Retreatment in Congenital Syphilis Following Serologic Titer Elevation
DOI:
https://doi.org/10.36557/2674-8169.2026v8n4p370-375Palavras-chave:
Congenital syphilis, Retreatment, Follow-upResumo
Congenital syphilis results from transplacental transmission of Treponema pallidum in pregnant women with active infection and remains a significant public health concern. Although it is a potentially curable condition, it requires systematic clinical and serological follow-up, including serial monitoring of non-treponemal tests such as the Venereal Disease Research Laboratory (VDRL) test to assess therapeutic response. We report the case of an infant with confirmed congenital syphilis who, despite receiving guideline-recommended treatment, exhibited a subsequent rise in non-treponemal titers during outpatient follow-up. This case raises important considerations regarding the interpretation of post-treatment serologic dynamics and the potential determinants of titer elevation, including therapeutic failure, reinfection, or atypical serologic response, thereby underscoring the need for rigorous longitudinal surveillance in exposed children.
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Copyright (c) 2026 Julia Tabile Casanova, Anne Caroline Sabóia de Souza Caria, Nicole da Silva Galina, Gabrielle Alencar Mariote, Maria Eduarda Pinheiro Nogueira, Ingrid Condor Loureiro da Silva, Victoria Gomes Cosendei, Thiago Souza Queiroz, Yuri dos Santos Bezerra, Juliana Maciel Martins, Tainá Pinto de Lima, João Henrique Lima Bittencourt, Jamille Meireles Santos, Jeniffer Raugust Peixoto; Alex Moreira Souza
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Os autores são detentores dos direitos autorais mediante uma licença CCBY 4.0.
