Psychiatry and Neuroscience: The Role of Neuroinflammation in Depression and Bipolar Disorder

Authors

  • Bernardo Correia Pereira
  • Maria Clara Queiroz Brandão
  • José Hamilton de Figueiredo Viana
  • Fernando Malachias de Andrade Bergamo
  • Jennifer Cristiana Vicente de Lima
  • João Kleber Silva Schuenck
  • Sophia Junqueira Araújo
  • Charles Bonatti do Vale Silva
  • Nayra Lurian Nascimento de Souza
  • Rhuan Nantes Fontoura Teofilo Não se aplica
  • Carolina Dossena

DOI:

https://doi.org/10.36557/2674-8169.2024v6n11p3083-3094

Keywords:

neuroinflamação, DEPRESSÃO, Biomarcadores, Bipolar, Manejo, Emergência.

Abstract

Introduction: Depression and bipolar disorder are common psychiatric conditions with a major impact on mental health and quality of life. Neuroinflammation has been identified as an important factor in the pathogenesis of these conditions. Microglial activation and release of inflammatory cytokines in the central nervous system are associated with neurochemical alterations that may contribute to depressive symptoms and mood instability in bipolar disorder. Objectives: This article aims to: (1) investigate the role of neuroinflammation in the pathogenesis of depression and bipolar disorder; (2) compile and evaluate the clinical evidence on neuroinflammation in these conditions; (3) identify the neurobiological mechanisms involved; (4) evaluate therapeutic interventions that modulate neuroinflammation; (5) promote an integrated approach considering biological, psychological and social factors in the management of depression and bipolar disorder. Methodology: A systematic review of the literature was performed in the BVS, Medline, Pubmed, LILACS and Google Scholar databases. Inclusion criteria included studies published between 2010 and 2023 on neuroinflammation in relation to depression and bipolar disorder. Data analysis was qualitative, focusing on comparisons between mechanisms and therapeutic interventions. Results: The review showed that neuroinflammation plays a central role in depression and bipolar disorder, with microglial activation and inflammatory cytokine release associated with symptom severity. Inflammatory markers are elevated in patients with these conditions, suggesting that neuroinflammation may be an important biomarker for diagnosis and prognosis. Interventions to reduce neuroinflammation, such as anti-inflammatory drugs and non-pharmacological approaches, have shown promise in improving symptoms. Conclusion: Neuroinflammation is a promising area of ​​research in psychiatry and neuroscience, with great potential to improve the understanding and treatment of depression and bipolar disorder. Modulation of the inflammatory response in the central nervous system offers new therapeutic opportunities. Continued research is essential to develop innovative and effective therapeutic strategies for patients.

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Published

2024-11-24

How to Cite

Correia Pereira, B., Queiroz Brandão, M. C., de Figueiredo Viana, J. H., Malachias de Andrade Bergamo, F., Cristiana Vicente de Lima , J., Kleber Silva Schuenck, J., Junqueira Araújo, S., Bonatti do Vale Silva , C., Lurian Nascimento de Souza , N., Teofilo, R. N. F., & Dossena, C. (2024). Psychiatry and Neuroscience: The Role of Neuroinflammation in Depression and Bipolar Disorder. Brazilian Journal of Implantology and Health Sciences, 6(11), 3083–3094. https://doi.org/10.36557/2674-8169.2024v6n11p3083-3094

Issue

Vol. 6 No. 11 (2024): BJIHS QUALIS B3 - FATOR DE IMPACTO SJIF 5.807 - ÍNDICE H 22

Section

Systematic Review

License

Copyright (c) 2024 Rhuan Teofilo, Bernardo Correia Pereira, Maria Clara Queiroz Brandão, José Hamilton de Figueiredo Viana, Fernando Malachias de Andrade Bergamo, Jennifer Cristiana Vicente de Lima , João Kleber Silva Schuenck, Sophia Junqueira Araújo, Charles Bonatti do Vale Silva , Nayra Lurian Nascimento de Souza , Carolina Dossena

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