Impact of Sleep on Muscle Regeneration in Patients with Chronic Diseases

Abstract

This work aims to explore how sleep influences health and muscle regeneration in patients with chronic diseases, providing a comprehensive view of the physiological and biochemical interactions involved. The research was conducted using databases such as Scielo, BVS (Virtual Health Library), and PubMed. For the search, descriptors from DeSC (Health Sciences Descriptors) were used, including "Sleep Initiation and Maintenance Disorders," "Muscle Development," "Chronic Disease," and "Sleep-Inducing Drugs." Additionally, the selection of articles was refined with specific filters, considering Portuguese and English languages, as well as the publication period between 2020 and 2024. Muscle regeneration is essential for maintaining function and mobility in patients with chronic diseases, such as fibromyalgia, muscular dystrophy, and rheumatoid arthritis. The body's ability to recover is influenced by various factors, with sleep being one of the most important. During sleep, the body carries out several vital physiological processes for muscle regeneration, including the release of anabolic hormones, muscle protein synthesis, and the repair of micro-injuries caused by physical activity. This study presents an integrative literature review with the purpose of analyzing the impact of sleep on muscle regeneration in patients with chronic diseases. Muscle regeneration in patients with chronic diseases is a complicated and often impaired process, which can significantly affect these individuals' quality of life. Sleep plays a fundamental role in this process, directly influencing the body's ability to recover and regenerate. Therefore, understanding how sleep impacts muscle regeneration is crucial for developing better therapeutic approaches and improving clinical outcomes for these patients.