Keywords
How to Cite
Abstract
Psoriasis is a chronic, non-contagious, autoimmune inflammatory disease that affects approximately 2 to 5% of the world's population. Influenced by emotional, environmental and genetic factors, it manifests as reddish, scaly lesions, mainly in plaques on the skin. The disease involves epidermal hyperplasia and an inadequate immune response, with activated T lymphocytes and macrophages releasing cytokines such as TNF-α, which are fundamental in the inflammatory process. The pathophysiology includes changes in keratinocytes and the immune response, with involvement of cells such as keratinocytes and dendritic cells, resulting in conditions such as vulgaris, guttate, erythrodermic, inverse and palmoplantar psoriasis. Treatments include the use of emollients, vitamin D analogues, methotrexate and immunobiologicals, in addition to alternative therapies such as aloe vera, which has anti-inflammatory and healing properties, helping to reduce symptoms.
References
BELLAMY, L. et al. Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. BMJ, v.335, n.7627, p.974, 2007.
AMIM, M. et al. Psoriasis and Co-morbidity. Acta Dermato-Venereologica, v.100, n. 3, p.33, 2020.
Carneiro, S. Psoríase: mecanismos de doença e implicações terapêuticas, 2007
El-Dairi, M. et al. Optic nerve hypoplasia. In Handbook of Pediatric Retinal OCT and the Eye-Brain Connection. p. 285–287, 2019.
FERREIRA, I.I.B. et al. Plantas e produtos vegetais no trata-mento da psoríase. Dissertação (Mestrado Integrado em Ciências Farmacêuticas) -Universidade de Lisboa, Porto, Portugal, 2019.
LEBWOHL M. Psoriasis. Annals of Internal Medicine, v. 168, n.7, p.49-64, 2018.
LIMA, E.A. et al. Imunopatogênese da psoríase: revisando conceitos. Anais Brasileiros de Dermatologia, v.86, n.6, p.1151–1158, 2011.
MARQUES, P.P. et al. Qualidade de vida de pacientes com psoríase: avaliação do índice de incapacidade. Revista Arquivos Ciências da Saúde, São José do Rio Preto, v. 18, n. 2, p. 6-73, 2011.
OLIBONI, L. et al. Correlação entre a concentração sérica de interleucina-6 (IL-6) e biomarcadores de resistência insulínica em adultos jovens obesos. Clinical & Biomedical Research, v.36, n.3, p.148–155, 2016.
PARRA, S.G. et al. Psoriasis and Depression: The Role of Inflammation. Actas Dermo-Sifiliográficas, v.110, n.1, p. 12-19, 2019.
PINTO, G.M. et al. Normas de boa prática para o tratamento da psoríase em placas em idade não pediátrica com biológicos. Revista Científica da Ordem dos Médicos, São Paulo, v. 69, n. 2, p. 125-141, 2012.
SANCHEZ, A. P. G. Immunopathogenesis of psoriasis. Anais Brasileiros de Dermatologia, v.85, n.5, p.747–749, 2010.
TOKUYAMA, M. et al. New Treatment Addressing the Pathogenesis of Psoriasis, v.21, n.20, p.74-88, 2020.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2024 Raphael Siza de Oliveira e Oliveira, Thiago Silva Zanuto, Camila Melo de Freitas Oliveira, Helena Braule Pinto Simeão, Igor Henrique Correia Magalhaes, Isabela Abud de Andrade, Joana Bader Sadala Brandão, Júlia bobato Ramos de Almeida, Laura Souza de Jesus, Letícia Barroso Luniere, Luiza Fernanda Mendonça Nicolau, Mariana Belo de Almeida, Walace Silva Ataides, Natalia da Silva Ataide