NEUROIMAGING AND DELUSIONS: DECIPHERING THE PATTERNS OF THE DELUSIONAL MIND
DOI:
https://doi.org/10.36557/2674-8169.2024v6n3p903-921Keywords:
Delusions; Neuroimaging; Brain Activity.Abstract
To conduct an integrative literature review to investigate patterns of brain activity in patients with delusions using functional and structural neuroimaging techniques. Methodology: A systematic search was conducted in the PubMed, Scopus, and Web of Science databases to identify studies investigating patterns of brain activity in patients with delusions using functional and structural neuroimaging. Studies published in the last 20 years and providing relevant data on functional connectivity and structural brain alterations in patients with delusions were included. Data were extracted and synthesized for qualitative analysis. Results: The integrative review identified 15 studies that met the inclusion criteria. The results indicated that patients with delusions often exhibit altered patterns of brain activity, including hyperactivity in cortical regions associated with emotional processing, such as the amygdala and ventromedial prefrontal cortex. Additionally, structural alterations were observed, including reduced gray matter volume in frontal and temporal cortical areas, as well as compromised integrity of white matter in projection and association tracts. Conclusion: The integrative review demonstrated that delusions are associated with altered patterns of brain activity, characterized by emotional hyperactivity and cognitive dysfunction. Furthermore, structural alterations observed in the brains of patients with delusions may contribute to the pathogenesis of these psychopathological symptoms. These findings underscore the importance of neuroimaging in understanding the neural mechanisms underlying delusions and highlight the need for further research to further elucidate these neural patterns.
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Copyright (c) 2024 Isabela Guerreiro Biccigo , Leonardo Schmidt de Morais, Zaine Dupim Dias , Manuella Teles Fernandes de Lima , Daniel Ferreira Cunha, Luiz Pedro Fernandes Bonfim, Rodrigo Barnabé Rodrigues, Juliana Maria de Andrade Mendes Pinto, Bárbara Fernanda Pacheco da Costa , Bianca de bonis Vieira, Zaine Dupim Dias , Glenda Ferreira Leite, Vinicius Klehm de Jesus , Clara Victoria Planinscheck , Karla Leticia Santos da Silva Costa
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