Intestinal Microbiota and Its Influence on Human Health and Autism Spectrum Disorder (ASD)
DOI:
https://doi.org/10.36557/2674-8169.2024v6n12p1115-1143Keywords:
gut microbiota, Autism spectrum disorder (ASD), DysbiosisAbstract
Introduction: The intestinal microbiota plays a crucial role in human health, influencing digestion, metabolism, immune system development, and even behavior. This review aims to explore the relationship between gut microbiota and Autism Spectrum Disorder (ASD), emphasizing its potential role in the development and manifestation of ASD symptoms through immunological and metabolic pathways. Methods: Data for this review were obtained from PubMed and Science Direct, covering literature from 2011 to 2024. Inclusion criteria focused on original studies, systematic reviews, and meta-analyses discussing gut microbiota composition, dysbiosis, and its relationship with ASD. Articles were selected based on relevance, language (English or Portuguese), and the presence of empirical data. Results: The review identified 36 articles that highlight the diversity and vital functions of the gut microbiota. Dysbiosis, an imbalance in the gut microbiota, is associated with gastrointestinal issues, metabolic disorders, and neuropsychiatric conditions, including ASD. Studies indicate that children with ASD have distinct gut microbiota compositions, with reduced diversity and specific bacterial imbalances. These changes may contribute to ASD symptoms through the gut-brain axis, affecting neurotransmitter production and immune responses. Discussion: Maintaining a balanced gut microbiota is essential for overall health, and modulating the microbiota may offer therapeutic benefits for managing ASD symptoms. The changes in gut microbiota observed in individuals with ASD suggest a potential link between gut health and neuropsychiatric symptoms, highlighting the importance of dietary and probiotic interventions in maintaining gut health. Conclusion: This review underscores the potential of the gut microbiota as a therapeutic target in ASD and the importance of dietary and probiotic interventions in maintaining gut health. Further research is necessary to fully understand these interactions and develop effective microbiota-based treatments, emphasizing the need for personalized approaches in clinical applications.
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Copyright (c) 2024 CARINA TOLEDO SCOPARO BARIONI, Renata Paes de Barros Wandresen, Barbara Bruna de Araújo Oliveira Kubo, Amanda Franceschi Coimbra, Altair Rogério Ambrosio, Tatiana Monteiro Arns de Miranda
This work is licensed under a Creative Commons Attribution 4.0 International License.
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