Potencial Terapêutico do Ozônio em Odontologia: Avanços e Perspectivas: Revisão de Literatura
DOI:
https://doi.org/10.36557/2674-8169.2025v7n9p165-190Palavras-chave:
Ozonioterapia, Ozonioterapia e Odontologia, Cicatrização, Propriedades AntimicrobianasResumo
Em virtude de suas propriedades antimicrobianas, cicatrizantes, anti-inflamatórias, antifúngicas e imunomoduladoras, o emprego do ozônio tem sido amplamente difundido como terapia complementar na área da saúde. Na odontologia, a ozonioterapia também vem sendo cada vez mais divulgada como tratamento auxiliar nas diferentes áreas odontológicas, mostrando-se como uma alternativa promissora, efetiva e segura para fins terapêuticos. Diante desse cenário, o presente estudo tem como objetivo ressaltar, por meio de uma revisão de literatura, os principais aspectos relacionados ao gás ozônio, seu uso terapêutico nas diferentes especialidades odontológicas, além de seus avanços e perspectivas futuras.
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AKTURK, Ezgi Zekiye et al. Do ozonated water and boric acid affect the bond strength to dentin in different adhesive systems?. Nigerian Journal of Clinical Practice, v. 22, n. 12, p. 1758-1764, 2019. DOI: 10.4103/njcp.njcp_281_19.
ALSHERIF, Aya Anwar; ELTOKHEY, Heba Mohamed; TAIEMA, Doaa Ameen. Platelet rich fibrin versus ozone gel for periodontal regeneration in induced rats’ intrabony three-wall periodontal defects. Journal of Oral Biology and Craniofacial Research, [S.l.], v. 10, n. 4, p. 639–649, 2020. DOI: https://doi.org/10.1016/j.jobcr.2020.09.001.
ANZOLIN, Ana Paula.; DA SILVEIRA-KAROSS, Nayara Liane.; BERTOL, C. Ozonated oil in wound healing: what has already been proven? Medical Gas Research, v. 10, n. 1, p. 54, 2020. DOI: 10.4103/2045-9912.279985
BARCZYK, Izabela et al. Potential Clinical Applications of Ozone Therapy in Dental Specialties—A Literature Review, Supported by Own Observations. International Journal of Environmental Research and Public Health, v. 20, n. 3, p. 2048, 2023.
BASTOS, Poliana Lima et al. Ozonioterapia na odontologia: revisão sistemática de literatura. Research, Society and Development, v. 11, n. 4, p. e46711427474 2022.
BRITO CHAVES, Tauane Procópio de; MARTINEZ, Carlos Henrique Mancia; CAMPOS, Francisco Ubiratan Ferreira de. Ozonioterapia aplicada na odontologia:revisão de literatura. Revista Eletrônica de Ciências Jurídicas, V.7, n.1, p.01-20, 2022.
BRITO JÚNIOR, Anildo. Alves de. et al. Aplicação de óleos ozonizados no corpo humano e sistemas de cavidade oral. RGO - Revista Gaúcha de Odontologia, v. 70, 2022.
CONSELHO REGIONAL DE ODONTOLOGIA DE SÃO PAULO. Esclarecimentos sobre Ozonioterapia na Odontologia. 2018. Disponível em: https://crosp.org.br/noticia/esclarecimentos-sobre-ozonioterapia-na-odontologia/. Acesso em: 01 de agosto de 2025.
COSTA, Lucas Felipe Pereira.; ASSUNÇÃO, Victoria Irês. Pereira. Ozonioterapia aplicada a cirurgia oral: Revisão de literatura. Trabalho de Conclusão de Curso (Graduação em Odontologia). Universidade do Grande Rio “Professor José de Souza Herdy”, 2020.
DI FEDE, Olga. et al. Ozone infiltration for osteonecrosis of the jaw therapy: a case series. Journal of Clinical Medicine, v. 11, n. 18, p. 5307, 2022. Disponível em: https://doi.org/10.3390/jcm11185307. Acesso em: 16 jul. 2025
DIETRICH, Lia. et al. Ozone therapy in the treatment of recurrent herpes labialis: a clinical case report. Research, Society and Development, [S. l.], v. 9, n. 10, p. e1349108418, 2020. DOI: 10.33448/rsd-v9i10.8418. Disponível em: https://rsdjournal.org/rsd/article/view/8418. Acesso em: 11 aug. 2025.
