Neonatal Hypoglycemia: A literature review
DOI:
https://doi.org/10.36557/2674-8169.2024v6n8p4342-4357Keywords:
Clinical condition, Challenges, Neonatal hypoglycemiaAbstract
Introduction: Neonatal hypoglycemia (NH) is a common clinical condition in newborns where symptoms range from tremors and irritability to convulsions and lethargy. However, its early identification and management are significant clinical challenges in neonatology, as there is no established protocol for the adequate management of these conditions. The objective of the work aims to review and synthesize the most recent and relevant studies on neonatal hypoglycemia, including its diagnosis, treatment and short and long-term outcomes. Methodology: This is a literature review through the analysis of articles and guidelines that address the topic and objective of the study. The databases used were Scielo and Pubmed, using the descriptors “hypoglycemia” and “neonatal”. After applying the inclusion and exclusion criteria, 13 articles were separated for analysis. Results and Discussion: It was seen that the use of dextrose gel reduces the incidence of hypoglycemia and effectively improves glucose levels. The use of such substances is effective in momentary treatment, however, in the long term, no benefit of the substance to prevent complications of hypoglycemia has been identified. Furthermore, it was noticed that the use of MCG reduced the exposure of premature babies who needed intensive care to prolonged or severe episodes of hyper- or hypoglycemia. Conclusion: By studying the fundamental aspects of managing neonatal hypoglycemia, including diagnostic methods, therapeutic strategies and prognostic considerations, we can understand the challenges and evaluate the benefits of interventions when necessary, which can not only improve clinical outcomes, but also guide clinical practices. evidence-based strategies to mitigate the risks associated with this common condition in neonates.
Downloads
References
ANGELIKA, D., ETIKA, R., UTOMO, M. T., MIRHA, S., HANDAYANI, K. D., & UGRASENA, I. D. G. (2021). The glucose infusion rate of parenteral nutrition in the first week of life in preterm infants: an observational study. Italian Journal of Pediatrics, 47(1). Disponível em: <https://pubmed.ncbi.nlm.nih.gov/34736488/>. Acesso em __ de ____ 2024.
BEARDSALL, K., THOMSON, L., GUY, C., IGLESIAS-PLATAS, I., VAN WEISSENBRUCH, M. M., BOND, S., ALLISON, A., KIM, S., PETROU, S., PANTALEO, B., HOVORKA, R., & DUNGER, D. (2021). Real-time continuous glucose monitoring in preterm infants (REACT): an international, open-label, randomised controlled trial. Lancet Child & Adolescent Health, 5(4). Disponível em: <https://pubmed.ncbi.nlm.nih.gov/33577770/>. Acesso em __ de ____ 2024.
BEARDSALL, K., THOMSON, L., ELLERI, D., DUNGER, D. B., & HOVORKA, R. (2020). Feasibility of automated insulin delivery guided by continuous glucose monitoring in preterm infants. Archivos de Pediatría del Uruguay, 105(3). Disponível em: <https://pubmed.ncbi.nlm.nih.gov/31399480/>. Acesso em __ de ____ 2024.
Consenso Clínico “Hipoglicemia neonatal”. Secção de neonatologia spp.
DE LEON, Diva D. et al. 2023.
EDWARDS, T., ALSWEILER, J. M., CROWTHER, C. A., EDLIN, R., GAMBLE, G. D., HEGARTY, J. E., LIN, L., MCKINLAY, C. J. D., ROGERS, J. A., THOMPSON, B., WOULDES, T. A., & HARDING, J. E. (2022). Prophylactic Oral Dextrose Gel and Neurosensory Impairment at 2-Year Follow-up of Participants in the hPOD Randomized Trial. JAMA, 327(12). Disponível em: <https://pubmed.ncbi.nlm.nih.gov/35315885/>. Acesso em __ de ____ 2024.
EDWARDS, T., ALSWEILER, J. M., GAMBLE, G. D., GRIFFITH, R., Lin, L., MCKINLAY, C. J. D., ROGERS, J. A., THOMPSON, B., Wouldes, T. A., & HARDING, J. E. (2022). Neurocognitive outcomes at 2 years of age following neonatal hypoglycemia in a cohort of participants from the hPOD randomized trial. JAMA Network Open, 5(10). Disponível em: <https://pubmed.ncbi.nlm.nih.gov/36219444/>. Acesso em __ de ____ 2024.
HARDING, J. E., HEGARTY, J. E., CROWTHEr, C. A., EDLIN, R. P., GAMBLE, G. D., ALSWEILER, J. M., & Grupo de Estudo hPOD. (2021). Evaluation of oral dextrose gel for prevention of neonatal hypoglycemia (hPOD): A multicenter, double-blind randomized controlled trial. PLOS. Medicine, 18(1), e1003411.Disponível em: <https://pubmed.ncbi.nlm.nih.gov/33507929/>. Acesso em __ de ____ 2024.
