Impact of Nutrition on the Management of Inflammatory Bowel Diseases

Authors

  • Isadora Martins Gomes Fredrich Universidade Anhanguera-UNIDERP
  • Larah Luyza Canale Medeiros Universidade Anhanguera-UNIDERP
  • Mariana Maran Meira Universidade Anhanguera-UNIDERP
  • Thaís Helena Kirchesch e Costa Centro Universitário Integrado
  • Diego Salles Granzinoli Universidade Estácio de Sá – UNESA
  • Ana Hisi Fujii Ramos Universidade Anhanguera-UNIDERP
  • Camila Barbosa Wahl Witzler Universidade Anhanguera-UNIDERP
  • Isabele Souza Arinos Universidade Anhanguera-UNIDERP
  • Caroline Foletto Universidade Nove de Julho
  • Jonas Farias Sene Lopes Universidade Federal de Rondônia
  • Maria Clara Conciani de Oliveira Universidade Anhanguera-UNIDERP
  • Giovana Corrêa Bueno Universidade Anhanguera-UNIDERP
  • Marcelo Fontes da Silva Universidade Anhanguera-UNIDERP
  • José Amarildo Avanci Júnior Universidade Federal de Mato Grosso do Sul

DOI:

https://doi.org/10.36557/2674-8169.2025v7n1p1406-1420

Keywords:

Doenças Autoimunes, Fatores Dietéticos,, Imunomodulação, Terapia Nutricional

Abstract

Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis, are chronic conditions characterized by persistent inflammation of the gastrointestinal tract, significantly impacting patients' quality of life. This study aimed to critically review the literature on the role of nutrition in managing IBDs, exploring specific dietary interventions, immunomodulatory nutrients, and personalized nutritional strategies. The methodology consisted of an integrative literature review, encompassing articles published between 2013 and 2023, retrieved from databases such as PubMed, Scopus, Web of Science, and LILACS. Included studies investigated the impact of specific diets, such as exclusive enteral nutrition and the low-FODMAP diet, as well as nutrient supplementation, including omega-3, vitamin D, and bioactive compounds. The results indicated that nutritional interventions can modulate inflammation and the intestinal microbiome, promoting clinical remission and improving clinical outcomes. However, adherence to diets, the high cost of certain interventions, and the lack of standardized clinical guidelines remain significant challenges. Personalizing nutritional strategies, combined with integrating nutritionists into multidisciplinary teams, proved essential to overcoming these barriers. Robust clinical trials and long-term studies are needed to validate the efficacy of nutritional interventions and guide clinical practice. In conclusion, nutrition represents a promising and complementary tool in managing IBDs, with the potential to reduce inflammation, optimize nutritional status, and improve patients' quality of life.

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References

ADAMS SH, ANTHONY JC, CARVAJAL R, CHAE L, KHOO CSH, LATULIPPE ME, MATUSHESKI NV, MCCLUNG HL, ROZGA M, SCHMID CH, WOPEREIS S, YAN W. Perspective: Guiding Principles for the Implementation of Personalized Nutrition Approaches That Benefit Health and Function. Adv Nutr. 2020 Jan 1;11(1):25-34. doi: 10.1093/advances/nmz086. PMID: 31504115; PMCID: PMC7442375.

ASSA A, SHAMIR R. Exclusive enteral nutrition for inducing remission in inflammatory bowel disease in paediatric patients. Curr Opin Clin Nutr Metab Care. 2017 Sep;20(5):384-389. doi: 10.1097/MCO.0000000000000402. PMID: 28768295.

BARKHORDARI S, MIRMOSAYYEB O, MANSOURIAN M, HOSSEININASAB F, RAMEZANI S, BARZEGAR M, AMIN MM, POURSAFA P, ESMAEIL N, KELISHADI R. Omega 3 Supplementation Can Regulate Inflammatory States in Gas Station Workers: A Double-Blind Placebo-Controlled Clinical Trial. J Interferon Cytokine Res. 2020 May;40(5):262-267. doi: 10.1089/jir.2019.0220. Epub 2020 Mar 13. PMID: 32176565.

