EFFECTIVENESS OF NANOPARTICLES IN DECONTAMINATION OF ROOT CANALS AND PRESERVATION OF MECHANICAL PROPERTIES OF THE REMNANT
DOI:
https://doi.org/10.36557/2674-8169.2025v7n2p2575-2590Keywords:
Nanoparticles, Nanotechnology, Root Canal IrrigantsAbstract
Objectives: To evaluate the effectiveness of nanoparticles in decontaminating and maintaining the mechanical properties of the remaining teeth. Methodology: This is a literature review that was carried out between January 2025 and February 2025, the question that guided the search was “Does the use of nanoparticles increase the effectiveness of decontaminating root canals and preserving the mechanical properties of the remainder?”. From this, a search was carried out in the PubMed (U.S. National Library of Medicine) and VHL (Virtual Health Library) databases, with a time span of 5 years. The search strategy was formulated by combining the descriptors indexed in DeCS/MeSH “Nanoparticles”, “Nanotechnology” and “Root Canal Irrigants”, combined with the Boolean operator “AND”. The selection criteria were: studies published in the last 5 years, which were related to the guiding question, with full text available in Portuguese, English and Spanish, systematic literature reviews, meta-analyses and randomized clinical trials. The initial search resulted in the identification of 11 articles. Of these, 6 articles were included in the search. Conclusion: Nanoparticles showed potential in endodontics, with antimicrobial action and preservation of dentin. Those with silver and zinc oxide combatted multispecies biofilms, while those with calcium hydroxide improved drug release. More clinical studies are needed to validate its efficacy and safety.
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References
DE ALMEIDA, J. et al. Effectiveness of nanoparticles solutions and conventional endodontic irrigants against Enterococcus faecalis biofilm. Indian Journal of Dental Research, v. 29, n. 3, p. 347-351, 2018.
DIOGO, P. et al. Is the chlorophyll derivative Zn (II) e6Me a good photosensitizer to be used in root canal disinfection?. Photodiagnosis and Photodynamic Therapy, v. 22, p. 205-211, 2018.
DIOGO, P. et al. An insight into advanced approaches for photosensitizer optimization in endodontics—A critical review. Journal of functional biomaterials, v. 10, n. 4, p. 44, 2019.
ELMSMARI, F. et al. Calcium hydroxide‐loaded PLGA biodegradable nanoparticles as an intracanal medicament. International Endodontic Journal, v. 54, n. 11, p. 2086-2098, 2021.
ELMSMARI, F. et al. Development of clobetasol‐loaded biodegradable nanoparticles as an endodontic intracanal medicament. International endodontic journal, 2024.
ESTRELA, C. et al. Two methods to evaluate the antimicrobial action of calcium hydroxide paste. Journal of Endodontics, v. 27, n. 12, p. 720-723, 2001.
FARGES, J. et al. Dental pulp defence and repair mechanisms in dental caries. Mediators of inflammation, v. 2015, n. 1, p. 230251, 2015.
FRANCI, G. et al. Silver nanoparticles as potential antibacterial agents. Molecules, v. 20, n. 5, p. 8856-8874, 2015.
JOWKAR, Z. et al. The effect of silver, zinc oxide, and titanium dioxide nanoparticles used as final irrigation solutions on the fracture resistance of root-filled teeth. Clinical, cosmetic and investigational dentistry, p. 141-148, 2020.
LEELAPORNPISID, W.; WANWATANAKUL, P.; MAHATNIRUNKUL, T. Efficacy of calcium hydroxide‐loaded poly (lactic‐co‐glycolic acid) biodegradable nanoparticles as an intracanal medicament against endodontopathogenic microorganisms in a multi‐species biofilm model. Australian Endodontic Journal, v. 50, n. 1, p. 89-96, 2024.
LOVE, R. M.; JENKINSON, H. F. Invasion of dentinal tubules by oral bacteria. Critical reviews in oral biology & medicine, v. 13, n. 2, p. 171-183, 2002.
MARÍN-CORREA, B. M. et al. Nanosilver gel as an endodontic alternative against Enterococcus faecalis in an in vitro root canal system in Mexican dental specimens. New Microbiol, v. 43, n. 4, p. 166-70, 2020.
MCHUGH, C. P. et al. pH required to kill Enterococcus faecalis in vitro. Journal of endodontics, v. 30, n. 4, p. 218-219, 2004.
PANÁČEK, A. et al. Bacterial resistance to silver nanoparticles and how to overcome it. Nature nanotechnology, v. 13, n. 1, p. 65-71, 2018.
RODRIGUES, C. T. et al. Antibacterial properties of silver nanoparticles as a root canal irrigant against Enterococcus faecalis biofilm and infected dentinal tubules. International Endodontic Journal, v. 51, n. 8, p. 901-911, 2018.
ROIG, X. et al. Calcium hydroxide‐loaded nanoparticles dispersed in thermosensitive gel as a novel intracanal medicament. International endodontic journal, 2024.
SAHEBI, S. et al. The effect of nanobased irrigants on the root canal dentin microhardness: an ex-vivo study. BMC Oral Health, v. 23, n. 1, p. 581, 2023.
SAMIEI, M. et al. Antibacterial efficacy of polymer containing nanoparticles in comparison with sodium hypochlorite in infected root canals. Minerva stomatologica, v. 64, n. 6, p. 275-281, 2015.
SIREESHA, A. et al. Comparative evaluation of micron-and nano-sized intracanal medicaments on penetration and fracture resistance of root dentin–An in vitro study. International journal of biological macromolecules, v. 104, p. 1866-1873, 2017.
SHAKYA, A. K. et al. Review on PLGA polymer based nanoparticles with antimicrobial properties and their application in various medical conditions or infections. Polymers, v. 15, n. 17, p. 3597, 2023.
WILSON, C. E. et al. Clonal diversity in biofilm formation by Enterococcus faecalis in response to environmental stress associated with endodontic irrigants and medicaments. International endodontic journal, v. 48, n. 3, p. 210-219, 2015.
WONG, J. et al. The potential translational applications of nanoparticles in endodontics. International Journal of Nanomedicine, p. 2087-2106, 2021.
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Copyright (c) 2025 Maria Eduarda Darigo Vasconcelos, Amanda Alves da Nóbrega, Ana Karinne da Silva Ferreira, Anderson Daniel Vicente da Silva, Antônio Marcos Barboza de Oliveira, Camila Faro Carmo, Edson Antônio da Silva, Gabriel Levino Araújo de Macedo, Graziella Valda Oliveira Sousa Bôa Morte, Joana Alice dos Santos Luciano, Maria Beatriz Galindo Costa, Maria Eduarda da Silva Souza, Mayara Paula Morais da Paz, Naama Júlia Mota Ferreira, Nathalia Suelle dos Reis Mendonça, Olivia Maria Araújo Clemente, Raylana Vitória da Silva Vasconcelos, Suzana Maria Santos de Araújo Souza
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