DUARTE, Sérgio.; PANARIELLO, Bruno. Henrique. Damião. Comprehensive biomedical applications of low temperature plasmas. Archives of Biochemistry and Biophysics, v. 693, p. 108560, 2020. DOI: https://doi.org/10.1016/j.abb.2020.108560
FARZAD, Ghorbani. et al. Effect of Ozonated Water on Oral Mucositis and Pain Induced by Head and Neck Radiotherapy: A Cross-sectional Study. Archives of Neuroscience, v. 8, n. 4, e118914, 2021. DOI: https://doi.org/10.5812/ans.118914.
FERREIRA, Mário Jorge Filho. et al. The use of ozonized oil in the healing process after dental implant surgery: literature review. Brazilian Journal of Development, v. 6, n. 11, p. 93559–93567, 2020.DOI:https://doi.org/10.34117/bjdv6n11-682.
FLOARE, Alin. Daniel. et al. Ozone and microstructural morphological changes of tooth enamel. Romanian Journal of Morphology and Embryology, [S.l.], v. 63, n. 3, p. 539–544, 2022.
FLOR, Lara Carolyne. de Souza. et al. Fatores associados aos acidentes e complicações na extração de terceiros molares: uma revisão de literatura. Research, Society and Development, v. 10, n. 10, p. e281101018932, p.1-6 2021.
FREITAS, Fernanda Alves de et al. Ozonioterapia na odontologia: uma revisão de literatura. Revista Brasileira Multidisciplinar, v. 26, n. 1, 2023.
GALLO, Simone.; SCRIBANTE, Andrea. Ozone therapy in dentistry: from traditional applications towards innovative ones. A review of the literature. In: IOP CONFERENCE SERIES: EARTH AND ENVIRONMENTAL SCIENCE, 2021. v. 707, n. 1, p. 012001. Disponível em: https://iopscience.iop.org/article/10.1088/1755-1315/707/1/012001/pdf.
GARCIA, Nathana. et al. Utilização da ozonioterapia em odontologia. Brazilian Journal of Development, v. 7, n. 1, p. 8797–8711, 2021. DOI: https://doi.org/10.34117/bjdv7n1-589
GHOSH, Dibakar. et al. Comparison of efficacy of ozonated water, normal saline, and povidone-iodine after surgical removal of impacted mandibular third molars: a cross-sectional study. Journal of Family Medicine and Primary Care, v. 9, n. 8, p. 4139, 2020.
GLÓRIA, José Cristiano Ramos. et al. Influence of ozonized water on pain, oedema, and trismus during impacted third molar surgery: a randomized, triple blind clinical trial. BMC Saúde Bucal, v. 20, n. 1, p. 1-9, 2020.
GOKER, Furkan. et al. Treatment of BRONJ with ozone/oxygen therapy and debridement with piezoelectric surgery. European Review for Medical and Pharmacological Sciences, v. 24, n. 17, p. 9094-9103, 2020. Disponível em: https://www.europeanreview.org/article/22855. Acesso em: 16 jul. 2025.
GROCHOLEWICZ, Katarzyna et al. Effect of nano-hydroxyapatite and ozone on approximal initial caries: a randomized clinical trial. Scientific Reports, [S.l.], v. 10, n. 1, p. 11192, 2020. DOI: https://doi.org/10.1038/s41598-020-67885-.
HUTH, Karin C. et al. Effect of ozone on oral cells compared with established antimicrobials. European Journal of Oral Sciences, Oxford, v. 114, n. 5, p. 435–440, out. 2006. Disponível em: https://doi.org/10.1111/j.1600-0722.2006.00390.x.
ISLER, Sila Cagri. et al. The effects of ozone therapy as an adjunct to the surgical treatment of peri-implantitis. Journal of Periodontal & Implant Science, [S.l.], v. 48, n. 3, p. 136–151, 2018. DOI: https://doi.org/10.5051/jpis.2018.48.3.136.
