Lesão hepática induzida por ervas: revisão sistemática

Authors

  • Giovanna Uchôa de Souza Cruz UNIVERSIDADE FEDERAL DO TOCANTINS
  • Jan Carlos Leão Alves Universidade Federal de Rondônia
  • Lucas Moura Araujo Luz Uninovafapi https://orcid.org/0009-0000-1582-7375
  • Marcus Vinícius de Magalhães Oliveira Centro Universitário Tocantinense Presidente Antônio Carlos- Unitpac
  • Raphael Alves Gomes Braga UNIGRANRIO
  • Isabella Fróes Demétrio UNIG - Universidade Iguaçu campus V
  • Igor Barreto de Faria UNIATENAS - Paracatu
  • Daniella Oliveira Faria Eulálio Faculdade de Medicina de Olinda
  • Vinicius Lima de Medeiros Centro Universitário Uninovafapi
  • Mariana Rodrigues Bezerra Universidade Federal do Rio de Janeiro
  • Andresa Maria Eccard André Universidade Iguaçu - Campus V
  • Bernardo Humberto Michiles Vianez Centro Universitário Fametro
  • Eliane Teixeira dos Santos Universidade Federal do Recôncavo da Bahia- UFRB
  • Eloisa Possimoser Negri UNINASSAU VILHENA/RO
  • Vitor Cavalli UNINASSAU VILHENA/RO
  • Anne Caroline Tavares de Carvalho Hospital Militar de Área de Brasília - HMAB
  • Thalia Diniz da Silva Faculdade de ciências médicas Afya Santa Inês

DOI:

https://doi.org/10.36557/2674-8169.2025v7n2p1078-1090

Keywords:

Liver Injury; HILI; Herbs; Hepatotoxicity.

Abstract

Drug-induced liver injury (DILI) is the term used to describe liver test abnormalities and liver dysfunction caused by various medications. In recent decades, the use of herbal supplements, natural products and alternative medicines has increased considerably, which is consistently underreported by patients. Despite the popular belief that the consumption of natural products is harmless, herbs can cause damage to various organs. This is especially true for the liver, which is responsible for your metabolism. Even in the absence of data proving safety or efficacy, the market for herbal and alternative medicines has expanded greatly, reaching as much as US$83.1 billion in 2012. Herbal-induced liver injury (HILI) is a term currently used to describe herbal medicine-related liver injuries, which both doctors and patients should be aware of.

Downloads

Download data is not yet available.

Author Biographies

Giovanna Uchôa de Souza Cruz, UNIVERSIDADE FEDERAL DO TOCANTINS

Graduada em Medicina. 

Residente em Clínica Médica pela Universidade Federal do Tocantins

Jan Carlos Leão Alves, Universidade Federal de Rondônia

Graduado em Medicina 

Lucas Moura Araujo Luz, Uninovafapi

Graduado em Medicina 

Marcus Vinícius de Magalhães Oliveira, Centro Universitário Tocantinense Presidente Antônio Carlos- Unitpac

Graduado em Medicina 

Raphael Alves Gomes Braga, UNIGRANRIO

Graduado em Medicina 

Isabella Fróes Demétrio, UNIG - Universidade Iguaçu campus V

 Acadêmica de Medicina

Igor Barreto de Faria, UNIATENAS - Paracatu

Acadêmico de Medicina

Daniella Oliveira Faria Eulálio, Faculdade de Medicina de Olinda

Acadêmico de Medicina

Vinicius Lima de Medeiros, Centro Universitário Uninovafapi

Acadêmico de Medicina 

Mariana Rodrigues Bezerra, Universidade Federal do Rio de Janeiro

Graduada em Medicina 

Andresa Maria Eccard André, Universidade Iguaçu - Campus V

Acadêmica de Medicina 

Bernardo Humberto Michiles Vianez, Centro Universitário Fametro

Acadêmico de Medicina

Eliane Teixeira dos Santos, Universidade Federal do Recôncavo da Bahia- UFRB

Graduada em Medicina 

Eloisa Possimoser Negri, UNINASSAU VILHENA/RO

Graduada em Medicina 

Vitor Cavalli, UNINASSAU VILHENA/RO

Graduada em Medicina 

Anne Caroline Tavares de Carvalho, Hospital Militar de Área de Brasília - HMAB

Graduada em Medicina 

References

Suk KT, Kim DJ. Drug-induced liver injury: present and future. Clin Mol Hepatol. 2012;18:249–257. doi: 10.3350/cmh.2012.18.3.249. [DOI] [PMC free article] [PubMed] [Google Scholar]

