An integrative review on the characteristics of reactive arthritis related to the Covid-19 vaccine
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https://doi.org/10.36557/2674-8169.2025v7n1p1967-1977Keywords:
COVID-19 Vaccines, Arthritis, Reactive, Signs and Symptoms, TherapeuticsAbstract
Introduction: The emergence of vaccines was essential to contain the Covid-19 pandemic, however, side effects arose with them, including reactive arthritis. Objective: To detail the characteristics of ReA associated with vaccination against Covid-19. Methodology: This is an integrative review, with data from PubMed, using the descriptors COVID-19 Vaccines AND Arthritis, Reactive, without language and period restrictions. Discussion: Post-vaccination reactive arthritis against SARS-CoV-2 can appear after the use of any type of vaccine. It is not associated with HLA-B27. It was present in the age group from 17 to 90 years old, in most cases the symptoms started between 2 and 21 days after the first dose of the vaccine. The most affected joints are the ankle, knee, and hand joints. Treatment includes the administration of corticosteroids and/or NSAIDs orally or parenterally. Conclusion: The relationship between the vaccine and reactive arthritis is undeniable, and scientific productions that address this relationship are necessary. It is of great importance that healthcare professionals are aware of and able to guide and treat reactive arthritis related to the Covid-19 vaccine.
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Roseti L, Grigolo B. COVID-19 and rheumatic diseases: a mini-review. Front Med [Internet]. 26 set 2022 [citado 18 jan 2025];9. Disponível em: https://doi.org/10.3389/fmed.2022.997876
Golstein MA, Fagnart O, Steinfeld SD. Reactive arthritis after COVID19 vaccination: 17 cases. Rheumatology [Internet]. 21 abr 2023 [citado 18 jan 2025]. Disponível em: https://doi.org/10.1093/rheumatology/kead169
An QJ, Qin DA, Pei JX. Reactive arthritis after COVID-19 vaccination. Hum Vaccines Amp Immunother [Internet]. 25 maio 2021 [citado 18 jan 2025];17(9):2954-6. Disponível em: https://doi.org/10.1080/21645515.2021.1920274
Liu J, Wu H, Xia SL. New-Onset arthritis following COVID-19 vaccination: a systematic review of case reports. Vaccines [Internet]. 15 mar 2023 [citado 18 jan 2025];11(3):665. Disponível em: https://doi.org/10.3390/vaccines11030665
Bekaryssova D, Yessirkepov M, Zimba O, Gasparyan AY, Ahmed S. Reactive arthritis before and after the onset of the COVID-19 pandemic. Clin Rheumatol [Internet]. 5 mar 2022 [citado 18 jan 2025]. Disponível em: https://doi.org/10.1007/s10067-022-06120-3
Homepage | BMJ Best Practice [Internet]. Artrite reativa - Sintomas, diagnóstico e tratamento | BMJ Best Practice; [citado 18 jan 2025]. Disponível em: https://bestpractice.bmj.com/topics/pt-br/597
Wojturska W, Nowakowski J, Pilch W, Biernikowicz M, Korkosz M. Reactive arthritis after vaccination against SARS-CoV-2: a case series and a mini-review. Hum Vaccines Amp Immunother [Internet]. 6 fev 2023 [citado 18 jan 2025]. Disponível em: https://doi.org/10.1080/21645515.2023.2173912
Unal Enginar A. Arthritis following COVID-19 vaccination: report of two cases. Int Immunopharmacol [Internet]. Dez 2021 [citado 18 jan 2025];101:108256. Disponível em: https://doi.org/10.1016/j.intimp.2021.108256
Koh S, Chen H, Hsu C. Prolonged peripheral seronegative spondyloarthritis following BioNTech coronavirus disease 2019 vaccination: a case report. Int J Rheum Dis [Internet]. 8 dez 2022 [citado 18 jan 2025]. Disponível em: https://doi.org/10.1111/1756-185x.14512
Vanaskova E, Kelbich P, Novotny T. Reactive synovitis of the knee joint after COVID ‐19 vaccination: the first ultrastructural analysis of synovial fluid. Int J Rheum Dis [Internet]. 5 ago 2022 [citado 18 jan 2025]. Disponível em: https://doi.org/10.1111/1756-185x.14411
Roux N, Poussing S, Maurier F. Case of reactive sacroiliitis possibly induced by an mRNA coronavirus disease vaccine. BMJ Case Rep [Internet]. Jul 2022 [citado 18 jan 2025];15(7):e249063. Disponível em: https://doi.org/10.1136/bcr-2022-249063
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Copyright (c) 2025 Gabriela de Deus Miranda, Wemili de Andrade Langa, João Guilherme Rodrigues Cardoso , Leticia Peres de Lima, Cliciany Ferreira Sampaio Lima, Juliana Moreira de Melo, Matheus Alves de Sousa, Mateus Borges Almeida, Larissa Carvalho de Souza, Isadora Furlaneto Freire
This work is licensed under a Creative Commons Attribution 4.0 International License.
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