JÚNIOR, Anísio Rodiney Souza. et al. Ozone as adjuvant in surgical and non-surgical periodontal therapy: an integrative review. Research, Society and Development, [S. l.], v. 10, n. 13, 2021. DOI: https://doi.org/10.33448/rsd-v10i13.21603
KALASKAR, Ashita. et al. Antimicrobial effect of ozone therapy in deep dentinal carious lesion: a systematic review. International Journal of Clinical Pediatric Dentistry, v. 15, n. S2, p. S252–S260, 2022.
KRUNIĆ, Jelena et al. Clinical antibacterial effectiveness and biocompatibility of gaseous ozone after incomplete caries removal. Clinical Oral Investigations, v. 23, n. 2, p. 785–792, 2019. Disponível em: https://doi.org/10.1007/s00784-018-2495-x. Acesso em: 18 jul. 2025.
KUMAR, Anil. et al. Evidence-based effectiveness of Ozone therapy in the treatment for oral lichen planus - A systematic review. National Journal of Maxillofacial Surgery, v. 15, n. 1, p. 18-22, jan.-abr. 2024.
LEEWANANTHAWET, Anongwee. et al. Ozone ultrafine bubble water induces the cellular signaling involved in oxidative stress responses in human periodontal ligament fibroblasts. Science and Technology of Advanced Materials, [S.l.], v. 20, n. 1, p. 589–598, 2019. DOI: https://doi.org/10.1080/14686996.2019.1614980.
LIMA, Willian Barbosa de et al. O papel do ozônio no controle de infecções na odontologia. Brazilian Journal of Development, v. 6, n. 10, p. 81085–81095, 2020.
MARCHESINI, Bruna. Fuhr.; RIBEIRO, Silene. Bazi. Efeito da ozonioterapia na cicatrização de feridas. Fisioterapia Brasil, p. 281–288, 2020. Disponível em: https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1283097. Acesso em: 16 jul. 2025.
MESE, Mehmet et al. Influence of ozone application in the stepwise excavation of primary molars: a randomized clinical trial. Clinical Oral Investigations, v. 24, n. 10, p. 3529–3538, 2020. Disponível em: https://doi.org/10.1007/s00784-020-03223-6. Acesso em: 18 jul. 2025.
MINISTÉRIO DA SAÚDE (MS). Portaria n° 702, de 21 de março de 2018. Disponível em:
https://bvsms.saude.gov.br/bvs/saudelegis/gm/2018/prt0702_22_03_2018.html. Acesso em: 01 de agosto de 2025.
MORASCHINI, Vittorio. et al. Ineffectiveness of ozone therapy in nonsurgical periodontal treatment: a systematic review and metaanalysis of randomized clinical trials. Clinical Oral Investigations, v. 24, p. 1877-1888, 2020. DOI: https://doi.org/10.1007/s00784-020-03289.
MOSTAFA, Basma. et al. Evaluation of the effect of ozonated water in treatment of denture stomatitis associated with removable prosthetics. Bulletin of the National Research Centre, v. 48, Art. 1, 02 jan. 2024. DOI: 10.1186/s42269-023-01151-5. Disponível em: https://bnrc.springeropen.com/articles/10.1186/s42269-023-01151-5.
NEKHAY, Oleg. et al. Mechanisms of Ozone Action in Dentistry. Dentistry Journal, v. 9, n. 10, p. 112–125, 2021.
ÖZALP, Ömer Faruk. et al. Comparing the effects of low-level laser therapy and gaseous ozone as a preventive measure on medication-related osteonecrosis of the jaws following tooth extraction: a rat model. European Journal of Medical Research, v. 29, n. 1, p. 359, 9 jul. 2024.
PÁEZ, Thalita Toffoli. et al. Ozonioterapia e seus aspectos controvertidos. Diálogos Interdisciplinares, v. 9, n. 5, p. 1–21, 2020.
PCHEPIORKA, Robson. et al. Effect of ozone therapy on wound healing in the buccal mucosa of rats. Archives of Oral Biology, v. 119, n. 104889, nov. 2020
PHILOZON. Ozônio medicinal e produtos ozonizados na cicatrização de feridas. Joinville: Editora Philozon, p.1-42 2020. Disponível em: https://pt.scribd.com/document/496028956/Ebook-ozonio-medicinal-cicatrizao-Philozon. Acesso em: 4 jun. 2025.
