Keywords
COVID-19
Impactos na fertilidade masculina
reprodução
How to Cite
Abstract
Introduction: The emergence of the new strain of SARS-CoV (coronavirus) marked the onset of the pandemic of this disease, initially considered a condition that primarily affected the human respiratory system. However, recent studies indicate that the virus's impact is multisystemic, affecting various human organs, including the testicles. this raises the discussion about the virus's impact on male fertility. Objective: To establish the relationship between coronavirus infection and male infertility. Methodology: A qualitative literature review was conducted following these steps: defining the theme and research question, literature search, selecting materials compatible with the objective through critical analysis, reading and extracting key information, interpreting the results, and constructing the written review. For literature selection, articles on "The Relationship between COVID-19 and male infertility" and "The Relationship between SARS-CoV-2 and male infertility" were searched on databases, along with keywords such as "COVID-19," "Infertility," and "Male genital system." The most recent and relevant articles that aligned with the paper's objective were chosen. Results and Discussion: Among the identified articles, 11 were selected, revealing the presence of the ACE2 enzyme in the testicles, causing alterations in the realm of male reproduction. These alterations manifested as reductions in hormone concentrations, compromised semen quality, dysfunction of specific cells and their functions, evidenced by reduced sperm concentration, mobility, and retention, as well as inflammation (orchitis) and erectile dysfunction. Conclusion: All these findings underscore the need for further investigations into the topic and the development of treatments aimed at reversing the virus's impact on male fertility.
References
ABDEL-MONEIM, Adel. COVID-19 pandemic and male fertility: clinical manifestations and pathogenic mechanisms. Biochemistry (Moscow), v. 86, p. 389-396, 2021. https://doi.org/10.1134/S0006297921040015
AGOLLI, Arjola et al. SARS-CoV-2 effect on male infertility and its possible pathophysiological mechanisms. Discoveries, v. 9, n. 2, 2021. https://doi.org/10.15190/d.2021.10
ANIFANDIS, George et al. COVID-19 e fertilidade: uma realidade virtual. Biomedicina reprodutiva online, v. 41, n. 2, pág. 157-159, 2020. https://doi.org/10.1016/j.rbmo.2020.05.001
AZEVEDO, I.; FIGUEROA, P. Comentário: Os cirurgiões deveriam desafiar a sequela desconhecida do vírus da doença coronavírus 2019 (Covid-19)?. 2020.
BARRANTES, Francisco J. O desdobramento da síndrome multissistêmica COVID-19 e suas manifestações neurológicas. Cérebro, Comportamento e Imunidade-Saúde, v. 100251, 2021.
BEST, Jordan C. et al. Evaluation of SARS-CoV-2 in human semen and effect on total sperm number: a prospective observational study. The world journal of men's health, v. 39, n. 3, p. 489, 2021. https://doi.org/10.5534%2Fwjmh.200192
BRASIL, M. S. Cadernos de atenção básica. Departamento de Atenção Básica. 2013
CARNEIRO, Felipe et al. Padrões radiológicos de epididimite incidental em pacientes com COVID-19 leve a moderado revelados por ultrassonografia Doppler colorida. Andrologia, v. 53, n. 4, pág. e13973, 2021. https://dx.doi.org/10.1111/and.13973
DE MARQUI MILANI, Carolina et al. Influência da infecção por COVID-19 na fertilidade humana: uma revisão integrativa. CERES-Health & Education Medical Journal, v. 1, n. 1, p. 01-12, 2023. https://doi.org/10.62234/ceresv1n1-001
DIAS, Sara Almeida; FAZENDA, Juliana Maria; DE PAULA RAMOS, Lucas. Interferência do Covid-19 na fertilidade masculina. Research, Society and Development, v. 11, n. 15, p. e169111537211-e169111537211, 2022. https://doi.org/10.33448/rsd-v11i15.37211
