Management of Acute Liver Failure in Patients with Chronic Viral Hepatitis

Authors

  • Marcelo Fontes da Silva Universidade Federal de Mato Grosso do Sul
  • José Amarildo Avanci Júnior Universidade Federal de Mato Grosso do Sul
  • Melissa Garcia Silva Saut Universidade Anhanguera-UNIDERP
  • Erica Prevital Nery Universidade Anhanguera-UNIDERP
  • Sarah Flores Serpa Universidade Federal de Mato Grosso do Sul
  • Maria Isabella Calvento Rodrigues Universidade Anhanguera-UNIDERP
  • Beatriz Corrêa Lyrio Universidade Estadual de Mato Grosso do Sul
  • Giulia Comarella Universidade Anhanguera-UNIDERP
  • Lucas Oliveira Morais Universidade Estadual de Mato Grosso do Sul
  • Álvaro Nantes Vieira Gastaldi Universidade Anhanguera-UNIDERP
  • Josué Gabriel da Costa Afya Faculdade de Ciências Médicas da Paraíba
  • Carolina Mazutti Michel Universidade Anhanguera-UNIDERP

DOI:

https://doi.org/10.36557/2674-8169.2024v6n8p2589-2605

Keywords:

Antivirals, Hepatic Encephalopathy, Hepatic Fibrosis

Abstract

This article reviews the management of acute liver failure (ALF) in patients with chronic viral hepatitis, a severe condition that results in high mortality and requires prompt and effective interventions. Chronic viral hepatitis, particularly those caused by hepatitis B (HBV) and hepatitis C (HCV) viruses, can progress to ALF due to viral reactivations, superinfections, or factors such as alcohol consumption and the use of hepatotoxic drugs. The aim of this study was to review the existing literature to identify effective strategies for the prevention and clinical management of ALF in patients with chronic viral hepatitis. The methodology involved an integrative review of articles published between 2013 and 2023, using databases such as PubMed, SciELO, and LILACS, with strict inclusion criteria to ensure the relevance of the studies analyzed. The results indicate that ALF in these patients is often precipitated by a combination of factors, including viral reactivations and exposure to hepatotoxic agents. Effective management of ALF requires suppression of viral replication through the use of antivirals, intensive care support, and, in severe cases, emergency liver transplantation. Liver transplantation has been shown to be the most effective intervention for critically ill patients, offering significantly higher long-term survival rates. However, prevention remains the most effective focus, emphasizing regular monitoring of liver function, strict adherence to antiviral therapy, and patient education on the risks of hepatotoxic substances. It is concluded that while liver transplantation is crucial for saving lives in advanced cases, preventive strategies and early interventions are essential to reduce the incidence of ALF and improve clinical outcomes in patients with chronic viral hepatitis.

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References

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Published

2024-08-18

How to Cite

Silva , M. F. da, Júnior, J. A. A., Saut, M. G. S., Nery, E. P., Serpa , S. F., Rodrigues , M. I. C., Lyrio, B. C., Comarella , G., Morais, L. O., Gastaldi , Álvaro N. V., Costa, J. G. da, & Michel , C. M. (2024). Management of Acute Liver Failure in Patients with Chronic Viral Hepatitis. Brazilian Journal of Implantology and Health Sciences, 6(8), 2589–2605. https://doi.org/10.36557/2674-8169.2024v6n8p2589-2605

Issue

Vol. 6 No. 8 (2024): BJIHS QUALIS B3 - FATOR DE IMPACTO SJIF 5.807

Section

Literature Review

License

Copyright (c) 2024 Marcelo Fontes da Silva , José Amarildo Avanci Júnior, Melissa Garcia Silva Saut, Erica Prevital Nery, Sarah Flores Serpa , Maria Isabella Calvento Rodrigues , Beatriz Corrêa Lyrio, Giulia Comarella , Lucas Oliveira Morais, Álvaro Nantes Vieira Gastaldi , Josué Gabriel da Costa, Carolina Mazutti Michel

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors are copyright holders under a CCBY 4.0 license.