Regenerative Orthopedics: The Role of Biological Therapies in Joint Reconstruction
DOI:
https://doi.org/10.36557/2674-8169.2025v7n1p745-754Keywords:
Biological therapies; Joint regeneration; Platelet-rich plasma; Mesenchymal stem cells; Hyaluronic acid.Abstract
This study explores the impact of biological therapies on joint regeneration, focusing on their clinical applications, efficacy and limitations. The research adopts a narrative bibliographic review, analyzing articles published between 2014 and 2024 in renowned scientific databases. Biological therapies, such as platelet-rich plasma, mesenchymal stem cells, and hyaluronic acid, have demonstrated potential in restoring joint tissues and relieving symptoms in conditions such as osteoarthritis and joint injuries. The findings indicate significant advances, but also highlight challenges, such as the standardization of protocols and the variability of results between studies. It is concluded that, although promising, biological therapies still require additional studies to consolidate their effectiveness and expand clinical use.
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D’SOUZA, Ryan S. et al. Evidence-based clinical practice guidelines on regenerative medicine treatment for chronic pain: a consensus report from a multispecialty working group. Journal of pain research, p. 2951-3001, 2024.
JESUS, Larissa Santana de et al. Plasma rico em plaquetas para o tratamento da dor neuropática: uma revisão sistemática. 2024.
JHAN, Shun-Wun et al. A comparative analysis of platelet-rich plasma alone versus combined with extracorporeal shockwave therapy in athletes with patellar tendinopathy and knee pain: a randomized controlled trial. Knee Surgery & Related Research, v. 36, n. 1, p. 1-11, 2024.
LING, Samuel Ka-Kin et al. Effect of Platelet-Rich Plasma Injection on the Treatment of Achilles Tendinopathy: A Systematic Review and Meta-analysis. Orthopaedic Journal of Sports Medicine, v. 12, n. 11, p. 23259671241296508, 2024.
MATAS, Jose et al. A phase I dose-escalation clinical trial to assess the safety and efficacy of umbilical cord-derived mesenchymal stromal cells in knee osteoarthritis. Stem Cells Translational Medicine, v. 13, n. 3, p. 193-203, 2024.
PIRES, Diego Pontes de Carvalho et al. Atualizações no tratamento da osteoartrite de joelho. Revista Brasileira de Ortopedia, v. 59, p. 337-348, 2024.
RANA, Md Mohosin; DE LA HOZ SIEGLER, Hector. Evolution of Hybrid Hydrogels: Next-Generation Biomaterials for Drug Delivery and Tissue Engineering. Gels, v. 10, n. 4, p. 216, 2024.
XU, Yang et al. Platelet-rich plasma has better results for long-term functional improvement and pain relief for lateral epicondylitis: a systematic review and meta-analysis of randomized controlled trials. The American Journal of Sports Medicine, p. 03635465231213087, 2024.
WU, Kun-Chi et al. Mesenchymal Stromal Cells for Aging Cartilage Regeneration: A Review. International Journal of Molecular Sciences, v. 25, n. 23, p. 12911, 2024.
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Copyright (c) 2025 Guilherme Paes Espindola de Souza, Danilo Costa Shockness , Henrique Gregório Nolasco , Gabriel Lucena Cangussu, Henrique Morgado e Souza, Ariane Abreu Tsutsumi
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors are copyright holders under a CCBY 4.0 license.