BARREA L, BOSCHETTI M, GANGITANO E, GUGLIELMI V, VERDE L, MUSCOGIURI G. Long-Term Efficacy and Safety of Nutritional and Pharmacological Strategies for Obesity. Curr Obes Rep. 2025 Jan 3;14(1):1. doi: 10.1007/s13679-024-00602-y. PMID: 39753703.

BISCHOFF SC, BAGER P, ESCHER J, FORBES A, HÉBUTERNE X, HVAS CL, JOLY F, KLEK S, KRZNARIC Z, OCKENGA J, SCHNEIDER S, SHAMIR R, STARDELOVA K, BENDER DV, WIERDSMA N, WEIMANN A. ESPEN guideline on Clinical Nutrition in inflammatory bowel disease. Clin Nutr. 2023 Mar;42(3):352-379. doi: 10.1016/j.clnu.2022.12.004. Epub 2023 Jan 13. PMID: 36739756.

CAI Z, WANG S, LI J. Treatment of Inflammatory Bowel Disease: A Comprehensive Review. Front Med (Lausanne). 2021 Dec 20;8:765474. doi: 10.3389/fmed.2021.765474. PMID: 34988090; PMCID: PMC8720971.

CAMPMANS-KUIJPERS MJE, DIJKSTRA G. Food and Food Groups in Inflammatory Bowel Disease (IBD): The Design of the Groningen Anti-Inflammatory Diet (GrAID). Nutrients. 2021 Mar 25;13(4):1067. doi: 10.3390/nu13041067. PMID: 33806061; PMCID: PMC8064481.

CELIBERTO LS, GRAEF FA, HEALEY GR, BOSMAN ES, JACOBSON K, SLY LM, VALLANCE BA. Inflammatory bowel disease and immunonutrition: novel therapeutic approaches through modulation of diet and the gut microbiome. Immunology. 2018 Sep;155(1):36-52. doi: 10.1111/imm.12939. Epub 2018 May 16. PMID: 29693729; PMCID: PMC6099178.

CUOMO A, PARASCANDOLO I. Role of Nutrition in the Management of Patients with Chronic Musculoskeletal Pain. J Pain Res. 2024 Jun 25;17:2223-2238. doi: 10.2147/JPR.S456202. PMID: 38947129; PMCID: PMC11214565.

FEKETE M, SZARVAS Z, FAZEKAS-PONGOR V, FEHER A, CSIPO T, FORRAI J, DOSA N, PETERFI A, LEHOCZKI A, TARANTINI S, VARGA JT. Nutrition Strategies Promoting Healthy Aging: From Improvement of Cardiovascular and Brain Health to Prevention of Age-Associated Diseases. Nutrients. 2022 Dec 22;15(1):47. doi: 10.3390/nu15010047. PMID: 36615705; PMCID: PMC9824801.

GILL PA, INNISS S, KUMAGAI T, RAHMAN FZ, SMITH AM. The Role of Diet and Gut Microbiota in Regulating Gastrointestinal and Inflammatory Disease. Front Immunol. 2022 Apr 5;13:866059. doi: 10.3389/fimmu.2022.866059. PMID: 35450067; PMCID: PMC9016115.

GODALA M, GASZYŃSKA E, ZATORSKI H, MAŁECKA-WOJCIESKO E. Dietary Interventions in Inflammatory Bowel Disease. Nutrients. 2022 Oct 12;14(20):4261. doi: 10.3390/nu14204261. PMID: 36296945; PMCID: PMC9607252.

GYRIKI, D. et al. Exploring the Gut Microbiome’s Role in Inflammatory Bowel Disease: Insights and Interventions. J. Pers. Med. 2024, 14(5), 507; https://doi.org/10.3390/jpm14050507

JAWHARA S. How Do Polyphenol-Rich Foods Prevent Oxidative Stress and Maintain Gut Health? Microorganisms. 2024 Jul 31;12(8):1570. doi: 10.3390/microorganisms12081570. PMID: 39203412; PMCID: PMC11356206.

