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Abstract
As metástases cardíacas, apesar de raras, representam uma complicação crítica em pacientes com câncer avançado, frequentemente associadas a neoplasias de pulmão, mama e melanoma. Este artigo revisa de forma abrangente a incidência dessas metástases, os mecanismos biológicos subjacentes, as diversas apresentações clínicas, bem como os métodos diagnósticos e opções terapêuticas disponíveis. Devido à complexidade anatômica do coração e à diversidade dos tumores que podem acometê-lo, o manejo eficaz das metástases cardíacas exige uma abordagem multidisciplinar que envolve oncologistas, cardiologistas, radiologistas e cirurgiões. O prognóstico para esses pacientes é geralmente reservado, com uma sobrevida média limitada, enfatizando a necessidade de avanços contínuos na detecção precoce e no desenvolvimento de terapias mais eficazes. As perspectivas futuras incluem a personalização do tratamento com base em perfis moleculares dos tumores, a integração de novas terapias-alvo e imunoterapias, além da aplicação de tecnologias avançadas de imagem e biomarcadores circulantes para melhorar o monitoramento da progressão da doença e a resposta ao tratamento. A colaboração entre diferentes especialidades médicas e o estabelecimento de centros de excelência dedicados ao tratamento de tumores cardíacos são fundamentais para o aprimoramento dos cuidados e dos resultados clínicos.
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Copyright (c) 2024 Daniel Humming, Aline Reinert Dazzi, Giulia Wichoski Campiol, Juliana Tadeu Thomé, Vitor Roque Sauer, Maria Gabriela Companhoni, Maria Júlia Dacas Dacheux do Nascimento, Jessé Alves da Cunha, Jolmar Leonardo Penazzo Machado, Natally Gabrielly Martin Fernandes, Mohamad Jihad Omairi, Lara Novakowski Spigolon, Tuany Caroline Bernardi
