UNDERSTANDING CHAGAS DISEASE AND ITS HEMODYNAMIC REPERCUSSIONS: AN INTEGRATIVE REVIEW
DOI:
https://doi.org/10.36557/2674-8169.2024v6n8p813-825Keywords:
Doença de Chagas, Repercussões, Hemodinâmicas.Abstract
Introduction: Chagas disease, also known as American trypanosomiasis, is a neglected tropical disease caused by the protozoan Trypanosoma cruzi. It is primarily transmitted through the feces of triatomine insects, known as kissing bugs, but can also be acquired through blood transfusions, organ transplants, consumption of contaminated food, and congenital transmission.
Methodology: To conduct this integrative review on understanding Chagas disease and its hemodynamic repercussions, a systematic methodology was adopted aimed at obtaining and analyzing relevant and rigorous studies. This process included the definition of inclusion and exclusion criteria, the temporal delimitation of the publications to be considered, the selection of the databases to be consulted, and a detailed description of the types of studies included.
Results and Discussion: Chagas disease, scientifically known as American trypanosomiasis, is a neglected tropical disease that affects millions of people primarily in Latin America, although cases have been reported in other regions due to migration and globalization. Caused by the protozoan Trypanosoma cruzi, this disease has triatomine insects, also called kissing bugs, as its main route of infection. However, other modes of transmission include blood transfusions, organ transplants, consumption of contaminated food, and congenital transmission. The complexity and diversity of transmission forms make Chagas disease a significant challenge for global public health.
Conclusion: In conclusion, Chagas disease and its hemodynamic repercussions represent a significant public health challenge, particularly in the endemic regions of Latin America. Chronic Chagas cardiomyopathy, with its complications such as myocarditis, fibrosis, ventricular dilation, heart failure, and arrhythmias, has a profound impact on the health of affected individuals.
Downloads
References
Lima MM, Costa VM da, Palmeira SL, Castro APB de. Estratificação de territórios prioritários para vigilância da doença de Chagas crônica: análise multicritério para tomada de decisão em saúde. Cad Saúde Pública. 2021;37(6):e00175920. https://doi.org/10.1590/0102-311X00175920
Bruneto EG, Fernandes-Silva MM, Toledo-Cornell C, Martins S, Ferreira JMB, Corrêa VR, et al Case-fatality From Orally-transmitted Acute Chagas Disease: A Systematic Review and Meta-analysis. Clin Infect Dis. 2021;72(6):1084–92. https://doi.org/10.1093/cid/ciaa1148
Freitas VLT de, Esper HR, Nakanishi ES, Piotto MR, Assy JGPL, Berreta OCP, et al Suspected vertical transmission of Chagas disease caused by DTU TcIV in an infection probably transmitted orally, during an outbreak in the Brazilian Amazon. Rev Inst Med Trop São Paulo. 2021;63:e48. https://doi.org/10.1590/S1678-9946202163048
Martins-Melo FR, Ramos AN, Alencar CH, Heukelbach J. Prevalence of Chagas disease in Brazil: A systematic review and meta-analysis. Acta Trop. 2014;130:167–74. https://doi.org/10.1016/j.actatropica.2013.10.002
Munn Z, Moola S, Riitano D, Lisy K. The development of a critical appraisal tool for use in systematic reviews addressing questions of prevalence. Int J Health Policy Manag. 2014;3(3):123–8. https://doi.org/10.15171/ijhpm.2014.71
Nobre T, Fonseca S, Medeiros R, Hecht M, Hagström L, Fernandes MR, et al. Seroprevalence of Trypanosoma cruzi in pregnant women in Midwest Brazil: an evaluation of congenital transmission. Rev Inst Med Trop São Paulo. 2021;63:e8. https://doi.org/10.1590/S1678-9946202163008
Chadalawada S, Sillau S, Archuleta S, Mundo W, Bandali M, Parra-Henao G, et al. Risk of Chronic Cardiomyopathy Among Patients With the Acute Phase or Indeterminate Form of Chagas Disease: A Systematic Review and Meta-analysis. JAMA Netw Open. 2020;3(8):e2015072. https://doi.org/10.1001/jamanetworkopen.2020.15072
Carvalho EOC de, Rosa JA da, Carvalho AA de, Chaves HCO, Souza EA de, Ostermayer AL, et al Study on Chagas disease occurrence in the municipality of Monte Negro, State of Rondônia, Brazilian Amazon. Rev Soc Bras Med Trop. 2011;44(6):703–7. https://doi.org/10.1590/s0037-86822011000600010
Santos JP, da Silva R, Ricardo-Silva AH, Verly T, Britto C, Evangelista BBC, et al Assessing the entomo-epidemiological situation of Chagas disease in rural communities in the state of Piauí, Brazilian semi-arid region. Trans R Soc Trop Med Hyg. 2020;114(11):820–9. https://doi.org/10.1093/trstmh/traa070
Lima MM, Sarquis O, Oliveira TG de, Gomes TF, Coutinho C, Daflon-Teixeira NF, et al Investigation of Chagas disease in four periurban areas in northeastern Brazil: epidemiologic survey in man, vectors, non-human hosts and reservoirs. Trans R Soc Trop Med Hyg. 2012;106(3):143–9. https://doi.org/10.1016/j.trstmh.2011.10.013»
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Eliab Batista Barros, Nayane Mayse Barbosa Silva , Sophya Bezerra Silva Rocha, Victor Gustavo Amorim Silva , André Alves da Silva Freitas, Evellyn de Cássia Martins Rodrigues , Vanessa Maria Gonçalves de Souza , Flávia Garcia de Aquino, Laís Ferreira Silva , Thiago Dutra Mendonça
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors are copyright holders under a CCBY 4.0 license.
