Keywords
hydrops fetalis
neonate
antiviral
How to Cite
Abstract
Human cytomegalovirus (HCMV) is a significant cause of congenital and perinatal infections globally, being the most frequent and severe intrauterine viral infection among newborns. The clinical findings in symptomatic neonates are nonspecific and may include petechiae and fetal hydrops. This study aims to present a clinical case report of a male newborn who, at birth, did not cry and showed no muscle tone. The patient presented with cyanosis, meconium, a heart rate of less than 100 bpm, and, even after initial care, showed no clinical improvement, necessitating admission to the ICU. On the eighth day, petechiae appeared, and laboratory tests identified the presence of HCMV through urine PCR. Treatment with Ganciclovir allowed for discharge from the ICU after 21 days of use. It is concluded that prompt attention to warning signs, early diagnosis, proper management of complications, and timely application of the correct treatment are essential to ensure a favorable patient outcome.
References
Cruz, R. P. D. (2024). Infecção por citomegalovírus: patogênese e diagnóstico da infeção congênita. (Doctoral dissertation).
Demmler-Harrison, G. J. (2024). Congenital cytomegalovirus (cCMV) infection: Clinical features and diagnosis. UpToDate. Retrieved September 04, 2024, from Congenital cytomegalovirus (cCMV) infection: Clinical features and diagnosis - UpToDate
Figueiredo, C. G. (2020). Detecção de Citomegalovírus humano em recém-nascidos. (Doctoral dissertation).
Friel, T. J. (2017). Epidemiology, clinical manifestations, and treatment of cytomegalovirus infection in immunocompetent adults. UpToDate. Retrieved August 05, 2024, from Epidemiology, clinical manifestations, and treatment of cytomegalovirus infection in immunocompetent adults - UpToDate
Izaias, D. R. M. (2024). Prevalência de Herpervírus tipo 4, 5 e 6 em transplantados renais. (Doctoral dissertation).
Krishna, B. A., Wills, M. R., & Sinclair, J. H. (2019). Advances in the treatment of cytomegalovirus. British Medical Bulletin, 131(1), 5-17. doi: 10.1093/bmb/ldz031
Leruez-Ville, M., Chatzakis, C., Lilleri, D., Blazquez-Gamero, D., Alarcon, A., Bourgon, N., ... & Vossen, A. (2024). Consensus recommendation for prenatal, neonatal and postnatal management of congenital cytomegalovirus infection from the European congenital infection initiative (ECCI). The Lancet Regional Health–Europe, 40. doi: 10.1016/j.lanepe.2024.100974.
Lockwood, C. J., & Običan, S. G. (2024) Nonimmune hydrops fetalis. UpToDate. Retrieved June 03, 2024, from Nonimmune hydrops fetalis - UpToDate.
Pinninti, S., & Boppana, S. (2022). Congenital cytomegalovirus infection diagnostics and management. Current opinion in infectious diseases, 35(5), 436–441. https://doi.org/10.1097/QCO.0000000000000874.
Speer, M. (2023). Nonimmune hydrops fetalis in the neonate: Causes, presentation, and overview of neonatal management. UpToDate. Retrieved September 17, 2023, from Nonimmune hydrops fetalis in the neonate: Causes, presentation, and overview of neonatal management - UpToDate.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2024 MARIANA MALVEZZI, VICTOR SOUZA DACROCE, RICARDO ENRIQUE GIMENES DA SILVA, GIULIA BOITO DE OLIVEIRA, GIULIA ROBERTA PEREIRA, MYLENA SOARES DE ANDRADE NICOLAU, CARLOS ALBERTO CALDEIRA BRANT, HELOISA SANDES GROSSI, NAYANDRA MALTA MASCARENHAS, LARYSSA CANO LAVERDE, EDUARDA MASSI BATISTA, RHAREZA PIOLI GUARINI, HELOÍSA LOPACINSKI WATANABE, ANA BEATRIZ MORETI, MARINA BOITO DE OLIVEIRA, LUIZA FATIMA KROKOSCZ MARTIGNON, MARIA LUIZA BOM-AMI BARROS MEES, KELSON RUDY FERRARINI , JÉSSICA DE ALMEIDA KULEVICZ, ANA RAFAELLA DE PÁDUA, MARIÉLEN EDUARDA PRIETO PEREIRA