DING, Ting et al. Análise de lesão ovariana associada à doença COVID-19 em mulheres em idade reprodutiva em Wuhan, China: um estudo observacional. Fronteiras na medicina, v. 8, p. 286, 2021. https://doi.org/10.3389/fmed.2021.635255
DONDERS, Gilbert GG et al. Sperm quality and absence of SARS-CoV-2 RNA in semen after COVID-19 infection: a prospective, observational study and validation of the SpermCOVID test. Fertility and Sterility, v. 117, n. 2, p. 287-296, 2022. https://doi.org/10.1016/j.fertnstert.2021.10.022
ERBAY, Guven et al. Short‐term effects of COVID‐19 on semen parameters: a multicenter study of 69 cases. Andrology, v. 9, n. 4, p. 1060-1065, 2021. https://doi.org/10.1111/andr.13019
FILHO, Antônio Hamilton Campos de Ávila. Et al. Sequelas sexuais e reprodutivas da Covid-19 em pacientes masculinos: uma revisão integrativa. Revista Científica Multidisciplinar Núcleo do Conhecimento. Ano. 07, Ed. 11, Vol.12. 2022. https://doi.org/10.32749/nucleodoconhecimento.com.br/saude/sequelas-sexuais
FRAIETTA, Renato et al. SARS-COV-2 and male reproductive health. JBRA Assisted Reproduction, v. 24, n. 3, p. 347, 2020. https://doi.org/10.5935%2F1518-0557.20200047
GAGLIARDI, Maria Cristina et al. ACE2 expression and sex disparity in COVID-19. Cell Death Discovery, v. 6, n. 1, p. 37, 2020. https://doi.org/10.1038/s41420-020-0276-1
GUL, Muhammad Hamdan; HTUN, Zin Mar; INAYAT, Asad. Role of fever and ambient temperature in COVID-19. Expert Review of Respiratory Medicine, v. 15, n. 2, p. 171-173, 2021. https://doi.org/10.1080/17476348.2020.1816172
HALLAK, Jorge et al. SARS-CoV-2 e sua relação com o trato geniturinário: Implicações para a saúde reprodutiva masculina no contexto da pandemia de COVID-19. Andrologia, v. 9, n. 1, pág. 73-79, 2021. https://doi.org/10.1111/andr.12896
HAMARAT, Mustafa Bilal et al. Effect of SARS-CoV-2 infection on semen parameters. Canadian Urological Association Journal, v. 16, n. 3, p. E173, 2022. https://doi.org/10.5489%2Fcuaj.7292
HOLTMANN, Nora et al. Avaliação do SARS-CoV-2 no sêmen humano – um estudo de coorte. Fertilidade e esterilidade, v. 114, n. 2, pág. 233-238, 2020. https://doi.org/10.1016/j.fertnstert.2020.05.028
KHALIL, Omar Arafat Kdudsi; DA SILVA KHALIL, Sara. SARS-CoV-2: taxonomia, origem e constituição. Revista de Medicina, v. 99, n. 5, p. 473-479, 2020. https://doi.org/10.11606/issn.1679-9836.v99i5p473-479
KHALILI, Mohammad Ali et al. Fertilidade masculina e a pandemia de COVID-19: revisão sistemática da literatura. A revista mundial de saúde masculina, v. 38, n. 4, pág. 506, 2020. https://doi.org/10.5534/wjmh.200134
KRESCH, Eliyahu et al. A disfunção endotelial COVID-19 pode causar disfunção erétil: estudo histopatológico, imuno-histoquímico e ultraestrutural do pênis humano. A revista mundial de saúde masculina, v. 39, n. 3, pág. 466, 2021. https://doi.org/10.5534/wjmh.210055
LI, Honggang et al. Espermatogênese prejudicada em pacientes com COVID-19. EClinicalMedicine, v. 28, 2020. https://doi.org/10.1016/j.eclinm.2020.100604
LI, Rong et al. Riscos potenciais da infecção por SARS-CoV-2 na saúde reprodutiva. Biomedicina reprodutiva online, v. 41, n. 1, pág. 89-95, 2020. https://doi.org/10.1016%2Fj.rbmo.2020.04.018
LIMA, Claudio Márcio Amaral de Oliveira. Information about the new coronavirus disease (COVID-19). Radiologia brasileira, v. 53, p. V-VI, 2020. https://doi.org/10.1590/0100-3984.2020.53.2e1
LINS, José Jefferson da Silva Cavalcanti et al. Relação entre infecção pelo SARS-CoV-2 e fertilidade masculina: o que é conhecido?. Research, Society and Development, v. 11, n. 12, p. e298111234670-e298111234670, 2022. https://doi.org/10.33448/rsd-v11i12.34670
MALEKI, Behzad Hajizadeh; TARTIBIAN, Bakhtyar. COVID-19 and male reproductive function: a prospective, longitudinal cohort study. Reproduction, v. 161, n. 3, p. 319-331, 2021. https://doi.org/10.1530/REP-20-0382
MANNUR, S. Declínio pós-COVID-19-associado na fertilidade masculina de longo prazo e na qualidade do embrião durante a tecnologia de reprodução assistida, 2021.
