Advances in Cell Therapies for the Treatment of Relapsing-Remitting Multiple Sclerosis: Therapeutic Potential of Dental Pulp-Derived Stem Cells.
DOI:
https://doi.org/10.36557/2674-8169.2025v7n2p2470-2484Keywords:
Célula Tronco, Células Mesenquimais, Polpa dentária, Esclerose MúltiplaAbstract
Multiple Sclerosis (MS) is a chronic central nervous system disease that affects the spinal cord, brain, and optic nervethrough the demyelination of nerve fibers. The relapsing-remitting form (RRMS) is the most common, characterized by sudden neurological relapses that may last for days or weeks, followed by periods of partial or complete remission of symptoms. In recent years, mesenchymal stem cell (MSC) therapies have been widely studied due to their regenerative and immunomodulatory potential in the treatment of RRMS. In particular, mesenchymal stem cells derived from the pulp of deciduous teeth (SHED) have shown promising results, as they exhibit high plasticity and differentiation capacity. This study is a literature review aimed at analyzing the available scientific evidence on the use of mesenchymal stem cells from deciduous dental pulp in the treatment of relapsing-remitting multiple sclerosis. Additionally, it sought to identify the potential short- and long-term benefits of this therapy, as well as its impact on patients' quality of life. A total of 26 articles were analyzed, selected through searches in the Virtual Health Library (VHL), Google Scholar, PubMed, SciELO, and EbscoHost databases. The results highlighted multiple benefits of cell therapy, including improved quality of life, immunomodulatory effects, and myelin regeneration, especially in patients with RRMS. The literature suggests that this approach could represent an innovative and effective strategy for managing RRMS, opening new therapeutic perspectives for this neurodegenerative condition.
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