PSORIASIS: A Bibliographic Review
DOI:
https://doi.org/10.36557/2674-8169.2025v7n9p1160-1172Keywords:
Psoriasis, Psoriasis pathophysiology, psoriasis treatment, Immunobiologics, Angiogenesis., Psoriasis, Psoriasis pathophysiology, psoriasis treatment, Immunobiologics, AngiogenesisAbstract
Objective: Investigate psoriasis, focusing on its pathophysiology, clinical forms, triggering factors, and therapeutic approaches. Methods: Narrative review on psoriasis, covering its pathophysiology, clinical forms, and treatment options. Literature Review: Psoriasis is a chronic inflammatory disease with genetic and environmental bases that affects the skin, presenting with varied clinical manifestations such as plaque, guttate, pustular psoriasis, and others. The interaction between immune cells and keratinocytes is central to the disease's development. Factors like stress, infections, and obesity act as triggers. Angiogenesis plays a significant role in psoriasis and is a promising therapeutic target. Treatment varies based on severity and includes topical corticosteroids, phototherapy, systemic medications, and immunobiologics. Conclusion: Psoriasis is a multifactorial, chronic disease with no cure, but it can be managed with effective therapies that improve patients' quality of life. However, its complex nature requires further studies and innovations in treatment.
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CASTILHO, A. C. da S.; LOPES, C. de O. P.; SALLES, B. C. C. Physiopathology of psoriasis and its immunological aspects: a systematic review. *Research, Society and Development*, [S. l.], v. 10, n. 11, p. e256101119346, 2021. DOI: 10.33448/rsd-v10i11.19346. Disponível em: https://rsdjournal.org/index.php/rsd/ article/view/19346.
GRIFFITHS, C. E. M.; ARMSTRONG, A. W.; GUDJONSSON, J. E.; BARKER, J. N. W. N. Psoriasis. *Lancet*, v. 397, n. 10281, p. 1301-1315, 3 abr. 2021. DOI: 10.1016/S0140-6736(20)32549-6. PMID: 33812489.
HEIDENREICH, R.; RÖCKEN, M.; GHORESCHI, K. Angiogenesis drives psoriasis pathogenesis. *International Journal of Experimental Pathology*, v. 90, n. 3, p. 232-248, jun. 2009. DOI: 10.1111/ j.1365-2613.2009.00669.x. Disponível em: https://doi.org/10.1111/j.1365-2613.2009.00669.x.
HORN, E. J. et al. Topical corticosteroids in psoriasis: strategies for improving safety. *Journal of the European Academy of Dermatology and Venereology*, v. 24, n. 2, p. 119-124, fev. 2010. DOI: 10.1111/ j.1468-3083.2009.03358.x. Disponível em: https://doi.org/10.1111/j.1468-3083.2009.03358.x.
JI, C.; WANG, H.; BAO, C.; ZHANG, L.; RUAN, S.; ZHANG, J.; GONG, T.; CHENG, B. Challenge of Nail Psoriasis: An Update Review. *Clinical Reviews in Allergy & Immunology*, v. 61, n. 3, p. 377-402, dez. 2021. DOI: 10.1007/s12016-021-08896-9. Epub 3 set. 2021. PMID: 34478047.
KORMAN, N. J. Management of psoriasis as a systemic disease: what is the evidence? *British Journal of Dermatology*, v. 182, n. 4, p. 840-848, abr. 2020. DOI: 10.1111/bjd.18245. Epub 15 out. 2019. PMID: 31225638; PMCID: PMC7187293.
LEE, H. J.; KIM, M. Desafios e tendências futuras no tratamento da psoríase. *International Journal of Molecular Sciences*, v. 24, n. 17, p. 13313, 28 ago. 2023. DOI: 10.3390/ijms241713313. Disponível em: <https://doi.org/10.3390/ijms241713313>.
MENTER, A. et al. Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics. *Journal of the American Academy of Dermatology*, v. 58, n. 5, p. 826-850, maio 2008. DOI: 10.1016/j.jaad.2008.02.039.