Amadi CN, Orisakwe OE. Herb-Induced Liver Injuries in Developing Nations: An Update. Toxics. 2018;6 doi: 10.3390/toxics6020024. [DOI] [PMC free article] [PubMed] [Google Scholar]

LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet] 2012 . [Google Scholar]

Rashrash M, Schommer JC, Brown LM. Prevalence and Predictors of Herbal Medicine Use Among Adults in the United States. J Patient Exp. 2017;4:108–113. doi: 10.1177/2374373517706612. [DOI] [PMC free article] [PubMed] [Google Scholar]

Gyasi RM. Unmasking the Practices of Nurses and Intercultural Health in Sub-Saharan Africa: A Useful Way to Improve Health Care? J Evid Based Integr Med. 2018;23:2515690X18791124. doi: 10.1177/2515690X18791124. [DOI] [PMC free article] [PubMed] [Google Scholar]

Byeon JH, Kil JH, Ahn YC, Son CG. Systematic review of published data on herb induced liver injury. J Ethnopharmacol. 2019;233:190–196. doi: 10.1016/j.jep.2019.01.006. [DOI] [PubMed] [Google Scholar]

Zheng EX, Navarro VJ. Liver Injury from Herbal, Dietary, and Weight Loss Supplements: a Review. J Clin Transl Hepatol. 2015;3:93–98. doi: 10.14218/JCTH.2015.00006. [DOI] [PMC free article] [PubMed] [Google Scholar]

Bartnik C, Subramanian R. Kava Kava, Not for the Anxious: A Case of Fulminant Hepatic Failure After Kava Kava Supplementation: 2373. Offic J Am Coll Gastroenterol . 2017;112:S1292. [Google Scholar]

Yellapu RK, Mittal V, Grewal P, Fiel M, Schiano T. Acute liver failure caused by 'fat burners' and dietary supplements: a case report and literature review. Can J Gastroenterol. 2011;25:157–160. doi:

1155/2011/174978. [DOI] [PMC free article] [PubMed] [Google Scholar] 10.Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA PRISMA-P Group. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4:1. doi: 10.1186/2046-4053-4-1. [DOI] [PMC free article] [PubMed] [Google Scholar]

Maria and Victorino (M & V) System of Causality Assessment in Drug Induced Liver Injury 2012. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012– . [PubMed] [Google Scholar]

Grieco A, Miele L, Pompili M, Biolato M, Vecchio FM, Grattagliano I, Gasbarrini G. Acute hepatitis caused by a natural lipid-lowering product: when "alternative" medicine is no "alternative" at all. J Hepatol. 2009;50:1273–1277. doi: 10.1016/j.jhep.2009.02.021. [DOI] [PubMed] [Google Scholar]

Piccolo P, Gentile S, Alegiani F, Angelico M. Severe drug induced acute hepatitis associated with use of St John's wort (Hypericum perforatum) during treatment with pegylated interferon α. BMJ Case Rep. 2009;2009 doi: 10.1136/bcr.08.2008.0761. [DOI] [PMC free article] [PubMed] [Google Scholar]

Chow HC, So TH, Choi HCW, Lam KO. Literature Review of Traditional Chinese Medicine Herbs-Induced Liver Injury From an Oncological Perspective With RUCAM. Integr Cancer Ther. 2019;18:1534735419869479. [Google Scholar]

Ashar BH, Rice TN, Sisson SD. Medical residents' knowledge of dietary supplements. South Med J. 2008;101:996–1000. doi: 10.1097/SMJ.0b013e31817cf79e. [DOI] [PubMed] [Google Scholar]

Published

2025-02-08

How to Cite

Cruz, G. U. de S., Jan Carlos Leão Alves, Lucas Moura Araujo Luz, Marcus Vinícius de Magalhães Oliveira, Raphael Alves Gomes Braga, Isabella Fróes Demétrio, Igor Barreto de Faria, Daniella Oliveira Faria Eulálio, Vinicius Lima de Medeiros, Mariana Rodrigues Bezerra, Andresa Maria Eccard André, Bernardo Humberto Michiles Vianez, Eliane Teixeira dos Santos, Eloisa Possimoser Negri, Vitor Cavalli, Anne Caroline Tavares de Carvalho, & Thalia Diniz da Silva. (2025). Lesão hepática induzida por ervas: revisão sistemática. Brazilian Journal of Implantology and Health Sciences, 7(2), 1078–1090. https://doi.org/10.36557/2674-8169.2025v7n2p1078-1090