Dor crônica e biomarcadores inflamatórios em mulheres com obesidade: Impacto dos Fenótipos Adiposos e Lipedema
DOI:
https://doi.org/10.36557/2674-8169.2026v8n2p869-884Palavras-chave:
Obesidade, Lipedema, Biomarcadores Inflamatórios, Dor CrônicaResumo
Introdução: Dor crônica em mulheres com obesidade pode resultar de interações entre distribuição de gordura (androide vs ginoide), inflamação sistêmica e fenótipos de tecido adiposo doloroso, incluindo lipedema. Objetivo: Sintetizar criticamente evidências (2020–2025) sobre a relação entre intensidade da dor e marcadores inflamatórios em mulheres com obesidade, contrastando fenótipos androide/ginoide e integrando lipedema como confundidor ou fenótipo específico. Métodos: Revisão narrativa com busca estruturada em PubMed/MEDLINE e Google Scholar (2020–2025), combinando descritores para obesidade, distribuição de gordura, dor crônica, inflamação e lipedema; seleção por relevância clínica/metodológica e extração de dados sobre fenotipagem corporal, desfechos de dor, painéis inflamatórios e controle de confundidores. Resultados: Os achados são heterogêneos; diferenças na mensuração de adiposidade (visceral vs subcutânea), nos painéis de biomarcadores e no controle de confundidores limitam comparações. Lipedema pode concentrar dor no fenótipo periférico e enviesar análises quando não identificado. Conclusão: A interpretação de dor–inflamação em mulheres com obesidade requer fenotipagem objetiva da distribuição corporal e triagem sistemática de lipedema para separar mecanismos metabólico-inflamatórios de mecanismos subcutâneos dolorosos.
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Copyright (c) 2026 Paulo André Dias da Silva, Reginaldo Costa da Silva Junior, Tiago dos Santos Brito, Diórgenes Rodrigues Cardoso, Yasmin Santiago Paixão, Felipe de Castro dos Santos, Israel Dias Nonato, Igor Gomes de Oliveira, Gabriel Jersemi Rodrigues Costa, Manuel Dionizio Bentes Monteiro Neto, Carolyna Tereza Brasil Papaléo, Maria Eduarda de Lima Dacier Lobato, José Rodrigo Moraes Teles, Vitor Cayke Savedra Dias, Amanda Beatriz Pinheiro Macedo
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Os autores são detentores dos direitos autorais mediante uma licença CCBY 4.0.
