e1532, 2017. DOI: 10.1097/GOX.0000000000001532.
PHILIPP-DORMSTON, Wolfgang G. et al. Global approaches to the prevention and management of delayed-onset adverse reactions with hyaluronic acid-based fillers. Plastic and Reconstructive Surgery – Global Open, v. 8, n. 4, e2730, 2020. DOI: 10.1097/GOX.0000000000002730.
ARTZI, Ofir et al. Delayed inflammatory reactions to hyaluronic acid fillers: a literature review and proposed treatment algorithm. Clinical, Cosmetic and Investigational Dermatology, v. 13, p. 371–378, 2020. DOI: 10.2147/CCID.S247171.
TURKMANI, Mohammed G.; DE BOULLE, Koenraad; PHILIPP-DORMSTON, Wolfgang G. Delayed hypersensitivity reaction to hyaluronic acid dermal filler following influenza-like illness. Clinical, Cosmetic and Investigational Dermatology, v. 12, p. 277–283, 2019. DOI: 10.2147/CCID.S198081.
ROWLAND-WARMANN, M. J. Hypersensitivity reaction to hyaluronic acid dermal filler following novel coronavirus infection: a case report. Journal of Cosmetic Dermatology, v. 20, n. 5, p. 1557–1562, 2021. DOI: 10.1111/jocd.14074.
MICHON, Alain. Hyaluronic acid soft tissue filler delayed inflammatory reaction following COVID-19 vaccination: a case report. Journal of Cosmetic Dermatology, v. 20, n. 9, p. 2684–2690, 2021. DOI: 10.1111/jocd.14312.
SAVVA, Demetris et al. Hypersensitivity reaction to hyaluronic acid dermal filler after the Pfizer vaccination against SARS-CoV-2. International Journal of Infectious Diseases, v. 113, p. 233–235, 2021. DOI: 10.1016/j.ijid.2021.09.066.
DOS PASSOS LACERDA, Jamille, et al. "HARMONIZAÇÃO FACIAL COM ÁCIDO HIALURÔNICO EM PACIENTES CLASSE II TRATADOS COM ORTODONTIA COMPENSATORIA." Brazilian Journal of Implantology and Health Sciences 8.8 (2026): 787-801.
MUNAVALLI, Girish Gilly et al. Oral angiotensin-converting enzyme inhibitors for treatment of delayed inflammatory reaction to dermal hyaluronic acid fillers following COVID-19 vaccination: a model for inhibition of angiotensin II-induced cutaneous inflammation. JAAD Case Reports, v. 10, p. 63–68, 2021. DOI: 10.1016/j.jdcr.2021.02.018.
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2026 Pedro Henrique Alves, Régis Rodrigues Santana, Katiulcy Carvalho Oliveira, Ivan Silveira de Avelar, Luciene Apolinário de Araújo, Juliana Pires Ribeiro, Álvaro Paulo Silva Souza, Marcelo Carneiro dos Santos, Brenda Kaoanna Borges de Souza, Luiz Gustavo Nunes de Lima, Juliana Dias Medeiros, Camilla Cristina Almeida Silva
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Os autores são detentores dos direitos autorais mediante uma licença CCBY 4.0.
