PDRN and Exosomes in Facial and Hair Regenerative Dermatology

Abstract

Regenerative dermatology has advanced significantly with the emergence of biologically based therapies aimed at restoring tissue function through cellular modulation. Among these, polydeoxyribonucleotide (PDRN) and exosomes have gained prominence due to their ability to act directly on molecular pathways involved in tissue repair and regeneration. This study aimed to review recent literature on the application of PDRN and exosomes in facial and hair regenerative dermatology, focusing on their mechanisms of action and clinical outcomes. An integrative literature review was conducted using major scientific databases, including PubMed, Scopus, Embase, and Web of Science, covering publications from 2020 to 2026. The findings demonstrate that both therapies promote fibroblast proliferation, stimulate collagen synthesis, enhance angiogenesis, and modulate inflammatory responses, contributing to improved skin quality and accelerated tissue repair. In the capillary context, these agents act on dermal papilla cells and follicular stem cells, activating pathways associated with the hair growth cycle, resulting in increased hair density, thickness, and reduced hair loss. Additionally, the combination of these therapies with transdermal delivery techniques, such as microneedling and laser, enhances their clinical effectiveness. Overall, PDRN and exosomes represent promising and synergistic approaches in regenerative dermatology, offering both structural and functional improvements in skin and hair conditions.