POLYPHARMACY AND RISK OF INTOXICATION: ANALYSIS OF THE USE OF PSYCHOTROPIC DRUGS POLIFARMACIA Y RIESGO DE INTOXICACIÓN: ANÁLISIS DEL USO DE PSICOFÁRMACOS
DOI:
https://doi.org/10.36557/2674-8169.2024v6n8p1907-1918Keywords:
Polypharmacy, poisoning, psychotropic drugs.Abstract
Introduction: Every day the number of people who need treatment with psychotropic drugs due to mental health problems grows. Thus, an increase in the number of medications per individual is evidenced, causing psychotropic polypharmacy. There are several benefits, however, there are several risks. Among them, the risk of intoxication stands out. Thus, inquiring about the polypharmacy of psychotropic drugs and the risk of intoxication, the study was carried out. Objective: to analyze through the current literature the risk of intoxication derived from psychotropic polypharmacy. Method: systematic literature review, through a search in the Latin American and Caribbean Health Sciences, Google Scholar and Scientific Electronic Library Online databases, using the descriptors: Polypharmacy; Psychotropics; Intoxication; Poisoning. Through this, six articles were selected that made up the inclusion and exclusion criteria of the present study. Result: The studies list that psychotropic polypharmacy is common, however, combinations without scientific evidence, prescription without dialogue with other professionals and inappropriate, can cause several risks. Thus, the risk of intoxication in patients with polypharmacy is great and can have catastrophic effects on the individual's
health, even leading to death. Conclusion: It is evident that the dissemination of knowledge to the population about polypharmacy and the risk of intoxication, in addition to improving communication between professionals, observation of the patient in a holistic and integral way and dissemination of knowledge with evidence is essential to minimize wrong combinations, incorrect prescriptions, unnecessary polypharmacy and the risks to patients of intoxication and other consequences.
Downloads
References
Brett J, Pearson SA, Daniels B, Wylie CE, Buckley NA. A cross sectional study of psychotropic medicine use in Australia in 2018: A focus on polypharmacy. Br J Clin Pharmacol. 2020; v.87, p.1369-1377. doi: https://doi.org/10.1111/bcp.14527
Mellor R, Khoo A, Saunders-Dow E, Raguz E, Taing MW, Hanjani LS, Freeman C, Crawford D. Polypharmacy in Australian Veterans with Post-traumatic Stress Disorder upon Admission to a Mental Health Facility: A Retrospective Chart Review. Drugs Real World Outcomes. 2022 May 17. doi: 10.1007/s40801-022-00298-3.
Ruiz-Goikoetxea M, Cortese S, Magallón S. Risk of poisoning in children and adolescents with ADHD: a systematic review and meta-analysis. Sci Rep, 7584, 2018. doi: https://doi.org/10.1038/s41598-018-25893-9
Rhee TG, Rosenheck RA. Psychotropic polypharmacy reconsidered: Between-class polypharmacy in the context of multimorbidity in the treatment of depressive disorders. J Affect Disord. 2019 Jun 1;252:450-457. doi: 10.1016/j.jad.2019.04.018
Rasimas JJ, Liebelt EL. Adverse Effects and Toxicity of the Atypical Antipsychotics: What is Important for the Pediatric Emergency Medicine Practitioner. Clin Pediatr Emerg Med. 2012 Dec 1;13(4):300-310. doi: 10.1016/j.cpem.2012.09.005.
Brett J, Daniels B, Karanges EA, Buckley NA, Schneider C, Nassir A, McLachlan AJ, Pearson SA. Psychotropic polypharmacy in Australia, 2006 to 2015: a descriptive cohort study. Br J Clin Pharmacol. 2017 Nov;83(11):2581-2588. doi: 10.1111/bcp.13369.
Hoel RW, Giddings Connolly RM, Takahashi PY. Polypharmacy Management in Older Patients. Mayo Clin Proc. 2021 Jan;96(1):242-256. doi: 10.1016/j.mayocp.2020.06.012.
Reuss CF, Hasselstrøm JB, Linnet K, Christoffersen DJ, Leth PM, Boel LWT, Banner J. Increased risk of fatal intoxication and polypharmacy among psychiatric patients at death. J Forensic Sci. 2021 Jan;66(1):255-264. doi: 10.1111/1556- 4029.14586.
Bohnert AS, Ilgen MA, Galea S, McCarthy JF, Blow FC. Accidental poisoning mortality among patients in the Department of Veterans Affairs Health System. Med Care. 2011 Apr;49(4):393-6. doi: 10.1097/MLR.0b013e318202aa27.
Mainoli B, Gonçalves N, Ferreira JJ, Mégarbane B. Potential drug-drug interactions in acute poisonings managed in the intensive care unit: Occurrence, risk factors and relationship to patient severity on admission. Basic Clin Pharmacol Toxicol. 2022 Feb;130(2):337-345. doi: 10.1111/bcpt.13698.
Aoyama, K., Tachi, T., Kubo, S., Koyama, A., Watanabe, M., Aoyama, S., ... & Teramachi, H. (2024). Probable effects of polypharmacy and equivalent doses of psychotropic drugs on prevalence of adverse drug events among psychiatric inpatients in a general hospital in Japan. Human Psychopharmacology: Clinical and Experimental, e2890.
Palsøe, M. K., Hansen, C. J., Torp-Pedersen, C., Winkel, B. G., Linnet, K., Tfelt-Hansen, J., & Banner, J. (2024). Proarrhythmic drugs, drug levels, and polypharmacy in victims of sudden arrhythmic death syndrome: An autopsy-based study from Denmark. Heart Rhythm.
Lunghi, C., Rochette, L., Massamba, V., Tardif, I., Ouali, A., & Sirois, C. (2023). Psychiatric and non-psychiatric polypharmacy among older adults with schizophrenia: trends from a population-based study between 2000 and 2016. Frontiers in Pharmacology, 14, 1080073.
Truedson, P., Ott, M., Wahlström, L., Lundqvist, R., Maripuu, M., Lindmark, K., ... & Werneke, U. (2024). Serious adverse drug events associated with psychotropic treatment of bipolar or schizoaffective disorder: a 17-year follow-up on the LiSIE retrospective cohort study. Frontiers in Psychiatry, 15, 1358461.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Lara Vasconcelos Normando, Luísa de Souza Maurique, Rafael Martins Gomes , Aristone José Pacheco Marinho , Vitor Hugo Gomes Araújo , Gabriele Winter Santana, Isabella Scalabrini Ferrari , Isabella de Lara Aires Reis , José Carlos Saldanha Junior
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors are copyright holders under a CCBY 4.0 license.
