Abstract
Mielomeningocele, a severe form of open spina bifida, is a congenital malformation of the central nervous system. Characterized by the exposure of the spinal cord and meninges due to a defect in neural tube closure during fetal development, the condition presents various neurological and medical complications throughout life. Treatment includes early closure of the defect to prevent infections and further damage to the spinal cord, along with a multidisciplinary approach to managing complications such as hydrocephalus, urological dysfunction, and musculoskeletal issues. Advances such as fetal surgery offer new perspectives, though they require further studies to validate their broad effectiveness. Folic acid supplementation is crucial in spina bifida prevention, underscoring the importance of maternal health. Economic and ethical considerations highlight the need for robust health policies to support these complex interventions.
References
ALNAAMI, I.; ALAYAD, E. Review on myelomeningocele management and its current status in Saudi Arabia. Neurosciences, v. 24, n. 1, p. 5–10, 1 jan. 2019.
ARAUJO JÚNIOR, E. et al. Procedure-related complications of openvsendoscopic fetal surgery for treatment of spina bifida in an era of intrauterine myelomeningocele repair: systematic review and meta-analysis. Ultrasound in Obstetrics & Gynecology, v. 48, n. 2, p. 151–160, ago. 2016.
BAGHDADI, T. et al. Surgical Management of Hip Problems in Myelomeningocele: A Review Article. Archives of Bone and Joint Surgery, v. 4, n. 3, p. 197–203, 1 jun. 2016.
BRASIL. Lei Nº 12.853. Brasília: 14 de agosto de 2013. COPP, A. J. et al. Spina bifida. Nature Reviews Disease Primers, v. 1, n. 1, p. 15007, 30 abr. 2015.
DANZER, E. et al. Fetal surgical intervention for myelomeningocele: lessons learned, outcomes, and future implications. Developmental Medicine & Child Neurology, v. 62, n. 4, p. 417–425, 16 dez. 2019.
HOXHA, M. et al. Pharmacoeconomic Evaluation of Costs of Myelomeningocele and Meningocele Treatment and Screening. ClinicoEconomics and Outcomes Research: CEOR, v. 16, p. 69–80, 9 fev. 2024.
MELLER, C. et al. Update on prenatal diagnosis and fetal surgery for myelomeningocele. Archivos Argentinos de Pediatria, v. 119, n. 3, 1 jun. 2021.
PHILLIPS, L. A.; BURTON, J. M.; EVANS, S. H. Spina Bifida Management. Current problems in pediatric and adolescent health care, v. 47, n. 7, p. 173–177, 2017.
SAHNI, M.; ALSALEEM, M.; OHRI, A. Meningomyelocele. Disponível em: <https://www.ncbi.nlm.nih.gov/books/NBK536959/>.
VOLOCHOVIČ, J. et al. Intrauterine fetoscopic closure of myelomeningocele: Clinical case and literature review. Taiwanese Journal of Obstetrics and Gynecology, v. 60, n. 4, p. 766–770, jul. 2021. YAMASHIRO, K. J.;
GALGANSKI, L. A.; HIROSE, S. Fetal myelomeningocele repair. Seminars in Pediatric Surgery, v. 28, n. 4, p. 150823, ago. 2019.

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Copyright (c) 2024 Leonardo Pereira Levada, Ingrid Lobo Ferreira, Mariana Faria Mendes, Alexandre Henrique Chies Filho, William Matheus Pongitory Cavalcante, Lucas de Oliveira Castelo, Emily Vitória Costa Bentes Rodrigues, Enrico da Silva Rampasio, João Gabriel Olivoto Salgueiro, Júlia Gomes de Oliveira, Ana Flávia Duque Nunes, Giovanna Bruna Real Antonio, Maria Manuela Cecchini Souza Damasceno Nogueira, Rafael Pinto Martins de Oliveira, Juliano de Freitas Jardim, Camila Trindade de Abreu