Keywords
Sheehan Syndrome
Pituitary Hormones
Hypothalamo-Hypophyseal System
How to Cite
Abstract
This study aimed to investigate the epidemiological, pathophysiological and therapeutic aspects of Sheehan Syndrome, an obstetric complication resulting from postpartum pituitary necrosis. For this purpose, articles published between 2019 and 2024, in English and Portuguese, in the PubMed and Google Scholar databases, were analyzed using specific terms related to the condition. This condition occurs due to anterior pituitary ischemia, triggered by severe obstetric hemorrhage and hypovolemic shock. The resulting pituitary failure can lead to variable clinical manifestations, including amenorrhea, hypoglycemia, hypotension and adrenal insufficiency. Diagnosis is often late, being based on clinical signs, hormone dosages and pituitary imaging exams. Management involves hormone replacement according to the affected axis, highlighting the need for glucocorticoid replacement to avoid potentially fatal adrenal crises. Early identification of risk factors and appropriate management of postpartum hemorrhage are essential to prevent Sheehan Syndrome and reduce maternal morbidity and mortality.
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This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2025 Thiago José Islanderson dos Santos Castro, Josiane Simplicio de Abreu , João Pedro Gomes Pequeno Gonzaga, Rômulo José Falcão Farias, Beatriz Bastos Santos , Maria Gabriela Lermen de Souza , Liz Silva Mariano , Victoria Herrera de Souza , Pedro Lucas Pessoa Cardoso , Gabriel Alves Da Silva Santiago , Ana Caroline dos Santos Sousa , Camila Camaia Souza Winter , Emanoele Batista Rafael , Caio Gabriel Ferreira Souza , Gabriela Castro de França, Brenna Martins Barboza
