Clorexidina como inibidora de metaloproteinases na dentina: implicações na estabilidade da interface adesiva
DOI:
https://doi.org/10.36557/2674-8169.2026v8n7p408-434Palavras-chave:
Clorexidina, Metaloproteinases, Dentina, Camada híbrida, Adesão dentináriaResumo
A estabilidade da interface adesiva dentinária permanece como um dos principais desafios da odontologia restauradora contemporânea, especialmente devido à degradação progressiva da camada híbrida e da matriz colagenosa exposta. Nesse contexto, as metaloproteinases da matriz (MMPs), enzimas endógenas presentes na dentina, desempenham papel relevante na degradação do colágeno e na redução da resistência de união ao longo do tempo. A clorexidina tem sido investigada como agente inibidor dessas enzimas, apresentando potencial para preservar a matriz orgânica e aumentar a longevidade da adesão dentina-resina. Este estudo teve como objetivo analisar o papel da clorexidina como inibidora de MMPs na dentina e suas implicações na estabilidade da interface adesiva. Trata-se de uma revisão integrativa da literatura, realizada nas bases PubMed/MEDLINE, SciELO, ScienceDirect/Elsevier e Connected Papers, incluindo estudos in vitro, in vivo, ensaios clínicos, revisões sistemáticas, metanálises e artigos clássicos relacionados à adesão dentinária, camada híbrida, MMPs e clorexidina. Os achados indicam que a clorexidina pode reduzir a atividade proteolítica das MMPs por meio da interação com íons metálicos essenciais à sua função catalítica, contribuindo para a preservação da camada híbrida, principalmente em sistemas etch-and-rinse. Entretanto, sua efetividade é variável e depende do sistema adesivo, concentração, tempo de aplicação e protocolo clínico. Pode-se observar que a clorexidina apresenta papel relevante na preservação da interface adesiva, embora não seja capaz de impedir isoladamente todos os mecanismos de degradação.
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Copyright (c) 2026 Ana Clara Cândido Vasconcelos, Thallison Matheus Lisboa Fernandes , Michelle Leão Bittencourt Brandão Medeiros
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
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