ASSOCIATION BETWEEN ENDOMETRIOSIS AND OXIDATIVE STRESS: A LITERATURE REVIEW
DOI:
https://doi.org/10.36557/2674-8169.2024v6n5p1096-1115Keywords:
Endometriosis, Oxidative stress, Free radicals, InflammationAbstract
The present article aims to review the literature regarding the relationship between endometriosis, oxidative stress and inflammation, aiming to list the possible mechanisms influenced by OS and its relationship with the prevalence of this pathology. This is a systematic literature review, which seeks, based on the current bibliography, conclusions for the guiding question. Thus, scientific studies were selected on the PubMed and VHL platforms, using the following search strategies: “endometriosis AND free radicals”, “inflammation AND oxidative stress AND endometriosis”, “oxidative stress AND endometriosis”. Nine articles were selected and analyzed to support the work from different points of view. After the review, it was evidenced that oxidative stress, associated with the local and systemic inflammatory response, favors the adhesion of endometrial cells in the peritoneal cavity and the consequent emergence of endometriotic lesions and all related symptoms. Therefore, the relationship between the pathogenesis of endometriosis and the homeostatic dysfunction caused by OS becomes evident. However, more studies are needed, especially of a quantitative nature, to determine a classification, based on scientific evidence, for the use of oxidative biomarkers and the respective pathways that are affected by an increase in them.
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Copyright (c) 2024 Johnatan da Conceição Bezerra dos Santos, Nathalya Bezerra Brasil, Icaro Bruno Azevedo Rodrigues, Liz Ferrari Cedrim, Lara Vasconcelos de Melo Amorim, Maria Fernanda Calheiros Magalhães Sampaio, Isabelli Maria Sarmento Lopes, Vinícius Albuquerque, Marcelo Danilo Damaso Lisboa Costa, Mariana Guerra de Holanda Barbosa, Priscila Clark Bertho Clark, Raquel dos Santos Coruripe Rocha
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