Keywords
Surgical treatment
Quality of life
Self-image
How to Cite
Abstract
Penile cancer is a rare condition, but it has profound impacts on patients' quality of life, mainly due to treatment options. Conservative approaches and radical surgery have different implications for patients' sexual function, self-image and psychological well-being. This study aimed to compare the impact of conservative treatments and radical surgery on the quality of life of patients with penile cancer. An integrative review was carried out using the PubMed, Scopus and Scielo databases, covering publications from 2012 to 2024, in English and Portuguese. Clinical trials, observational studies, systematic reviews and meta-analyses addressing the impact of conservative and radical treatments on the quality of life of patients with penile cancer were included. The data extracted included patient characteristics, type of treatment and quality of life outcomes.The review indicated that conservative treatments, such as partial penectomy and organ preservation, result in better preservation of sexual function and self-image, with up to 80% of patients reporting significant maintenance of these functions. On the other hand, total penectomy has been shown to be effective for cancer control in advanced cases, but associated with more serious psychological and social impacts, with around 70% of patients reporting changes in self-image and quality of life. This review points out that in cases of early-stage or localized penile cancer, conservative treatments present a viable alternative, balancing disease control with less impact on quality of life. The choice of treatment should take into account not only the stage of the disease, but also the patient's preferences and the expected impact on their quality of life.
References
Necchi A, Nicolai N, Colecchia M, et al. Prognostic factors in squamous cell carcinoma of the penis: Analysis of penile cancer cases treated at the National Cancer Institute of Milan. Urol Oncol [Internet]. 2013 [cited 2024 Nov 1];31(7):1141-50. Available from: https://doi.org/10.1016/j.urolonc.2012.01.009.
Audenet F, Sfakianos JP, Jacob B, et al. Treatment of penile carcinoma: Current practice and emerging trends. Curr Opin Oncol [Internet]. 2014 [cited 2024 Nov 1];26(3):284-9. Available from: https://doi.org/10.1097/CCO.0000000000000070.
Kieffer JM, Djajadiningrat RS, Van Muilekom EA, et al. Quality of life for patients treated for penile cancer. J Urol [Internet]. 2014 [cited 2024 Nov 1];192(4):1105-10. Available from: https://doi.org/10.1016/j.juro.2014.04.091.
Nicholson S, Tornari C, Farahani L, et al. Quality of life and psychosocial outcomes in men treated for penile cancer: A systematic review. Eur J Cancer Care (Engl) [Internet]. 2019 [cited 2024 Nov 1];28(1). Available from: https://doi.org/10.1111/ecc.12974.
Dräger DL, Sievert KD, Hakenberg OW. Organ-sparing surgical approaches in penile cancer and their impact on quality of life. Curr Opin Urol [Internet]. 2021 [cited 2024 Nov 1];31(2):141-6. Available from: https://doi.org/10.1097/MOU.0000000000000838.
Hu JC, Chang SL, Perez N, et al. Comparative effectiveness of penile-preserving surgery versus radical surgery for penile cancer. J Urol [Internet]. 2020 [cited 2024 Nov 1];203(5):964-70. Available from: https://doi.org/10.1097/JU.0000000000000702.
Lopes A, Hidalgo GS, Carvalho JF, et al. Organ-preserving surgery in penile cancer: A contemporary update. Transl Androl Urol [Internet]. 2022 [cited 2024 Nov 1];11(5):1328-34. Available from: https://doi.org/10.21037/tau-22-189.
D'Andrea D, Soria F, Zecchetto C, et al. Patient-reported outcomes in penile cancer survivors following conservative versus radical surgical approaches. BJU Int [Internet]. 2023 [cited 2024 Nov 1];132(2):225-33. Available from: https://doi.org/10.1111/bju.16021.
Davies AH, Zoubeidi A, Chi KN. Impact of radical and conservative surgery on quality of life in penile cancer: A focus on outcomes and future perspectives. Nat Rev Urol [Internet]. 2016 [cited 2024 Nov 1];13(9):635-47. Available from: https://doi.org/10.1038/nrurol.2016.148.
Pettaway CA, Crook JM, Pagliaro LC, et al. Management of penile cancer: The importance of quality-of-life considerations in treatment selection. Lancet Oncol [Internet]. 2015 [cited 2024 Nov 1];16(2). Available from: https://doi.org/10.1016/S1470-2045(14)71194-9.
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Copyright (c) 2024 Luca Murad Tambellini, Lucas Costa de Santana, Marcelo Santos Marques de Oliveira, Eduardo Gomes da Silva Marques, Beatriz Centeno Santos, Enzzo Campagnaro, Camila Vidoski, Felipe Russo Nogueira, Leonardo da Silva Toniolo, Guilherme Balhester, Júlia Eleutério Silva, Lucas Pereira Marcello, Henrique Rivera Simões, Beatriz Gregório Franco Gabarron, Gabriela Teles Barbosa, Arun Quadros Darian, Guilherme Santana da Costa, Pedro Ziolli Del Massa, Diego Simha Ghiberti, Luciano Lopes Oliveira Júnior, Raphael Augusto Graciano Pereira, Lucas Tadeu Bohelmann Forenza, João Pedro Alves Gatto, Giovanni Amadeu Christini