Keywords
oral pemphigoid
oral pemphigoid treatment
How to Cite
Abstract
The pemphigoid of mucous membranes describes as a group of chronic mucocutaneous bullous diseases, autoimmune. Oral manifestations are perceived in most patients, but can occur in other locations, such as the conjunctival, nasal, esophageal, laryngeal and vaginal mucosa, as well as the skin. This paper aims to report a case of oral pemphigoid and review the current literature on the subject, such as the purpose of diagnosis and treatment. The literature review was conducted through a search in the scientific literature indexed in scientific databases such as Scielo, PubMed, Lilacs, Virtual Health Library and also academic theoretical bibliography. Although oral pemphigoid is not such a common condition in dental offices, knowledge about these oral lesions is extremely important, making the correct diagnosis and referring these patients to the appropriate treatment. With this we can conclude with this article that the pemphigoid of the mucous membrane is a chronic pathology, and in some cases it manifests itself in a more aggressive way, but rarely fatal. Therefore, treatment will depend on the location, rate of progression and severity of the manifestation of the pathology.
References
- NEVILLE, BW et al. Patologia oral e Maxilofacial. 3ª edição. Editora Guanabara Koogan, 2009.
- STAINES, K & HAMPTON, PJ. Treatment of mucous membrane pemphigoid with the combination of mycophenolate mofetil, dapsone, and prednisolone: a case series. Oral Med Oral Pathol Oral Radiol, 114 (1), 49- 56, 2012.
- BUONAVOGLIA, A et al. Pemphigus and mucous membrane pemphigoid: An update from diagnosis to therapy. Autoimmunity Reviews, Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Policlinico - 11, Piazza G. Cesare, 70124 Bari, Italy, 1568-9972, February 2019.
- BROUSSARD, KC et al. Autoimmune bullous diseases with skin and eye involvement: Cicatricial pemphigoid, pemphigus vulgaris, and pemphigus paraneoplastica. Clin Dermatol, v -34,205-213, 2016.
- CHAN, LS et al. The first international consensus on mucous membrane pemphigoid: definition, diagnostic criteria, pathogenic factors, medical treatment, and prognostic indicators. Arch Dermatol, v- 138, 370-379, 2002. 13
- RAMOS-E-SILVA M, FERREIRA A, JACQUES CMC. Oral involvement in autoimmune bullous diseases. J Clin Dermatol. v- 29, 443-454, 2011.
- FLEMING, TE & KORMAN, NJ. Cicatricial pemphigoid. J Am Acad Dermatol, v43(4): 571-91, 2000.
- JASCHOLT I, LAI O, ZILLIKENS D, KASPERKIEWICZ M. Periodontitis in oral pemphigus and pemphigoid: a systematic review of published studies. J Am Acad Dermatol 2017; 76(5):975–8. e3 https://doi.org/10.1016/j.jaad.2016.10.028.)
- SULIMAN, NM et al. Oral mucosal lesions in skin diseased patients attending a dermatologic clinic: a cross-sectional study in Sudan. BMC Oral Health, 11-24, 2011.
- ARDUINO, PG et al. Describing the gingival involvement in a sample of 182 Italian predominantly oral mucous membrane pemphigoid patients: A retrospective series. Med Oral Patol Oral Cir Bucal. v- 1; 22 (2), 52- 149, Mar 2017.
- MIGNOGNA MD, LO RUSSO L, FEDELE S. Gingival involvement of oral lichen planus in a series of 700 patients. J Clin Periodontol. 2005; 32:1029-33.
- CIZENSKI, JD et al. Spectrum of orocutaneous disease associations: Immune-mediated conditions. J Am Acad Dermatol, v-77 (5), 795–806, 2017. https://doi.org/10.1016/j.jaad.2017.02.019.
- FELLER, L et al. Immunopathogenic Oral Diseases: An Overview Focusing on Pemphigus Vulgaris and Mucous Membrane Pemphigoid. Oral Health Prev Dent. Department of Periodontology and Oral Medicine, Box D26 School of Dentistry, Medunsa 0204, South Africa. n- 2, v- 15, May 2017.
- TAYLOR J, MCMILLAN R, SHEPHARD M, SETTERFIELD J, AHMED R, CARROZZO M, et al. World Workshop on Oral Medicine VI: A systematic review of the treatment of mucous membrane pemphigoid. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;120(2):161-171.e20.
- CAREY, B & SETTERFIELD, J. Mucous membrane pemphigoid and oral blistering diseases. Clinical and Experimental Dermatology, Department of Oral Medicine, St John’s Institute of Dermatology, Guy’s and St Thomas’ NHS Foundation Trust, King’s College London, London, April 2019.
