Doença Arterial Obstrutiva Periférica: Atualizações Diagnósticas e Terapêuticas Frente às Evidências e Diretrizes Internacionais
DOI:
https://doi.org/10.36557/2674-8169.2025v7n11p749-762Keywords:
Doença Arterial Obstrutiva Periférica, Aterosclerose, Diagnóstico Precoce, Terapia FarmacológicaAbstract
Peripheral Arterial Disease (PAD) represents one of the most prevalent and underdiagnosed manifestations of systemic atherosclerosis, strongly associated with adverse cardiovascular outcomes and progressive functional impairment. This integrative review aimed to synthesize and critically analyze recent evidence on the epidemiological profile, diagnostic strategies, and therapeutic approaches for PAD, emphasizing the implementation of international guidelines. Findings indicate a rising global prevalence, particularly among high-risk populations such as diabetics, smokers, and the elderly. Early diagnosis through ankle-brachial index and vascular imaging remains crucial but underutilized. Therapeutically, high-intensity statins, antiplatelet agents, and PCSK9 inhibitors have shown substantial clinical benefits. Moreover, machine learning–based predictive models are emerging as promising tools for personalized management, although broader clinical validation is still required. It is concluded that the comprehensive management of PAD demands multidisciplinary and individualized strategies focused on early intervention, therapeutic adherence, and evidence-based integration into local healthcare systems.
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Copyright (c) 2025 Armando Otávio Ponte Davi, Danielle Felix De Freitas Pessoa, Arthur Andrade Pimentel Fernandes, Guilherme Andrade Pimentel Fernandes, Edwin Bezerra Oliveira, Mateus Cavalcanti Siqueira, Lucas Cantarelli de Carvalho, Camila Teresa de Lima, Danillo Correia Santos Lira, Jônatas Cardoso da Silva Reis, Luana Ingrid Pinheiro Lima, Pedro José Targino Ribeiro, Martins Almeida de Morais Júnior
This work is licensed under a Creative Commons Attribution 4.0 International License.
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