MANAGEMENT OF CELIAC DISEASE: A NARRATIVE REVIEW
DOI:
https://doi.org/10.36557/2674-8169.2024v6n9p3102-3119Keywords:
Celiac Disease; Chronic; Diagnosis; Treatment.Abstract
Celiac disease (CD), also known as gluten-sensitive enteropathy, is an autoimmune condition affecting the small intestine triggered by gluten ingestion in genetically predisposed individuals. The diagnosis of CD has advanced with the development of serological tests, intestinal biopsies, and HLA-DQ2 and HLA-DQ8 genotyping. The prevalence of CD has been increasing globally, with symptoms ranging from classic gastrointestinal issues to extraintestinal manifestations, complicating diagnosis. Current treatment is limited to a lifelong gluten-free diet (GFD), though adherence can be challenging due to cross-contamination and impacts on quality of life. Approximately 20% of patients may not respond to the GFD, leading to refractory celiac disease. Research into alternative therapies, such as gluten-degrading enzymes and tolerance-inducing vaccines, is ongoing. CD is often associated with other autoimmune conditions, necessitating continuous multidisciplinary monitoring. This review addresses the management of CD, highlighting diagnostic and therapeutic advancements while exploring the challenges faced by patients.
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Copyright (c) 2024 Yuri cordeiro Fonseca, Henrique Marreiros Veloso Carneiro, João Henrique de Almeida Navega, Matheus Garcia Carrera
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