MONTEIRO, Tânita et al. Efeitos da infecção pelo Sars-Cov-2 no sistema reprodutor masculino. Revista Remecs-Revista Multidisciplinar de Estudos Científicos em Saúde, p. 11-17, 2021. https://doi.org/10.24281/rremecs2021.1.esp.11-17
MORSELLI, Simone et al. Inflamação do sistema reprodutor masculino após cura da doença coronavírus 2019. Andrologia, v. 6, pág. 1030-1037, 2022. https://doi.org/10.1111/andr.13138
MOURA, João Augusto Diniz; DE SOUZA FELIX, Ellen Mayara; PADILHA, Deborah de Melo Magalhães. COVID-19 e suas implicações na fertilidade masculina e feminina: impactos futuros. Research, Society and Development, v. 11, n. 16, p. e352111638217-e352111638217, 2022. https://doi.org/10.33448/rsd-v11i16.38217
PACHECO, Nágila Iane et al. Sintomatologia e o diagnóstico do novo coronavírus: uma revisão sistemática. Research, Society and Development, v. 9, n. 9, p. e859998172-e859998172, 2020. https://doi.org/10.33448/rsd-v9i9.8172
PAZIR, Yasar et al. Impaired semen parameters in patients with confirmed SARS‐CoV‐2 infection: a prospective cohort study. Andrologia, v. 53, n. 9, p. e14157, 2021. https://doi.org/10.1111/and.14157
PEIROUVI, Tahmineh et al. COVID-19 disrupts the blood–testis barrier through the induction of inflammatory cytokines and disruption of junctional proteins. Inflammation Research, v. 70, n. 10-12, p. 1165-1175, 2021. https://doi.org/10.1007/s00011-021-01497-4
RUAN, Yajun et al. No detection of SARS‐CoV‐2 from urine, expressed prostatic secretions, and semen in 74 recovered COVID‐19 male patients: a perspective and urogenital evaluation. Andrology, v. 9, n. 1, p. 99-106, 2021. https://doi.org/10.1111/andr.12939
SANTOS, Thiago et al. Como em diferentes tipos de células, a proteína ACE2 pode ter maior camada superficial como o Sars-CoV-2, independentemente da variante do vírus. 2022.
SCROPPO, Fabrizio I. et al. COVID-19 disease in clinical setting: impact on gonadal function, transmission risk, and sperm quality in young males. Journal of Basic and Clinical Physiology and Pharmacology, v. 33, n. 1, p. 97-102, 2021. https://doi.org/10.1515/jbcpp-2021-0227
SHARMA, Indu et al. SARS-CoV-2 and the reproductive system: known and the unknown..!!. Middle East Fertility Society Journal, v. 26, n. 1, p. 1-9, 2021. https://doi.org/10.1186%2Fs43043-020-00046-z
STRACCI, Juliana et al. Existe relação entre COVID-19 e infertilidade masculina? Is there a relationship between COVID-19 and male infertility?. 2021. Disponível em: https://pdf.blucher.com.br/medicalproceedings/comusc2021/01.pdf
TEMIZ, Mustafa Zafer et al. Investigation of SARS‐CoV‐2 in semen samples and the effects of COVID‐19 on male sexual health by using semen analysis and serum male hormone profile: A cross‐sectional, pilot study. Andrologia, v. 53, n. 2, p. e13912, 2021. https://doi.org/10.1111/and.13912
Tian Y, Zhou L. Evaluating the impact of COVID-19 on male reproduction. Reproduction. 2021; 161(2):R37-44. https://doi.org/10.1530/REP-20-0523
WANG, Zhengpin; XU, Xiaojiang. O perfil scRNA-seq de testículos humanos revela a presença do receptor ACE2, um alvo para infecção por SARS-CoV-2 em espermatogônias, células de Leydig e Sertoli. Células, v. 9, n. 4, pág. 920, 2020. https://doi.org/10.3390/cells9040920
XU, J. Orquite: uma complicação da síndrome respiratória aguda grave (SARS). 2020
YANG, Ming et al. Achados patológicos nos testículos de pacientes com COVID-19: implicações clínicas. Enfoque urológico europeu, v. 5, pág. 1124-1129, 2020. https://dx.doi.org/10.1016/j.euf.2020.05.009
YOUNIS, Johnny S.; ABASSI, Zaid; SKORECKI, Karl. Is there an impact of the COVID-19 pandemic on male fertility? The ACE2 connection. American Journal of Physiology-Endocrinology and Metabolism, 2020. https://doi.org/10.1152/ajpendo.00183.2020
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