EMERGING CONCERN: EPIDEMIOLOGY, DIAGNOSIS, AND CONTROL OF OROPOUCHE FEVER
DOI:
https://doi.org/10.36557/2674-8169.2024v6n8p2758-2770Keywords:
Epidemiology, Oropouche fever, Clinical Diagnosis, Biological Vector Control.Abstract
Oropouche Fever, caused by an arbovirus, has stood out as one of the main public health problems in the tropical regions of Latin America, especially in the Amazon region of Brazil. This emerging virus, which is becoming increasingly prevalent, recognized as one of the most important etiological agents of fever in the region, with a significant spread to other regions. Rapid transmission in urban areas and the lack of accurate diagnostics and effective vaccines underscore the need for a deeper understanding of the disease. This study aims to perform an integrative review on the epidemiology, diagnosis, and control of Oropouche fever, highlighting the most recent evidence and identifying gaps in current knowledge. An integrative literature review was conducted, using PRISMA guidelines, to identify and analyze studies published between 2019 and 2024 on Oropouche virus. The PubMed, Scopus, SciELO and LILACS databases were used in the search for relevant scientific articles, using key terms such as "Oropouche Fever", "Epidemiology", "Clinical Diagnosis", "Biological Control of Vectors". The results show that the transmission of OROV involves multiple vectors, with significant challenges in diagnosis due to the overlap of symptoms with other arboviruses. In addition, the lack of vaccines and specific treatments highlights the urgent need for new interventions. In addition, vector control measures proved to be insufficient, reflecting the high vulnerability of the affected populations. It is concluded that, in order to effectively control Oropouche fever, continuous efforts in research are necessary, as well as the development of public health policies aimed at the prevention and management of the disease, especially in endemic regions.
Downloads
References
ANDERSON, C. R.; SPENCE, L.; DOWNS, W. G.; AITKEN, T. H. Oropouche virus: a new human disease agent from Trinidad, West Indies. American Journal of Tropical Medicine and Hygiene, v. 10, p. 574-578, 1961.
BARRETT, A. D. T. Current status of flavivirus vaccines. Annals of the New York Academy of Sciences, v. 1479, n. 1, p. 35-44, 2021.
BONIFAY, T. et al. Review on main arboviruses circulating on French Guiana, an ultra-peripheric European region in South America. Viruses, v. 15, p. 1268, 2023. Disponível em: <https://doi.org/10.3390/v15061268>.
BRISE, T. et al. Viruses of the family Bunyaviridae: are all available isolates reassortants? Virology, v. 446, p. 207–216, 2013.
CASTILLETTI, C. et al. Oropouche fever cases diagnosed in Italy in two epidemiologically non-related travellers from Cuba, late May to early June 2024. Eurosurveillance, v. 29, n. 26, 27 jun. 2024.
FERREIRA, E. Oropouche virus – The “Newest” invisible public enemy?. Bioorganic & Medicinal Chemistry, v. 109, p. 117797–117797, 1 jul. 2024.
FEITOZA, L. H. M. et al. Influence of meteorological and seasonal parameters on the activity of Culicoides paraensis (Diptera: Ceratopogonidae), an annoying anthropophilic biting midge and putative vector of Oropouche Virus in Rondônia, Brazilian Amazon. Acta Tropica, v. 243, p. 106928, 2023. Disponível em: <https://doi.org/10.1016/j.actatropica.2023.106928>.
FILES, M. A. et al. Baseline mapping of Oropouche virology, epidemiology, therapeutics, and vaccine research and development. NPJ Vaccines, v. 7, p. 38, 2022. Disponível em: <https://doi.org/10.1038/s41541-022-00456-2>.
FIGUEIREDO, L. T. M. Emergent arboviruses in Brazil. Revista da Sociedade Brasileira de Medicina Tropical, v. 40, p. 224–229, 2007.
GANJIAN, N. et al. Arboviral infections of the central nervous system in Latin America. Journal of Neurological Sciences, v. 396, p. 1-11, 2019.
GUTIERREZ, B. et al. Evolutionary dynamics of Oropouche virus in South America. Journal of Virology, v. 94, e01127-19, 2020. Disponível em: <https://doi.org/10.1128/jvi.01127-19>.
HOCH, A. L. et al. Oropouche virus transmission in the Amazon: a case study. American Journal of Tropical Medicine and Hygiene, v. 36, n. 2, p. 238-242, 1987.
KUHN, J. H. et al. Annual (2023) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota). Journal of General Virology, v. 104, p. 001864, 2023. Disponível em: <https://doi.org/10.1099/jgv.0.001864>.
LASH, R. R. et al. COVID-19 and tuberculosis trends in the USA. International Journal of Tuberculosis and Lung Disease, v. 25, n. 4, p. 317-323, 2021.
LOURENÇO, R. O.; FAILLOUX, A. B. High risk for chikungunya virus to initiate an enzootic sylvatic cycle in the tropical Americas. PLoS Neglected Tropical Diseases, v. 11, n. 6, 2017.
PINHEIRO, F. P. et al. Oropouche virus. I. A review of clinical, epidemiological, and ecological findings. *American Journal of Tropical Medicine and Hygiene*, v. 30, p. 149–160, 1981.
MARTINS-FILHO, P. R. et al. The underdiagnosed threat of oropouche fever amidst dengue epidemics in Brazil. The Lancet regional health. Americas, v. 32, p. 100718–100718, 1 abr. 2024.
SAH, R. et al. Oropouche fever outbreak in Brazil: an emerging concern in Latin America. The Lancet Microbe, 1 jul. 2024.
SCACHETTI, G. C. et al. Reemergence of Oropouche virus between 2023 and 2024 in Brazil. medRxiv (Cold Spring Harbor Laboratory), 30 jul. 2024.
TRAVASSOS DA ROSA, J. F. et al. Oropouche virus: clinical, epidemiological, and molecular aspects of a neglected Orthobunyavirus. American Journal of Tropical Medicine and Hygiene, v. 96, p. 1019–1030, 2017. Disponível em: <https://doi.org/10.4269/ajtmh.16-0672>.
VASCONCELOS, H. B. et al. Molecular Epidemiology of Oropouche Virus, Brazil. Emerging Infectious Diseases, v. 17, n. 5, p. 800–806, maio 2011.
VALERO, N. Oropouche Virus: what is it and how it is transmitted? Investigación Clínica, v. 58, p. 1–2, 2017.
WESSELMANN, K. M. et al. Emergence of Oropouche fever in Latin America: a narrative review. The Lancet Infectious Diseases, p. S1473-3099(23)007405, 25 jan. 2024.
ZHANG, Y. et al. Oropouche virus: A neglected global arboviral threat. Virus Research, v. 341, p. 199318, 1 mar. 2024.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Carine Vitoria Lemes da Silva, Maria Emília Barbosa de Oliveira, Gleison Lucas Santos do Nascimento, Liniker Andrade Oliveira, Vinícius Andrade Oliveira, Lara Samanta Barbosa RIbeiro, Cecília Maria Rodrigues de França, Alexandre Lopes dos Santos, Daniel Rodrigues Furtado, Gabriela Brandão Silva de Carvalho Lopes, Cynthia Rayelle de Arruda Porto, Mariana Carvalho Moreira, Bruno Bibiano de Oliveira, Rodrigo Daniel Zanoni

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors are copyright holders under a CCBY 4.0 license.



