Tratamento cirúrgico de ceratocisto odontogênico associado a terapias adjuvantes

Authors

  • Lara Cristina Cipriano de Carvalho UNIVERSIDADE FEDERAL DO PIAUÍ
  • Nádia Maria Pires Silva UNIVERSIDADE FEDERAL DO PIAUÍ
  • Brunna da Silva Firmino UNIVERSIDADE FEDERAL DO PIAUÍ
  • Thálison Ramon de Moura Batista UNIVERSIDADE FEDERAL DO PIAUÍ
  • Thaís Cristina Araújo Moreira UNIVERSIDADE FEDERAL DO PIAUÍ
  • Helana Maria Ponte Barros Ribeiro UNIVERSIDADE FEDERAL DO PIAUÍ
  • Gustavo Renan da Silva Mineiro UNIVERSIDADE FEDERAL DO PIAUÍ
  • ⁠Francisca Ananda da Silva Leal UNIVERSIDADE FEDERAL DO PIAUÍ
  • ⁠Cyntia Natyelle Fernandes Sobrinho
  • Matheus Feitosa Ramos Xavier UNIVERSIDADE FEDERAL DO PIAUÍ

DOI:

https://doi.org/10.36557/2674-8169.2025v7n1p1696-1708

Keywords:

Cistos odontogênicos, Crioterapia, Mandíbula.

Abstract

INTRODUCTION: The odontogenic keratocyst is a benign but aggressive and recurrent cyst. Common in men aged 10 to 59, it frequently affects the mandible, especially in the angle region. The lesion can be symptomatic or asymptomatic, radiographically appearing as a well-defined radiolucent area. The diagnosis is confirmed by biopsy and histopathology, and treatment usually involves enucleation and adjuvant therapies. The aim of this study is to report the surgical approach associated with adjuvant therapies as a treatment for odontogenic keratocyst, through a clinical case. CASE REPORT: A 28-year-old male patient, without comorbidities, with severe trismus, purulent discharge and edema sought outpatient care at the University Hospital of the Federal University of PIauí (HU-UFPI). Imaging tests showed a multilocular radiolucent lesion in the right mandible, associated with resorption of the tooth roots. The diagnosis was odontogenic keratocyst and the treatment involved enucleation, peripheral ostectomy and cryotherapy. CONCLUSION: Odontogenic keratocysts, although benign, require rigorous surgical treatment to prevent recurrences. The combination of enucleation, peripheral ostectomy and cryotherapy proved effective in removing the lesion and preserving bone tissue.

Downloads

Download data is not yet available.

References

VERED, Marilena; WRIGHT, John M. Update from the 5th edition of the World Health Organization classification of head and neck tumors: odontogenic and maxillofacial bone tumours. Head and neck pathology. 2022; 16(1): 63-75.

GOLDBERG, Leonard H. et al. Resolution of odontogenic keratocysts of the jaw in basal cell nevus syndrome with GDC-0449. Archives of dermatology. 2011; 147(7); 839-841.

MEARA, John G. et al. The odontogenic keratocyst: a 20‐year clinicopathologic review. The Laryngoscope. 1998; 108 (2): 280-283.

MENON, Suresh. Keratocystic odontogenic tumours: etiology, pathogenesis and treatment revisited. Journal of maxillofacial and oral surgery. 2015; 14: 541-547.

SHEAR, Mervyn. Odontogenic keratocysts: natural history and immunohistochemistry. Oral and Maxillofacial Surgery Clinics. 2003; 15 (3): 347-362.

STOELINGA, Paul JW. Etiology and pathogenesis of keratocysts. Oral and Maxillofacial Surgery Clinics. 2003; 15 (3): 317-324.

BROWNE, R. M. The pathogenesis of odontogenic cysts: a review. Journal of Oral Pathology & Medicine. 1975; 4 (1): 31-46.

KAIBUCHI-ANDO, Kaori et al. Odontogenic keratocysts are an important clue for diagnosing basal cell nevus syndrome. Nagoya journal of medical science. 2021; 83(2): 393.

BOFFANO, Paolo et al. The epidemiology and management of odontogenic keratocysts (OKCs): a European multicenter study. Journal of Cranio-Maxillofacial Surgery. 2022; 50 (1): 1-6.

SHEAR, Mervyn. Odontogenic keratocysts: clinical features. Oral and maxillofacial Surgery Clinics. 2003; 15 (3): 335-345.