- BAGAN, JM. Mucosal disease series number III: mucous membrane pemphigoid. Oral Dis. v-11, 197-218, 2005.
- ORMOND M, MCPARLAND H, THAKRAR P, DONALDSON ANA, ANDIAPPAN M, COOK RJ, et al. Validation of an Oral Disease Severity Score (ODSS) tool for use in oral mucous membrane pemphigoid. Br J Dermatol. 2019.
- HAYAKAWA, T et al. Diagnosis of oral mucous membrane pemphigoid by means of combined serologic testing. Oral Surg Oral Med Oral Pathol Oral Radiol. 117:483–96, 2014.
- KAMAGUCHI, M; IWATA, H. The Diagnosis and Blistering Mechanisms of Mucous Membrane Pemphigoid. Frontiers in Immunology, v-10, Jan 2019.
- SANTI, CG et al. Consensus on the treatment of autoimmune bullous dermatoses: bullous pemphigoid, mucous membrane pemphigoid and epidermolysis bullosa acquisita – Brazilian Society of Dermatology. An Bras Dermatol, Work conducted at the Sociedade Brasileira de Dermatologia, Rio de Janeiro (RJ), Brazil. v-94, 33-47, January 2019.
- XU, H et al. Mucous Membrane Pemphigoid. Dent Clin North Am, v-57(4), 611-630, October 2013.
- CAREY, B et al. The optimal oral biopsy site for diagnosis of mucous membrane pemphigoid and pemphigus vulgaris. Br J Dermatol, 2019.
- JALIL BA, ABDOU YG, ROSEN SA, DAMMAD T. Mucous Membrane Pemphigoid Causing Central Airway Obstruction. J Bronchol Interv Pulmonol. 2017;24(4):334–8.
- SETTERFIELD JF, BLACK MM, CHALLACOMBE SJ. The management of oral lichen planus. Clin Exp Dermatol, v-25, 176–82, 2000.
- SACCUCCI, M et al. Autoimmune Diseases and Their Manifestations on Oral Cavity: Diagnosis and Clinical Management. Journal of Immunology Research May 2018.
- KAMAGUCHI et al. The identification of autoantigens in mucous membrane pemphigoid using immortalized oral mucosal keratinocytes. Oral Pathology & Medicine, v- 48, 60-67, May – September 2018.
- MALEY A, WARREN M, HABERMAN I, SWERLICK R, KHAROD-DHOLAKIA B, FELDMAN R. Rituximab combined with conventional therapy versus conventional therapy alone for the treatment of mucous membrane pemphigoid (MMP). J Am Acad Dermatol [Internet]. 2016;74(5):835–40. Available from: http://dx.doi.org/10.1016/j.jaad.2016.01.020
- SHIMANOVICH I, NITZ JM, WITTE M, ZILLIKENS D, ROSE C. Immunohistochemical diagnosis of mucous membrane pemphigoid. J Oral Pathol Med. 2018;47(6):613–9. 16
- KRIDIN, K. Peripheral eosinophilia in bullous pemphigoid: prevalence and influence on the clinical manifestation. Br J Dermatol. v-179, 1141–7, 2018.
- DDS, YVBO et al. Sjögren Syndrome and Mucous Membrane Pemphigoid in a Patient with a History of Thymoma: Case Report and Literature Review. ODOVTOS-Int. J Dental Sc., v-21(2), 33-44, Mai – August, 2019.
- GONÇALO, RIC et al. Vesiculobullous autoimmune diseases with oral mucosa manifestations: retrospective and follow-up study. RGO, Rev Gaúch Odontol, Av. Senador Salgado Filho, 1757, Lagoa Nova, Natal, RN, Brasil, v-66 (1), 42-4, Jan – Mar 2018.
- ISMAILI, AA et al. Immune-mediated Skin Disorders and their Oral Manifestations in the Omani Population: A Hospital-based Study. Oman Medical Journal, v-35 (1), 84, Jan 2020.
- SILVA, BSF et al. Systemic corticosteroid in the treatment of a 9-year-old boy with oral mucous membrane pemphigoid: a case report. Rev Odontol Bras Central, Av. Universitária, km 3,5. Anápolis - GO, Brasil, v-26(76), 41-44, Jan – Mar 2017.
- MURREAL, DF et al. Definitions and outcome measures for mucous membrane pemphigoid: Recommendations of an international panel of experts. J AM ACAD 15 DERMATOL, St George Hospital, University of New South Wales, Gray St, Kogarah, Sydney, N8W 2317 Australia, v- 72 (1), 168-174, January 2015.
- XU, H et al. Mucous Membrane Pemphigoid. Dent Clin North Am, v-57(4), 611-630, October 2013.
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