Keywords
How to Cite
Abstract
Introduction: Epithelial carcinoma of the tongue is a malignant neoplasm that affects the oral mucosa and is more common in men over 50 years of age. This tumor can cause pain, speech and swallowing difficulties, and significantly affect the quality of life of patients. Early diagnosis and appropriate treatment are essential for a better prognosis. Objective: To report a case of epithelial carcinoma on the dorsum of the tongue, highlighting its clinical evolution, therapeutic approach and outcome, in addition to emphasizing the importance of early diagnosis and multidisciplinary follow-up in the management of the disease. Case Report: A 54-year-old female patient with a history of smoking and alcoholism for over 40 years presented with an ulcerated lesion on the dorsum of the tongue that had been growing progressively for six months, measuring approximately 2 centimeters. Clinical evaluation revealed an irregular, hardened mass that was painful to palpation. An incisional biopsy was performed, which confirmed the diagnostic hypothesis of squamous cell carcinoma. Imaging tests did not show distant metastases. Results: Given the diagnosis, the patient was referred to a head and neck surgeon to determine the best therapeutic strategy. Conclusion: Epithelial carcinoma on the dorsum of the tongue requires early diagnosis to ensure better clinical outcomes. Rapid identification of the disease allows the implementation of more effective therapeutic strategies, reducing complications and increasing patient survival. This case reinforces the importance of prevention, continuous follow-up, and a multidisciplinary approach in the treatment of this neoplasm.
References
ALMANGUSH, A. et al. Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis. British Journal of Cancer, v. 122, n. 6, p. 856-869, 2020.
BAGAN, J. et al. Câncer bucal: características clínicas. Oncologia Oral, v. 46, n. 6, p. 414-417, 2010.
CALIFANO, J. et al. Genetic progression model for head and neck cancer: implications for field cancerization. Cancer Research, v. 56, n. 11, p. 2488-2492, 1996.
CHATURVEDI, A. K. et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. Journal of Clinical Oncology, v. 31, n. 32, p. 4550-4559, 2013.
COHEN, E. E. W. et al. The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck. Journal for Immunotherapy of Cancer, v. 9, n. 3, e002052, 2021.
GANDINI, S. et al. Tabagismo e câncer: uma meta-análise. International Journal of Cancer, v. 122, n. 1, p. 155-164, 2008.
HECHT, SS Carcinogênese pulmonar pela fumaça do tabaco. International Journal of Cancer, v. 131, n. 12, p. 2724-2732, 2012.
JOHNSON, D. E. et al. Head and neck squamous cell carcinoma. Nature Reviews Disease Primers, v. 6, n. 1, p. 92, 2020.
KREIMER, A. R. et al. Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiology, Biomarkers & Prevention, v. 14, n. 2, p. 467-475, 2005.
KHURI, FR et al. O impacto do tabagismo, do estágio da doença e do sítio tumoral índice na incidência de segundo tumor primário e na recorrência tumoral no ensaio de quimioprevenção com retinoides em cabeça e pescoço. Epidemiologia do Câncer, Biomarcadores e Prevenção, v. 10, n. 8, p. 823-829, 2001.
KRUEGER, JK et al. Efeitos do tabagismo nas complicações pós-operatórias em reconstruções de cabeça e pescoço. Cirurgia Plástica e Reconstrutiva, v. 115, n. 6, p. 1577-1582, 2005.
LEEMANS, C. R. et al. The molecular landscape of head and neck cancer. Nature Reviews Cancer, v. 18, n. 5, p. 269-282, 2018.
LINGEN, MW et al. Avaliação crítica de meios auxiliares de diagnóstico para a detecção do câncer bucal. Oncologia Oral, v. 44, n. 1, p. 10-22, 2008.
MARUR, S. et al. Câncer de cabeça e pescoço associado ao HPV: uma epidemia de câncer relacionada ao vírus. The Lancet Oncology, v. 11, n. 8, p. 781-789, 2010.
MCLEOD, NMH et al. Câncer bucal: atrasos no encaminhamento e no diagnóstico. British Dental Journal, v. 198, n. 11, p. 681-684, 2005.
NATIONAL COMPREHENSIVE CANCER NETWORK. Head and Neck Cancers (Version 1.2024). Disponível em: https://www.nccn.org/professionals/physician_gls/pdf/head-and-neck.pdf. Acesso em: 15 maio 2024.
PENTENERO, M. et al. Importância da espessura tumoral e da profundidade de invasão no envolvimento ganglionar e prognóstico do carcinoma espinocelular oral: uma revisão da literatura. Head & Neck, v. 27, n. 12, p. 1080-1091, 2005.
PFISTER, D. G. et al. Head and neck cancers, version 2.2020: NCCN clinical practice guidelines in oncology. Journal of the National Comprehensive Cancer Network, v. 18, n. 7, p. 873-898, 2020.
REDE ATLAS DO GENOMA DO CÂNCER. Caracterização genômica abrangente de carcinomas espinocelulares de cabeça e pescoço. Nature, v. 517, n. 7536, p. 576-582, 2015.
RIVERA, C. et al. Oral and oropharyngeal cancer in young patients: a systematic review. Oral Diseases, v. 25, n. 8, p. 1914-1924, 2019.
SANKARANARAYANAN, R. et al. Efeito do rastreamento na mortalidade por câncer bucal em Kerala, Índia: um ensaio clínico randomizado por cluster. The Lancet, v. 365, n. 9475, p. 1927-1933, 2005.
STRANSKY, N. et al. O panorama mutacional do carcinoma espinocelular de cabeça e pescoço. Science, v. 333, n. 6046, p. 1157-1160, 2011.
SUNG, H. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, v. 71, n. 3, p. 209-249, 2021.
TORRES-PEREIRA, CC et al. Políticas públicas para o câncer bucal: existe realmente um compromisso? Anticancer Research, v. 30, n. 4, p. 1385-1389, 2010.
WARNAKULASURIYA, S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncology, v. 45, n. 4-5, p. 309-316, 2009.
WARNAKULASURIYA, S. Causes of oral cancer – an appraisal of controversies. British Dental Journal, v. 207, n. 10, p. 471-475, 2009.
WARNAKULASURIYA, S. Living with oral cancer: epidemiology with particular reference to prevalence and life-style changes that influence survival. Oral Oncology, v. 46, n. 6, p. 407-410, 2010.
WEINSTEIN, GS et al. Cirurgia robótica transoral: amigdalectomia radical. Arquivos de Otorrinolaringologia - Cirurgia de Cabeça e Pescoço, v. 133, n. 12, p. 1220-1226, 2007.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2025 Luis Eduardo Damasceno Silva, Kayo Pereira Lima , Diego Reinaldo de moura Souza , Allan Eric marques pereira , Thiago Henrique Gonçalves Moreira
