Impact of concomitant use of vancomycin and TZP on the development of acute kidney injury: an integrative review

Authors

  • Júlia Leandra Fernandes Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • Mateus Pozza Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • José Henrique Beserra Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • Carolina Leite de Oliveira Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • Victor Hugo Mundim Melo Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • Maria Luiza Bertozi Francisco Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • Alex Italo da Silveira Sales Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • Gabrielly Alves Trigo Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • Rodrigo Cordon Isaac Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • André Breda Bauab Filho Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • Sabrina Furtunato de Oliveira Graduando em Medicina pelo Centro Universitário de Maceió
  • Maria Eduarda Almeida Cavalcanti Graduando em Medicina pelo Centro Universitário de Maceió
  • Tarcísio Fernando Honorio da Silva Graduando em Medicina pelo Centro Universitário de Maceió
  • Allycia Jamylle Nogueira de Mello Graduando em Medicina pelo Centro Universitário de Maceió
  • Paula Rafaela Nunes do Carmo Graduando em Medicina pelo Centro Universitário de Maceió
  • Lucas dos Santos Silva Graduando em Medicina pelo Centro de Estudos Superiores de Maceió
  • Lucélia Barros Tenório Graduando em Medicina pelo Centro de Estudos Superiores de Maceió
  • Bruna Michelly de Barros Canuto Pinheiro Graduando em Medicina pelo Centro de Estudos Superiores de Maceió
  • Lara Amaral Santos Cunha Graduando em Medicina pelo Centro de Estudos Superiores de Maceió

DOI:

https://doi.org/10.36557/2674-8169.2024v6n9p1097-1105

Keywords:

vancomycin; piperacillin-tazobactam; acute kidney injury

Abstract

Introduction: Vancomycin is a glycopeptide antibiotic widely used in the treatment of serious infections caused by Gram-positive microorganisms, including resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA). However, its prolonged use or at inadequate doses is associated with a series of adverse effects, with acute kidney injury (AKI) being one of the most worrying complications. Objective: To analyze the use of vancomycin and piperacillin-tazobactam combination therapy in acute kidney injury. Methodology: This is a literature review that included clinical trials in English and Portuguese, published between 2016 and 2024, selected from the PubMed, Scopus and SciELO databases. After careful selection, 8 articles were chosen to compose this literature review. Results: The combination of vancomycin with piperacillin-tazobactam (TZP) is associated with an increased risk of acute kidney injury (AKI) in critically ill pediatric and adult patients, especially when compared with other antibiotic combinations. Considerations: The combination of vancomycin with TZP is associated with an increased risk of acute kidney injury. It is crucial to closely monitor renal function during therapy with this combination and to consider alternatives with a lower risk of AKI, such as vancomycin with meropenem or ceftriaxone.

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References

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Published

2024-09-03

How to Cite

Fernandes , J. L., Mateus Pozza, José Henrique Beserra, Carolina Leite de Oliveira, Victor Hugo Mundim Melo, Maria Luiza Bertozi Francisco, Alex Italo da Silveira Sales, Gabrielly Alves Trigo, Rodrigo Cordon Isaac, André Breda Bauab Filho, Sabrina Furtunato de Oliveira, Maria Eduarda Almeida Cavalcanti, Tarcísio Fernando Honorio da Silva, Allycia Jamylle Nogueira de Mello, Paula Rafaela Nunes do Carmo, Lucas dos Santos Silva, Lucélia Barros Tenório, Bruna Michelly de Barros Canuto Pinheiro, & Lara Amaral Santos Cunha. (2024). Impact of concomitant use of vancomycin and TZP on the development of acute kidney injury: an integrative review. Brazilian Journal of Implantology and Health Sciences, 6(9), 1097–1105. https://doi.org/10.36557/2674-8169.2024v6n9p1097-1105

Issue

Vol. 6 No. 9 (2024): BJIHS QUALIS B3 - FATOR DE IMPACTO SJIF 5.807

Section

Original article

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Copyright (c) 2024 Júlia Leandra Fernandes , Mateus Pozza, José Henrique Beserra, Carolina Leite de Oliveira, Victor Hugo Mundim Melo, Maria Luiza Bertozi Francisco, Alex Italo da Silveira Sales, Gabrielly Alves Trigo, Rodrigo Cordon Isaac, André Breda Bauab Filho, Sabrina Furtunato de Oliveira, Maria Eduarda Almeida Cavalcanti, Tarcísio Fernando Honorio da Silva, Allycia Jamylle Nogueira de Mello, Paula Rafaela Nunes do Carmo, Lucas dos Santos Silva, Lucélia Barros Tenório, Bruna Michelly de Barros Canuto Pinheiro, Lara Amaral Santos Cunha

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