Abstract
This article aims to scan the current medical literature on DRESS syndrome. Integrative review in the BVS, LILACS, SciELO, PubMed database of works published between 2019 and 2023, combining the descriptors "DRESS syndrome", "diagnosis" and "treatment" with the Boolean descriptor "AND". DRESS syndrome is a pharmacodermia that can be caused by several medications (mainly anticonvulsants), identified as an antigen by the body, triggering hypersensitivity of T lymphocytes. The time between exposure and reaction varies from two to six weeks. It is concluded that DRESS Syndrome is a severe drug-induced hypersensitivity reaction with high morbidity and mortality. This review demonstrates the importance of early diagnosis and medication suspension. More studies are still needed to reach a consensus on diagnosis and treatment.
References
BECK, J. DRESS syndrome: More than just a rash. JAAPA: official journal of the American Academy of Physician Assistants, v. 37, n. 3, p. 1–4, 1 mar. 2024.
BEHERA, S. K. et al. DRESS syndrome: a detailed insight. Hospital Practice (1995), v. 46, n. 3, p. 152–162, 1 ago. 2018.
BRUM, C.N. et al. Revisão narrativa de literatura: aspectos conceituais e metodológicos na construção do conhecimento da enfermagem. In: LACERDA, M.R.; COSTENARO, R.G.S. (Orgs). Metodologias da pesquisa para a enfermagem e saúde: da teoria à prática. Porto Alegre: Moriá, 2015.
CALLE, A. et al. DRESS syndrome: A literature review and treatment algorithm. World Allergy Organization Journal, v. 16, n. 3, p. 100673–100673, 1 mar. 2023.
CARDONES, A. R. Drug reaction, eosinophilia, and systemic symptoms (DRESS) syndrome. Clinics in Dermatology, jun. 2020.
CASTELLAZZI, M. L. et al. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome in two young children: the importance of an early diagnosis. Italian Journal of Pediatrics, v. 44, n. 1, p. 93, 15 ago. 2018.
CORNELI, H. M. DRESS Syndrome. Pediatric Emergency Care, v. 33, n. 7, p. 499–502, jul. 2017.
JAIN, P. et al. DRESS Syndrome. The Journal of the Association of Physicians of India, v. 67, n. 4, p. 87–88, 1 abr. 2019.
CUESTAS, D. et al. Drug reaction with eosinophilia and systemic symptoms (DRESS) and multiple organ dysfunction syndrome (MODS): one more reason for a new effective treatment against leishmaniasis. International Journal of Dermatology, v. 57, n. 11, p. 1304–1313, 1 nov. 2018.
ISAACS, M.; CARDONES, A. R.; RAHNAMA-MOGHADAM, S. DRESS syndrome: clinical myths and pearls. Cutis, v. 102, n. 5, p. 322–326, 1 nov. 2018.
MANIERI, E. et al. Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in childhood: a narrative review. Frontiers in Medicine, v. 10, 28 jul. 2023.
SCHUNKERT, E. M.; DIVITO, S. J. Updates and Insights in the Diagnosis and Management of DRESS Syndrome. Current Dermatology Reports, 9 nov. 2021.
SHARMA, A. N. et al. Characterizing DRESS syndrome recurrence: a systematic review. Archives of Dermatological Research, v. 314, n. 8, p. 721–728, 1 out. 2022.
SHIOHARA, T.; KANO, Y. Drug reaction with eosinophilia and systemic symptoms (DRESS): incidence, pathogenesis and management. Expert Opinion on Drug Safety, p. 1–9, 21 dez. 2016.
SOARES, S. G.; MENDES, M. H.; PINTO-LOPES, P. DRESS syndrome: an unlikely diagnosis with an unlikely cause. Porto Biomedical Journal, v. 7, n. 5, p. e154, set. 2022.
TOMANI, M. et al. Complicated Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome History in a 14-Year-Old. American Journal of Case Reports, v. 22, 18 jan. 2021.
WOLFSON, A. R. et al. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Identified in the Electronic Health Record Allergy Module. The Journal of Allergy and Clinical Immunology: In Practice, v. 7, n. 2, p. 633–640, 1 fev. 2019.

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Copyright (c) 2024 Ana Cláudia de Moraes Bastos Castilho Rivas , Jefferson Matheus Nunes Dutra , Patrícia Suenne Souza Araújo, Maria Cristina Alves de Queiroz Campos, Maurício Nascimento Ribeiro Filho , Julia Hasegawa, Thais Pereira Gomes Franco , Jaqueline Giselle Farias Fernandes, Leonardo Cortes de Aguiar Franco, Marcos Antônio de Aguiar Franco Júnior , Talita Barbosa Gomes, Rodrigo Daniel Zanoni