Keywords
Pneumonia
Elderly
Systematic review
How to Cite
Abstract
Pneumonia is one of the most common illnesses and one of the main causes of hospitalizations among the elderly. In view of the frequent prescription for the elderly, the possibility of an increased risk of pneumonia due to the use of anticholinergic drugs is an important field of study. This systematic review aims to investigate the association between the use of anticholinergic drugs and the risk of pneumonia in elderly patients. A search was carried out in the PubMed, Web of Science, EBSCO and Google Scholar databases and based on the PRISMA tool and the application of inclusion and exclusion criteria, 6 articles were selected for analysis and discussion. It is inferred that the risk of pneumonia is increased in elderly patients who use anticholinergic drugs, especially more potent anticholinergics and in the treatment initiation phase. Physicians and other health professionals should take this evidence into account in clinical practice with elderly patients.
References
Simonetti AF et al.. Management of community-acquired pneumonia in older adults. Ther Adv Infect Dis. 2014;2(1):1–9.
Torres A et al.. Risk factors for community-acquired pneumonia in adults in Europe: a literature review. Thorax. 2013;68(11):1057–1065.
Fick DM et al.. American geriatrics society 2019 updated AGS beers criteria (R) for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2019;67(4):674–694.
Moher D et al.. Preferred reporting items for systematic reviews and Meta-Analyses: the PRISMA statement (reprinted from annals of internal medicine). Phys Ther. 2009;89(9):873–880.
Paul KJ et al.. Anticholinergic medications and risk of community-acquired pneumonia in elderly adults: a population-based case-control study. J Am Geriatr Soc. 2015;63(3):476–485.
Chatterjee S et al.. Anticholinergic medication use and risk of pneumonia in elderly adults: a nested case-control study. J Am Geriatr Soc. 2016;64(2):394–400.
Lampela P et al.. Anticholinergic exposure and risk of pneumonia in persons with Alzheimer’s disease: a nested case-control study. J Alzheimers Dis. 2017;56(1):119–128.
Kose E et al.. Assessment of aspiration pneumonia using the anticholinergic risk scale. Geriatr Gerontol Int. 2018;18(8):1230–1235.
Lee CY et al.. The prevalence of anticholinergic drugs and correlation with pneumonia in elderly patients: a population-based study in Taiwan. IJERPH. 2020;17(17):6260.
Gradek-Kwinta E et al.. The use of anticholinergic medication is associated with an increased risk of stroke-associated pneumonia. Aging Clin Exp Res. 2022;34(8):1935–1938.
Jackson ML et al.. The burden of community-acquired pneumonia in seniors: results of a population-based study. Clin Infect Dis. 2004;39(11):1642–1650.
Almirall J et al.. New evidence of risk factors for community-acquired pneumonia: a population-based study. Eur Respir J. 2008;31(6):1274–1284.
Lampela P et al.. Anticholinergic drug use, serum anticholinergic activity, and adverse drug events among older people: a population-based study. Drugs Aging. 2013;30(5):321–330.
Salahudeen MS, Duffull SB, Nishtala PS. Anticholinergic burden quantified by anticholinergic risk scales and adverse outcomes in older people: a systematic review. BMC Geriatr. 2015;15(1):31.
Castejon-Hernandez S et al.. Association between anticholinergic burden and oropharyngeal dysphagia among hospitalized older adults. Aging Clin Exp Res. 2021;33(7):1981–1985.
Riquelme R et al.. Community-acquired pneumonia in the elderly - A multivariate analysis of risk and prognostic factors. Am J Respir Crit Care Med. 1996;154(5):1450–1455.
Huxley EJ et al.. Pharyngeal aspiration in normal adults and patients with depressed consciousness. Am J Med. 1978;64(4):564–568.
Marik PE, Kaplan D. Aspiration pneumonia and dysphagia in the elderly. Chest. 2003;124(1):328–336.
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Copyright (c) 2023 Edinho Pereira Pardin , Brenda Zanatta Barbosa , Robson Pereira dos Santos , Guilherme Sell de Mendonça e Silva , Lara Thaís Marcon , Lucas Pilatti Kolossovski , Betina Villaca Monteiro , Cibele Leite Marsura , Emanuel Racim Munhoz , Fábio Felber Retroz, Helton Freitas Queiroz , Luiza Racim Munhoz , Ailla Gabrielli Costa Silva , Ana Vitória Machado Duarte, Felipe Cardoso Rodrigues Vieira