JAYAWARDENA D, DUDEJA PK. Micronutrient Deficiency in Inflammatory Bowel Diseases: Cause or Effect? Cell Mol Gastroenterol Hepatol. 2020;9(4):707-708. doi: 10.1016/j.jcmgh.2019.12.009. Epub 2020 Jan 18. PMID: 31962099; PMCID: PMC7212480.

JIANG, J., CHEN, L., CHEN, Y. et al. Exclusive enteral nutrition remodels the intestinal flora in patients with active Crohn's disease. BMC Gastroenterol 22, 212 (2022). https://doi.org/10.1186/s12876-022-02293-y

MCDOWELL C, FAROOQ U, HASEEB M. Inflammatory Bowel Disease. [Updated 2023 Aug 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470312/

MORARIU ID, AVASILCAI L, VIERIU M, LUPU VV, MORARIU BA, LUPU A, MORARIU PC, POP OL, STARCEA IM, TRANDAFIR L. Effects of a Low-FODMAP Diet on Irritable Bowel Syndrome in Both Children and Adults-A Narrative Review. Nutrients. 2023 May 13;15(10):2295. doi: 10.3390/nu15102295. PMID: 37242178; PMCID: PMC10223978.

NIELSEN OH, AINSWORTH M, COSKUN M, WEISS G. Management of Iron-Deficiency Anemia in Inflammatory Bowel Disease: A Systematic Review. Medicine (Baltimore). 2015 Jun;94(23):e963. doi: 10.1097/MD.0000000000000963. PMID: 26061331; PMCID: PMC4616486.

NÚÑEZ-SÁNCHEZ MA, MELGAR S, O'DONOGHUE K, MARTÍNEZ-SÁNCHEZ MA, FERNÁNDEZ-RUIZ VE, FERRER-GÓMEZ M, RUIZ-ALCARAZ AJ, RAMOS-MOLINA B. Crohn's Disease, Host-Microbiota Interactions, and Immunonutrition: Dietary Strategies Targeting Gut Microbiome as Novel Therapeutic Approaches. Int J Mol Sci. 2022 Jul 28;23(15):8361. doi: 10.3390/ijms23158361. PMID: 35955491; PMCID: PMC9369148.

PIGNEUR B, RUEMMELE FM. Nutritional interventions for the treatment of IBD: current evidence and controversies. Therap Adv Gastroenterol. 2019 Nov 25;12:1756284819890534. doi: 10.1177/1756284819890534. PMID: 31803252; PMCID: PMC6878599.

RANDENI N, BORDIGA M, XU B. A Comprehensive Review of the Triangular Relationship among Diet-Gut Microbiota-Inflammation. Int J Mol Sci. 2024 Aug 29;25(17):9366. doi: 10.3390/ijms25179366. PMID: 39273314; PMCID: PMC11394685.

SHAMS M, AHMED J, UMAR A, REHMAN A, SOHAIL K, JAVED B, MUSTAFA R, PAYAL F, SHEHRYAR A, KHAN M. Dietary Interventions in Irritable Bowel Syndrome: A Systematic Review of Clinical Outcomes, Microbiota Changes, and Inflammatory Markers. Cureus. 2024 Sep 30;16(9):e70568. doi: 10.7759/cureus.70568. PMID: 39483931; PMCID: PMC11524984.

SHAN Y, LEE M, CHANG EB. The Gut Microbiome and Inflammatory Bowel Diseases. Annu Rev Med. 2022 Jan 27;73:455-468. doi: 10.1146/annurev-med-042320-021020. Epub 2021 Sep 23. PMID: 34555295; PMCID: PMC10012812.

SOENS MA, SESSO HD, MANSON JE, FIELDS KG, BURING JE, LEE IM, COOK NR, KIM E, BUBES V, DUSHKES R, SERHAN CN, RATHMELL JP. The effect of vitamin D and omega-3 fatty acid supplementation on pain prevalence and severity in older adults: a large-scale ancillary study of the VITamin D and OmegA-3 triaL (VITAL). Pain. 2024 Mar 1;165(3):635-643. doi: 10.1097/j.pain.0000000000003044. Epub 2023 Oct 25.

