SARS-COV-2: IMMUNE RESPONSE AND THE OVERVIEW OF POTENTIAL TREATMENTS FOR COVID-19 TARGETING THE IMMUNE SYSTEM
DOI:
https://doi.org/10.36557/2674-8169.2024v6n4p2256-2275Keywords:
SARS-CoV-2, Coronavirus, COVID-19 and immune response, immunity, immunological markers, inflammation, inflammatory response.Abstract
To analyze the immunopathological aspects associated with SARS-CoV-2 infection, in addition to discussing potential therapeutic tools targeting immunological components. Method: This is a bibliographic review, with searches carried out in the PubMed database. Inclusion criteria were defined for articles that directly investigated the immunological and inflammatory response to SARS-CoV-2 infection, excluding reviews, articles in languages other than English and those not related to the immune system or the inflammatory response. After an initial search, 735 articles were identified and subjected to screening based on the established criteria. In the end, 65 articles were selected for the final review. Results: The study revealed that LDH and CRP levels decreased during hospitalization, while neutrophil counts decreased in critically ill patients, leading to a change in the immunological response. Several therapeutic approaches, such as monoclonal antibodies and mesenchymal cells, have been explored to modulate the inflammatory response, despite logistical and availability limitations. Conclusion: More studies are needed to understand the behavior of SARS-CoV-2 in critically ill patients and its mutations, changes in therapeutic approaches based on scientific evidence.
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Copyright (c) 2024 Anna Júlia Alves da Silva Campos, Lara Maia Duarte, Stela Firmino Soares Hostalácio, Bruno Cabral de Lima Oliveira
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