Keywords
Leukemia
Oral Surgery
How to Cite
Abstract
Introduction: Osteonecrosis of the jaws (ONM) is a pathological condition characterized by the necrosis of bone tissue due to the interruption of blood supply, resulting in bone exposure that does not heal within eight weeks. This condition is often associated with the use of medications such as bisphosphonates, antiangiogenics, and chemotherapeutics, which are essential in the treatment of oncological diseases, especially leukemia. Objective: The objective of this study is to review the existing literature on osteonecrosis of the jaws induced by antiangiogenics and chemotherapeutics used in the treatment of leukemia, highlighting the main aspects related to the diagnosis, treatment, and prevention of this condition. Methods: An integrative literature review was conducted using PRISMA guidelines. The research was carried out in the PubMed, BVS, and SciELO databases, combining the descriptors "Bisphosphonate-Associated Osteonecrosis of the Jaw" and "Leukemia," combined with the boolean operator "AND." Articles published from 2014 to 2024 that were available in full text and in English or Portuguese, and that addressed the guiding question, were included. Studies involving animals or literature reviews were excluded. Results and Discussion: The initial search identified 23 studies, of which 6 articles were included for final analysis. The analyzed articles revealed a significant association between the use of chemotherapeutics and antiangiogenics and an increased risk of ONM, highlighting the need for appropriate interventions, such as medication suspension and conservative surgeries. Conclusion: The reviewed studies suggest that early identification of ONM signs and the implementation of preventive measures are essential to improve clinical outcomes and the quality of life of patients. Collaboration between oral health professionals and oncologists is essential to minimize the risks associated with ONM.
References
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Copyright (c) 2024 Maria Luiza Oliveira da Silva, Maysa Carolina Cosme Melo dos Santos, Matheus Nole dos Santos Mota, Flávio José de Souza Barbalho Filho, Helen Vitória Inácio Barros da Silva, Williane Félix Dias de Souza, Isabelle Lima Vasconcelos de Almeida, Chiu Tzyy Haur, Lorenna Beatriz de Castro Santos, Thammirys Pinheiro Melo Guerreiro, Larissa Oliveira Falcão, Amanda Rago Constantino Martins, Deusdete Mayara de Oliveira, Ana Carolina Corrêa Barbosa, Laura Aguiar Neves, Luan Rodrigues de Sousa, Matheus Andrade Rodrigues