STATOVCI D, AGUILERA M, MACSHARRY J, MELGAR S. The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces. Front Immunol. 2017 Jul 28;8:838. doi: 10.3389/fimmu.2017.00838. PMID: 28804483; PMCID: PMC5532387.

TAMBURINI B, LA MANNA MP, LA BARBERA L, MOHAMMADNEZHAD L, BADAMI GD, SHEKARKAR AZGOMI M, DIELI F, CACCAMO N. Immunity and Nutrition: The Right Balance in Inflammatory Bowel Disease. Cells. 2022 Jan 28;11(3):455.

WELLENS J, VISSERS E, MATTHYS C, VERMEIRE S, SABINO J. Personalized Dietary Regimens for Inflammatory Bowel Disease: Current Knowledge and Future Perspectives. Pharmgenomics Pers Med. 2023 Jan 12;16:15-27. doi: 10.2147/PGPM.S359365. PMID: 36660362; PMCID: PMC9842524.

WELLINGTON VNA, SUNDARAM VL, SINGH S, SUNDARAM U. Dietary Supplementation with Vitamin D, Fish Oil or Resveratrol Modulates the Gut Microbiome in Inflammatory Bowel Disease. Int J Mol Sci. 2021 Dec 24;23(1):206. doi: 10.3390/ijms23010206. PMID: 35008631; PMCID: PMC8745446.

WIĘCEK M, PANUFNIK P, POMORSKA K, LEWANDOWSKI K, RYDZEWSKA G. Diet as therapeutic intervention in Crohn's disease. Prz Gastroenterol. 2022;17(2):96-102. doi: 10.5114/pg.2022.116376. Epub 2022 May 19. PMID: 35664022; PMCID: PMC9165334.

WIERTSEMA SP, VAN BERGENHENEGOUWEN J, GARSSEN J, KNIPPELS LMJ. The Interplay between the Gut Microbiome and the Immune System in the Context of Infectious Diseases throughout Life and the Role of Nutrition in Optimizing Treatment Strategies. Nutrients. 2021 Mar 9;13(3):886. doi: 10.3390/nu13030886. PMID: 33803407; PMCID: PMC8001875.

ZHANG P. Influence of Foods and Nutrition on the Gut Microbiome and Implications for Intestinal Health. Int J Mol Sci. 2022 Aug 24;23(17):9588. doi: 10.3390/ijms23179588. PMID: 36076980; PMCID: PMC9455721.

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Published

2025-01-17

How to Cite

Martins Gomes Fredrich, I., Canale Medeiros, L. L., Maran Meira, M., Kirchesch e Costa, T. H., Salles Granzinoli, D., Hisi Fujii Ramos, A., Barbosa Wahl Witzler, C., Souza Arinos, I., Foletto, C., Farias Sene Lopes, J., Conciani de Oliveira, M. C., Corrêa Bueno, G., Fontes da Silva, M., & Avanci Júnior, J. A. (2025). Impact of Nutrition on the Management of Inflammatory Bowel Diseases. Brazilian Journal of Implantology and Health Sciences, 7(1), 1406–1420. https://doi.org/10.36557/2674-8169.2025v7n1p1406-1420

Issue

Vol. 7 No. 1 (2025): BJIHS QUALIS B3 - FATOR DE IMPACTO SJIF 5.807 - ÍNDICE H 22

Section

Literature Review

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Copyright (c) 2025 Isadora Martins Gomes Fredrich, Larah Luyza Canale Medeiros, Mariana Maran Meira, Thaís Helena Kirchesch e Costa, Diego Salles Granzinoli, Ana Hisi Fujii Ramos, Camila Barbosa Wahl Witzler, Isabele Souza Arinos, Caroline Foletto, Jonas Farias Sene Lopes, Maria Clara Conciani de Oliveira, Giovana Corrêa Bueno, Marcelo Fontes da Silva, José Amarildo Avanci Júnior

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