MORITA, A.; SAEKI, H. Pediatric psoriasis: Understanding pathological conditions and advances in treatment. *Journal of Dermatology*, v. 51, n. 2, p. 185-195, fev. 2024. DOI: 10.1111/1346-8138.17049. Epub 17 dez. 2023. PMID: 38105636; PMCID: PMC11483894.
ORSMOND, A.; BEREZA-MALCOLM, L.; LYNCH, T.; MARCH, L.; XUE, M. Skin barrier dysregulation in psoriasis. *International Journal of Molecular Sciences*, v. 22, n. 19, p. 10841, 7 out. 2021. DOI: 10.3390/ ijms221910841. PMID: 34639182; PMCID: PMC8509518.
PERRY, M. Psoriasis: an overview. *British Journal of Nursing*, v. 33, n. 15, p. 686-692, 13 ago. 2024. DOI: 10.12968/bjon.2024.0112. PMID: 39141331.
ROMITI, R.; HIRAYAMA, A. L. D. S.; ARNONE, M.; MAGALHÃES, R. F. Generalized pustular psoriasis (von Zumbusch). *Anais Brasileiros de Dermatologia*, v. 97, n. 1, p. 63-74, jan.-fev. 2022. DOI: 10.1016/ j.abd.2021.05.011. Epub 24 nov. 2021. PMID: 34838431; PMCID: PMC8799844.
RAHARJA, A.; MAHIL, S. K.; BARKER, J. N. Psoriasis: a brief overview. *Clinical Medicine (London)*, v. 21, n. 3, p. 170-173, mai. 2021. DOI: 10.7861/clinmed.2021-0257. PMID: 34001566; PMCID: PMC8140694.
SILVA, L. F. da; VEIGA, W. A. Psoríase: aspectos epidemiológicos e fisiopatológicos uma revisão de literatura. *Revista Ibero-Americana de Humanidades, Ciências e Educação*, v. 8, n. 9, p. 1241–1257, 2022. DOI: 10.51891/rease.v8i9.7055.
SILVA, João. Estudo sobre psoríase. 2020. Trabalho de conclusão de curso (Licenciatura em Ciências da Saúde) – Universidade Fernando Pessoa, Porto, 2020. Disponível em: <https://bdigital.ufp.pt/handle/ 10284/4486>.
SOBOLEV, V. et al. Differential Expression of Estrogen-Responsive Genes in Women with Psoriasis. *Journal of Personalized Medicine*, v. 11, p. 925, 2021. DOI: 10.3390/jpm11090925. Disponível em: https:// doi.org/10.3390/jpm11090925.
SUGUMARAN, D.; YONG, A. C. H.; STANSLAS, J. Advances in psoriasis research: From pathogenesis to therapeutics. *Life Sciences*, v. 355, p. 122991, 15 out. 2024. DOI: 10.1016/j.lfs.2024.122991. Epub 15 ago. 2024. PMID: 39153596.
TEIXEIRA, A. I.; LEAL FILIPE, P. Protocolos de fototerapia utilizados no tratamento da psoríase. *Revista da Sociedade Portuguesa de Dermatologia e Venereologia*, v. 74, n. 4, p. 355-362, 2016. DOI: 10.29021/spdv.74.4.674.
YOST, J.; GUDJONSSON, J. E. The role of TNF inhibitors in psoriasis therapy: new implications for associated comorbidities. *F1000 Medicine Reports*, v. 1, p. 30, 8 maio 2009. DOI: 10.3410/M1-30. PMID: 20948750; PMCID: PMC2924720.
XIAO, Y. et al. Age at natural menopause, reproductive lifespan, and the risk of late-onset psoriasis and psoriatic arthritis in women: A prospective cohort study. *Journal of Investigative Dermatology*, v. 144, n. 6, p. 1273-1281.e5, jun. 2024. DOI: 10.1016/j.jid.2023.11.010. Epub 10 dez. 2023. PMID: 38081449.
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Copyright (c) 2025 Gianna Antonelli Alves Zanchi, Matheus Henrique Santos Rodrigues, Jean Carlos Fernando Besson
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