Uso sistêmico de antidepressivos e falha de implantes dentários: uma revisão sistemática da evidência científica
DOI:
https://doi.org/10.36557/2674-8169.2026v8n7p801-822Keywords:
Implantes dentáriosAbstract
Aims: To evaluate whether the available scientific evidence supports an association between systemic antidepressant use and impaired osseointegration in dental implants.
Study Design: Systematic Review of the evidence
Place and Duration of Study: Brazilian Dental Association – Regional Santos, Santos, São Paulo, Brazil. Case 1: October 2009 to October 2023. Case 2: April 2015 to April 2024.
Methodology: A systematic review was conducted in accordance with PRISMA 2020 guidelines. Electronic searches were conducted in PubMed/MEDLINE, Scopus, Embase, Web of Science, Cochrane Library, and Google Scholar, without date restriction, including all records up to April 2026. Observational clinical studies evaluating the association between antidepressant use and implant failure were included. Risk of bias was assessed using the Newcastle–Ottawa Scale (NOS).
Results: Seven retrospective cohort studies were included. Most studies suggested a statistically significant association between antidepressant use and increased risk of dental implant failure; however, findings were not consistent across all studies. Selective serotonin reuptake inhibitors (SSRIs) were the most frequently investigated class, although results were heterogeneous. Some studies reported increased failure rates among SSRI users, while others found no significant association. Notably, one study observed a higher risk associated with serotonin–norepinephrine reuptake inhibitors (SNRIs) and tricyclic antidepressants (TCAs), rather than SSRIs. Overall methodological quality ranged from moderate to low risk of bias.
Conclusion: Current evidence suggests a possible association between antidepressant use and dental implant failure; however, the findings are inconsistent and do not support a clear or causal relationship. The effect may vary according to antidepressant class. Well-designed prospective studies are required to clarify the impact of antidepressants on osseointegration.
Keywords: Dental implants , Antidepressants, Selective serotonin reuptake inhibitors, Osseointegration, Implant failure
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Copyright (c) 2026 Alexandre de Lima Alves , Valter Castro Alves , Caio Vinícius G. Roman-Torres , Eduardo Guimarães Moreira Mangolin , Yeon Jung Kim
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