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Abstract
To conduct an integrative literature review to investigate patterns of brain activity in patients with delusions using functional and structural neuroimaging techniques. Methodology: A systematic search was conducted in the PubMed, Scopus, and Web of Science databases to identify studies investigating patterns of brain activity in patients with delusions using functional and structural neuroimaging. Studies published in the last 20 years and providing relevant data on functional connectivity and structural brain alterations in patients with delusions were included. Data were extracted and synthesized for qualitative analysis. Results: The integrative review identified 15 studies that met the inclusion criteria. The results indicated that patients with delusions often exhibit altered patterns of brain activity, including hyperactivity in cortical regions associated with emotional processing, such as the amygdala and ventromedial prefrontal cortex. Additionally, structural alterations were observed, including reduced gray matter volume in frontal and temporal cortical areas, as well as compromised integrity of white matter in projection and association tracts. Conclusion: The integrative review demonstrated that delusions are associated with altered patterns of brain activity, characterized by emotional hyperactivity and cognitive dysfunction. Furthermore, structural alterations observed in the brains of patients with delusions may contribute to the pathogenesis of these psychopathological symptoms. These findings underscore the importance of neuroimaging in understanding the neural mechanisms underlying delusions and highlight the need for further research to further elucidate these neural patterns.
References
Briggs R, Rinaldi D. O sujeito psicótico e a função do delírio. Rev latinoam psicopatol fundam [Internet]. 2014Sep;17(3):416–30. Available from: https://doi.org/10.1590/1415-4714.2014v17n3p416-3
Berrios GE. Delirium e confusão mental no século XIX: uma história conceitual. Rev latinoam psicopatol fundam [Internet]. 2011Mar;14(1):166–89. Available from: https://doi.org/10.1590/S1415-47142011000100012
Wacker P, Nunes PV, Forlenza OV. Delirium: uma perspectiva histórica. Arch Clin Psychiatry (São Paulo) [Internet]. 2005May;32(3):97–103. Available from: https://doi.org/10.1590/S0101-60832005000300001
Machado L, Cantilino A, Petribú K, Pinto T. Folie à deux (transtorno delirante induzido). J bras psiquiatr [Internet]. 2015Oct;64(4):311–4. Available from: https://doi.org/10.1590/0047-2085000000095
Esperidião-Antonio V, Majeski-Colombo M, Toledo-Monteverde D, Moraes-Martins G, Fernandes JJ, Assis MB de, et al.. Neurobiologia das emoções. Arch Clin Psychiatry (São Paulo) [Internet]. 2008;35(2):55–65. Available from: https://doi.org/10.1590/S0101-60832008000200003
Tenório F. Psicose e esquizofrenia: efeitos das mudanças nas classificações psiquiátricas sobre a abordagem clínica e teórica das doenças mentais. Hist cienc saude-Manguinhos [Internet]. 2016Oct;23(4):941–63. Available from: https://doi.org/10.1590/S0104-59702016005000018
Briggs R, Rinaldi D. O sujeito psicótico e a função do delírio. Rev latinoam psicopatol fundam [Internet]. 2014Sep;17(3):416–30. Available from: https://doi.org/10.1590/1415-4714.2014v17n3p416-3
Peres JFP, Newberg A. Neuroimagem e mediunidade: uma promissora linha de pesquisa. Arch Clin Psychiatry (São Paulo) [Internet]. 2013;40(6):225–32. Available from: https://doi.org/10.1590/S0101-60832013000600004
Santos FS. Mecanismos fisiopatológicos do delirium. Arch Clin Psychiatry (São Paulo) [Internet]. 2005May;32(3):104–12. Available from: https://doi.org/10.1590/S0101-60832005000300002
Costa Júnior F da, Medeiros M. Alguns conceitos de loucura entre a psiquiatria e a saúde mental: diálogos entre os opostos. Psicol USP [Internet]. 2007Mar;18(1):57–82. Available from: https://doi.org/10.1590/S0103-65642007000100004
Rocha ET, Alves TC, Garrido GE, Buchpiguel CA, Nitrini R, Busatto Filho G. Novas técnicas de neuroimagem em psiquiatria: qual o potencial de aplicações na prática clínica?. Braz J Psychiatry [Internet]. 2001May;23:58–60. Available from: https://doi.org/10.1590/S1516-44462001000500017
Calil LC, Terra JR. Síndrome de De Clèrambault: uma revisão bibliográfica. Braz J Psychiatry [Internet]. 2005Jun;27(2):152–6. Available from: https://doi.org/10.1590/S1516-44462005000200016
Caixeta L, Nitrini R. Teoria da mente: uma revisão com enfoque na sua incorporação pela psicologia médica. Psicol Reflex Crit [Internet]. 2002;15(1):105–12. Available from: https://doi.org/10.1590/S0102-79722002000100012
Tengan SK, Maia AK. Psicoses funcionais na infância e adolescência. J Pediatr (Rio J) [Internet]. 2004Apr;80(2):3–10. Available from: https://doi.org/10.1590/S0021-75572004000300002
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Copyright (c) 2024 Isabela Guerreiro Biccigo , Leonardo Schmidt de Morais, Zaine Dupim Dias , Manuella Teles Fernandes de Lima , Daniel Ferreira Cunha, Luiz Pedro Fernandes Bonfim, Rodrigo Barnabé Rodrigues, Juliana Maria de Andrade Mendes Pinto, Bárbara Fernanda Pacheco da Costa , Bianca de bonis Vieira, Zaine Dupim Dias , Glenda Ferreira Leite, Vinicius Klehm de Jesus , Clara Victoria Planinscheck , Karla Leticia Santos da Silva Costa