LIRA, Alexandre Aires Braga de et al. Tumor odontogênico ceratocístico. RSBO (Online). 2010; 7 (1): 95-99.

Menon S. Keratocystic odontogenic tumours: etiology, pathogenesis and treatment revisited. J Maxillofac Oral Surg. 2015; 14(3): 541-7.

Habibi A, Saghravanian N, Habibi M, Mellati E, Habibi M. Keratocystic odontogenic tumor: a 10-year retrospective study of 83 cases in an Iranian population. J Oral Sci. 2007; 49(3): 229-35.

Kunihiro T, Kawana H, Kodaka R, Oba T. Keratocystic odontogenic tumor invading the maxillary sinus: a case report of collaborative surgery between an oral surgeon and an otorhinolaryngologist. J UOEH. 2014; 36(4): 251-6.

(16) Titinchi F. Protocol for management of odontogenic keratocysts considering recurrence according to treatment methods. J Korean Assoc Oral Maxillofac Surg 2020; 46: 358–360.

(17) Kaczmarzyk T, Mojsa I, Stypulkowska J: A systematic review of the recurrence rate for keratocystic odontogenic tumour in relation to treatment modalities. Int J Oral Maxillofac Surg 41(6): 756e767, 2012.

(18) Tarakji B, Baroudi K, Hanouneh S et al (2013) Possible recurrence of keratocyst in nevoid basal cell carcinoma syndrome: a review of literature. Eur J Dent 07:S126–S134. https://doi.org/10. 4103/1305-7456.119090

(19) Al-Moraissi EA, Dahan AA, Alwadeai MS, Oginni FO, Al-Jamali JM, Alkhutari AS, Al-Tairi NH, Almaweri AA, Al-Sanabani JS. What surgical treatment has the lowest recurrence rate following the management of keratocystic odontogenic tumor?: A large systematic review and meta-analysis. J Craniomaxillofac Surg. 2017 Jan;45(1):131-144. doi: 10.1016/j.jcms.2016.10.013. Epub 2016 Oct 31. PMID: 27955959.

(20) Chrcanovic BR, Gomez RS. Recurrence probability for keratocystic odontogenic tumors: An analysis of 6427 cases. J Craniomaxillofac Surg. 2017;45:244-51

(21) Karaca C, Dere KA, Er N, Aktas A, Tosun E, Koseoglu OT, Usubutun A. Recurrence rate of odontogenic keratocyst treated by enucleation and peripheral ostectomy: Retrospective case series with up to 12 years of follow-up. Med Oral Patol Oral Cir Bucal. 2018 Jul 1;23(4):e443-e448. doi: 10.4317/medoral.22366. PMID: 29924761; PMCID: PMC6051675.

(22) Garcia CB, Gignon VF, Melo MR, Costa SAA, Costa JMC, Patrocínio LG. Tumor odontogênico queratocístico extenso de mandíbula: enucleação associada à crioterapia. Rev Bras Cir Craniomaxilofac. 2011; 14(1):60-2

(23) Clínico A, Nogueira EF de C, Maranhão CM de CT, et al. Brazilian Journal of Oral and Maxillofacial Surgery -BrJOMS.; 2020.

(24) COSTA FWG, et al. Cryosurgery in treatment of benign jaw lesions: literature review and analyze of 103 cases previously reported. RSBO, 7(2): 208-215, 2010.

(25) EFFIOM, O. et al. Ameloblastoma: current etiopathological concepts and management. Oral Diseases, v. 24, n. 3, p. 307–316, 9 mar. 2017a.

(26) Ledderhof, N.J., et al., Topical 5-Fluorouracil is a Novel Targeted Therapy for the Keratocystic Odontogenic Tumor. J Oral Maxillofac Surg, 2017. 75(3): p. 514-524.

Published

2025-01-22

How to Cite

Cristina Cipriano de Carvalho, L., Maria Pires Silva , N., da Silva Firmino, B., Ramon de Moura Batista, T., Cristina Araújo Moreira , T., Maria Ponte Barros Ribeiro, H., Renan da Silva Mineiro, G., Ananda da Silva Leal, ⁠Francisca, Natyelle Fernandes Sobrinho, ⁠Cyntia, & Feitosa Ramos Xavier, M. (2025). Tratamento cirúrgico de ceratocisto odontogênico associado a terapias adjuvantes . Brazilian Journal of Implantology and Health Sciences, 7(1), 1696–1708. https://doi.org/10.36557/2674-8169.2025v7n1p1696-1708