LAING, D., WALSH, E., ALSWEILER, J. M., HANNING, S. M., MEYER, M. P., ARDERN, J., CUTFIELD, W. S., ROGERS, J., GAMBLE, G. D., CHASE, J. G., HARDING, J. E., & MCKINLAY, C. J. D. (2022). Oral diazoxide versus placebo for severe or recurrent neonatal hypoglycaemia: Neonatal Glucose Care Optimisation (NeoGluCO) study - a randomised controlled trial. BMJ Open, 12(8). Disponível em: <https://pubmed.ncbi.nlm.nih.gov/35977769/>. Acesso em __ de ____ 2024.
PARK, E. H. G., O’BRIEN, F., SEABROOK, F., & HIRST, J. E. (2021). Safe threshold of capillary blood glucose for predicting early future neonatal hypoglycaemia in babies born to mothers with gestational diabetes mellitus, an observational, retrospective cohort study. BMC Pregnancy and Childbirth, 21(1). Disponível em: <https://pubmed.ncbi.nlm.nih.gov/34243753/>. Acesso em __ de ____ 2024.
Protocolo Clínico #1 ABM: Diretrizes de Monitoramento da Glicemia e Tratamento de Hipoglicemia em Recém-Nascidos a Termo e Prematuros Tardios, revisado 2021. Nancy E. Wight, MD, IBCLC, FABM, FAAP; e Academia de Medicina da Amamentação.
SOBRERO, H., PIZZORNO, N., ALONSO, C., CAILLABET, A., DE LOS SANTOS, J., DENDI, Á., MORAES, M. (2023). Prevención de hipoglicemia neonatal en recién nacidos con factores de riesgo mediante la administración bucal de una dosis de gel de dextrosa al 40%: ensayo clínico aleatorizado. Archivos de Pediatría del Uruguay, 94(2), 7. Disponível em: <http://www.scielo.edu.uy/scielo.php?script=sci_arttext&pid=S1688-12492023000301214>. Acesso em __ de ____ 2024.
ST CLAIR, S. L., DAI, D. W. T., HARRIS, D. L., GAMBLE, G. D., MCKINLAY, C. J. D., NIVINS, S., SHAH, R. K., THOMPSON, B., & HARDING, J. E. (2023). Mid-Childhood Outcomes after Dextrose Gel Treatment of Neonatal Hypoglycaemia: Follow-Up of the Sugar Babies Randomized Trial. Neonatology, 120(1). Disponível em: <https://pubmed.ncbi.nlm.nih.gov/36516806/>. Acesso em __ de ____ 2024.
Suíça. KALLEM et al., 2017; SHARMA et al., 2017; Thompson-Branch & Havranek, 2017.
SURACHAIDUNGTAVIL, S., CHANVORACHOTE, P., & SUKSUMEK, N. (2020). A Randomized Control Trial of Oral Sucrose Solution for Prevention of Hypoglycemia in High Risk Infants. In Vivo, 34(3), 1493-1497. Disponível em: <https://iv.iiarjournals.org/content/34/3/1493 and https://pubmed.ncbi.nlm.nih.gov/32354952/>. Acesso em __ de ____ 2024.
THOMSON, L., ELLERI, D., BOND, S., HOWLETT, J., DUNGER, D. B., & BEARDSALL, K. (2019). Targeting glucose control in preterm infants: pilot studies of continuous glucose monitoring. Archivos de Pediatría del Uruguay, 104(4). Disponível em: <https://pubmed.ncbi.nlm.nih.gov/30232094/>. Acesso em __ de ____ 2024.
2019 - 2024. Associação Bahiana de Medicina.
SOCIEDADEBRASILEIRA DE PEDIATRIA (SBP). Diretrizes SBP –Hipoglicemia no Período Neonatal. 2014. Disponível em: http://www.sbp.com.br/fileadmin/ user_upload/2015/02/diretrizessbp-hipoglicemia2014.pdf. Data de acesso: 05/11/2018.
KALLEM, V. R.; PANDITA, A.; GUPTA, G. Hypoglycemia: When to Treat? Clinical medicine insights. Pediatrics, v.11, p. 1-9, 2017
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Letícia Silva Viana, Maria Luísa Barreto Paiva, Ana Maria Ribeiro Fonseca, Júlia Viana Umbelino, Lhais Santos da Silva, rodrigo Pessoa Leite, Rafael Joseph Macedo Paradis, Rafael Cruz Mariz, Augusto Moroni Brito Paz, Isabella Pereira Barbosa, Karen Matos Costa, Débora Cristina Fontes Leite

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors are copyright holders under a CCBY 4.0 license.



