Behçet's disease: a narrative review

Authors

  • Thiago José Islanderson dos Santos Castro UNINASSAU
  • Josiane Simplicio de Abreu UNINASSAU
  • João Pedro Gomes Pequeno Gonzaga UNINASSAU
  • Rômulo José Falcão Farias UNINASSAU
  • Brenda Lorenna de Jesus Araújo UniAtenas
  • Beatriz Bastos Santos UNINASSAU
  • Maria Gabriela Lermen de Souza UNINASSAU
  • Liz Silva Mariano UNINASSAU
  • Pedro Lucas Pessoa Cardoso UNINASSAU
  • Gabriel Alves Da Silva Santiago UNINASSAU
  • Ana Caroline dos Santos Sousa UNINASSAU
  • Camila Camaia Souza Winter UNINASSAU
  • Caio Gabriel Ferreira Souza UNINASSAU
  • Gabriela Castro de França UNINASSAU
  • Brenna Martins Barboza UNINASSAU
  • Emanoele Batista Rafael
  • Henrique Lima Martins
  • Monique Lima Martins

DOI:

https://doi.org/10.36557/2674-8169.2025v7n6p480-492

Keywords:

Behcet Syndrome, Vasculitis, Oral Ulcer, Erythema Nodosum, Autoimmunity

Abstract

This article aims to explore the pathophysiology, clinical manifestations, and therapeutic options of Behçet's Disease (BD) based on recent scientific publications. Studies published between 2019 and 2024, in English and Portuguese, were selected from the PubMed database, using terms related to the disease. BD is a chronic inflammatory vasculitis of autoimmune origin, which can affect vessels of different calibers and compromise multiple systems of the body. Its main manifestations include recurrent oral and genital ulcers, skin lesions, joint involvement, and gastrointestinal and neurological symptoms. Among the most serious complications, uveitis stands out, which can progress to irreversible visual loss. The diagnosis is essentially clinical and follows the criteria of the International Study Group for Behçet's Disease, based on the recurrence of manifestations. Although there is no cure, treatment aims to control inflammation and reduce the risk of complications, with immunosuppressants and anti-inflammatories being the main therapeutic approaches. Early diagnosis and ongoing medical monitoring are essential to improve the prognosis and quality of life of patients.

Downloads

Download data is not yet available.

References

AL-OBEIDI, A. F; NOWATZKY, J. IMMUNOPATHOGENESIS OF BEHÇET’S DISEASE. Clinical Immunology, v. 253, p. 1-19, 2023.

ANDRADE, M. M., et al. DOENÇA DE BEHÇET: AVALIAÇÃO REUMATOLÓGICA E COMPLICAÇÕES OFTALMOLÓGICAS. Revista Ibero-Americana de Humanidades, Ciências e Educação, v. 9, n. 9, p. 1-11, 2023.

BELCZAK, S. Q., et al. Tratamento endovascular da doença de Behçet: relato de caso. Jornal Vascular Brasileiro, v. 18, p. 1-5, 2019.

DUMONT, L. S., et al. Tratamento endovascular na doença de Behçet: uma revisão integrativa. Jornal Vascular Brasileiro, v. 21, p. 1-7, 2022.

HATEMI, G., et al. Behçet’s syndrome: one year in review 2023. Clinical and Experimental Rheumatology, v. 41, p. 1945-1954, 2023.

LAVELLE, S., et al. Behçet’s Disease, Pathogenesis, Clinical Features, and Treatment Approaches: A Comprehensive Review. Medicina, v. 60, n. 4, p. 1-16, 2024.

MAGALHÃES, A. C. F., et al. Doença de Behçet - uma revisão de literatura. Brazilian Journal of Health Review, v. 7, n. 4, p. 1-14, 2024.

PASCOLAT, G; MELLO, G. F; BOESE, L. C. R. DOENÇA DE BEHÇET EM ADOLESCENTE: RELATO DE CASO. Revista de Medicina, v. 78, n. 1, p. 97-100, 2020.

PEREIRA, S. L. A; ARAÚJO, D. B; CARVALHO, J. F. Manifestações neurológicas da doença de Behçet. Revista de Ciências Médicas e Biológicas, v. 19, n. 1, p. 144-146, 2019.

PIMENTEL, E. A., et al. DOENÇA DE BEHÇET VERSUS DOENÇA INFLAMATÓRIA INTESTINAL: SIMILARIDADES CLÍNICAS, MECANISMOS PATOGÊNICOS E IMPLICAÇÕES TERAPÊUTICAS. Brazilian Journal of Implantology and Health Sciences, v. 7, n. 1, p. 902-911, 2025.

SOUZA, D. R., et al. OS DESAFIOS ENCONTRADOS AO DIAGNÓSTICO DA DOENÇA DE BEHÇET: UMA REVISÃO DE LITERATURA. Revista Científica Interdisciplinar, v. 8, p. 165-178, 2023.

TIMM, A. R., et al. Aneurisma de artéria pulmonar por doença de Behçet: síndrome de Hughes Stovin. BioSCIENCE, v. 80, n. 2, p. 154-156, 2022.

TONG, B., et al. Immunopathogenesis of Behcet’s Disease. Frontiers in Immunology, v. 10, p. 1-12, 2019.

VARGAS, R. M., et al. Acometimento vascular na doença de Behçet: o processo imunopatológico. Jornal Vascular Brasileiro, v. 20, p. 1-7, 2021.

WATTS, R. A., et al. Global epidemiology of vasculitis. Nature Reviews Rheumatology, v. 18, p. 22-34, 2022.

Downloads

Published

2025-06-08

How to Cite

Castro, T. J. I. dos S., Abreu , J. S. de, Gonzaga, J. P. G. P., Farias, R. J. F., Araújo, B. L. de J., Santos , B. B., Souza , M. G. L. de, Mariano , L. S., Cardoso , P. L. P., Santiago , G. A. D. S., Sousa , A. C. dos S., Winter , C. C. S., Souza , C. G. F., França , G. C. de, Barboza , B. M., Rafael, E. B., Martins, H. L., & Martins, M. L. (2025). Behçet’s disease: a narrative review . Brazilian Journal of Implantology and Health Sciences, 7(6), 480–492. https://doi.org/10.36557/2674-8169.2025v7n6p480-492

Issue

Vol. 7 No. 6 (2025): BJIHS QUALIS B3 - FATOR DE IMPACTO SJIF 5.807 - ÍNDICE H 22

Section

Literature Review

License

Copyright (c) 2025 Thiago José Islanderson dos Santos Castro, Josiane Simplicio de Abreu , João Pedro Gomes Pequeno Gonzaga, Rômulo José Falcão Farias, Brenda Lorenna de Jesus Araújo, Beatriz Bastos Santos , Maria Gabriela Lermen de Souza , Liz Silva Mariano , Pedro Lucas Pessoa Cardoso , Gabriel Alves Da Silva Santiago , Ana Caroline dos Santos Sousa , Camila Camaia Souza Winter , Caio Gabriel Ferreira Souza , Gabriela Castro de França , Brenna Martins Barboza , Emanoele Batista Rafael, Henrique Lima Martins, Monique Lima Martins

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors are copyright holders under a CCBY 4.0 license.