Cutting-Edge Therapeutic Advances for Hematologic Cancers: Leukemia, Lymphoma, and Myeloma.

Authors

  • Victor Vilela Carvalho Severino graduado em medicina na universidade do Vale do sapucai em 2019 Clínica médica pelo hospital das clínicas samuel libanio 2020-2022
  • Gustavo Novelino Reis Graduando em medicina - Universidade Federal do Triângulo Mineiro - UFTM
  • Ana Paula Oliveira Silva graduando em medicina - IMEPAC ARAGUARI
  • Arthur Mendes Porto Passos graduado em medicina - centro universitário UniFacig
  • Ariany Parreira de Mendonça GRADUANDO EM MEDICINA - IMEPAC

DOI:

https://doi.org/10.36557/2674-8169.2023v5n5p99-111

Keywords:

Cânceres hematológicos, terapias-alvo, imunoterapia, avanços terapêuticos, terapia CAR-T

Abstract

This review article highlights cutting-edge therapeutic advancements in hematologic cancers such as leukemia, lymphoma, and myeloma, which are revolutionizing the landscape of treating these diseases. Targeted therapies, immunotherapies, and CAR-T therapy have emerged as fundamental pillars in combating hematologic cancer, offering remarkable outcomes like profound and enduring responses. The customization of treatment tailored to individual patient and disease characteristics has proven crucial in this context, though significant challenges persist, including therapeutic resistance and global accessibility. Nonetheless, the future of hematologic oncology holds promise, with ongoing research directed towards enhancing patients' quality of life and survival prospects, instilling hope and fostering continuous progress in the field of oncologic hematology. These therapeutic innovations signify a milestone in the battle against hematologic cancers, yielding previously unimaginable results. Targeted therapies aimed at specific mutations, immunotherapy bolstering the patient's immune system, and CAR-T therapy employing modified immune cells to target cancerous cells are demonstrating remarkable efficacy, offering hope for both patients and clinicians. Nevertheless, challenges remain, necessitating the management of therapeutic resistance that may arise over time and ensuring global access to these advanced therapies. As research continues to advance, the horizon of hematologic oncology promises ongoing enhancements in patients' quality of life and survival prospects, establishing a scenario where hematologic cancer can be effectively treated with renewed hope.

Downloads

Download data is not yet available.

References

AMADORI, S., et al. (2009). Gemtuzumab ozogamicin (Mylotarg) as a single agent for molecularly relapsed acute promyelocytic leukemia. Blood, 114(7), 1379-1384.

COIFFIER, B., et al. (2002). Rituximab (anti-CD20 monoclonal antibody) for the treatment of patients with relapsing or refractory aggressive lymphoma: a multicenter phase II study. Blood, 98(8), 2962-2968.

DRUKER, B. J., et al. (2001). Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. New England Journal of Medicine, 344(14), 1031-1037.

D'ANGELO, S. P., et al. (2020). Efficacy and safety of 177Lu-dotatate for midgut neuroendocrine tumors: the NETTER-1 trial. Journal of Clinical Oncology, 38(6), 557-565.

GILL, S., et al. (2019). CRISPR-Cas9 gene editing for cancer immunotherapy: bench to bedside. Immunotherapy, 11(10), 801-811.

KANTARJIAN, H., et al. (2006). Nilotinib in imatinib-resistant CML and Philadelphia chromosome–positive ALL. New England Journal of Medicine, 354(24), 2542-2551.

KANTARJIAN, H. M., et al. (2013). Ponatinib in refractory Philadelphia chromosome–positive leukemias. New England Journal of Medicine, 367(22), 2075-2088.

KANTARJIAN, H. M., et al. (2017). Blinatumomab versus chemotherapy for advanced acute lymphoblastic leukemia. New England Journal of Medicine, 376(9), 836-847.

MARCUS, R., et al. (2017). Obinutuzumab for the first-line treatment of follicular lymphoma. New England Journal of Medicine, 377(14), 1331-1344.

MAUDE, S. L., et al. (2014). Chimeric antigen receptor T cells for sustained remissions in leukemia. New England Journal of Medicine, 371(16), 1507-1517.

MOREAU, P., et al. (2016). Oral ixazomib, lenalidomide, and dexamethasone for multiple myeloma. New England Journal of Medicine, 374(17), 1621-1634.

MUNSHI, N. C., et al. (2021). Idecabtagene vicleucel in relapsed and refractory multiple myeloma. New England Journal of Medicine, 384(8), 705-716.

RICHARDSON, P. G., et al. (2003). Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. New England Journal of Medicine, 352(24), 2487-2498.

SEHN, L. H., et al. (2018). Polatuzumab vedotin in relapsed or refractory diffuse large B-cell lymphoma. Journal of Clinical Oncology, 36(9), 849-856.

SEHN, L. H., et al. (2019). Polatuzumab vedotin plus bendamustine with rituximab in relapsed/refractory diffuse large B-cell lymphoma: updated results of a phase Ib/II randomized study. Blood, 134(Supplement_1), 764-764.

Published

2023-10-02

How to Cite

Severino , V. V. C., Reis , G. N., Silva , A. P. O., Passos , A. M. P., & Mendonça , A. P. de. (2023). Cutting-Edge Therapeutic Advances for Hematologic Cancers: Leukemia, Lymphoma, and Myeloma. Brazilian Journal of Implantology and Health Sciences, 5(5), 99–111. https://doi.org/10.36557/2674-8169.2023v5n5p99-111

Issue

Section

Literature Review