PRAIZNER, Matheus. Ozonioterapia: aplicações do ozônio de forma auxiliar no cotidiano odontológico. Guarapuava: Centro Universitário UniGuairacá, p. 1-27. 2020. Trabalho de Conclusão de Curso (Graduação em Odontologia).
PRESTES, L. V. et al. Aplicabilidade da ozonioterapia na odontologia: uma revisão de literatura. Arquivos de Ciências da Saúde UNIPAR, v. 24, n. 3, p. 203-208, 2020
RAMALHO, Celina. Análise econômico-financeira do uso da ozonioterapia como parte do tratamento de patologias. São Paulo: [s.n.], 2017. Disponível em: http://www.celinaramalho.com.br. Acesso em: 11 ago. 2025.
RAMIREZ-PEÑA, Ana Maria. et al. Ozone in patients with periodontitis: a clinical and microbiological study. Journal of Clinical Medicine, [S.l.], v. 11, n. 10, p. 2946, 2022. DOI: 10.3390/jcm11102946
RANJITHA, Gracelin. et al. Efficacy of Ozone Therapy and Low-Level Laser Therapy in Treating Premalignant and Malignant Lesions: A Systematic Review. Journal of Pharmacy and Bioallied Sciences, v. 16, supl. 5, p. S4284-S4288, dez. 2024.
RAPONE, Biagio. et al. The effect of gaseous ozone therapy in conjunction with periodontal treatment on glycated hemoglobin level in subjects with type 2 diabetes mellitus: an unmasked randomized controlled trial. International Journal of Environmental Research and Public Health, [S.l.], v. 17, n. 15, p. 5467–5478, 2020. DOI: https://doi.org/10.3390/ijerph17155467.
RODRIGUES, Carolaine Nunes et al. Uso da ozonioterapia como coadjuvante ao tratamento endodôntico. Contribuciones a Las Ciencias Sociales, São José dos Pinhais, v. 16, n. 9, p. 15877–15887, 2023.
SÁ, Teresa Dávila Castro de. Ozonioterapia na Odontologia. 2021. 27 f. Trabalho de Conclusão de Curso (Graduação em Odontologia) – Faculdade Pitágoras, Imperatriz, 2021.
SABBAH, Fadi et al.** Ozone therapy in dentistry – where we are and where we are going to? *Ozone Therapy Global Journal*, v. 8, n. 1, p. 37–63, 2018.
SANTOS, Bharbara Bonnie dos. et al. Controle de infecção oral com ozonioterapia: revisão de literatura. Investigação, Sociedade e Desenvolvimento, v. 11, n. 7, 2022.
SCHWENDICKE, Falk et al. Interventions for treating cavitated or dentine carious lesions. The Cochrane Database of Systematic Reviews, [s.l.], v. 7, n. 7, p. CD013039, 2021. DOI: https://doi.org/10.1002/14651858.CD013039.pub2. Disponível em: https://doi.org/10.1002/14651858.CD013039.pub2. Acesso em: 04 jun. 2025.
SEN, Suman.; SEN, Sheuli. Ozone therapy a new vista in dentistry: integrated review. Medical Gas Research, v. 10, n. 4, p. 189, 2020.
SERRA, Maria. Emília. Gomes. et al. The role of ozone treatment as integrative medicine: an evidence and gap map. Frontiers in Public Health, v. 10, e1112296, 2023. DOI: https://doi.org/10.3389/fpubh.2023.1112296.
SHEKHAR, Abhinav et al. An evaluation of the effect of ozone therapy on tissues surrounding dental implants. International Immunopharmacology, v. 96, p. 107588, 2021. DOI: https://doi.org/10.1016/j.intimp.2021.107588.
SILVA, Camila Barbosa da. et al. Ozone therapy in dentistry: review of major scientific considerations. International Journal of Development Research, v. 10, n. 4, p. 35060–35063, 2020.
SILVA, Emmanuel João Nogueira Leal et al. The effect of ozone therapy in root canal disinfection: a systematic review. International Endodontic Journal, v. 53, n. 3, p. 317–332, 2020. DOI: 10.1111/iej.13229.
SILVA, Helessandra Matias da et al. Aplicação da ozonioterapia na odontologia: revisão integrativa. Revista Eletrônica Acervo Saúde, v. 13, n. 8, p. e8648, 2021.
SILVA, Roberto. Terapias orais utilizando ozônio: estudos sobre osteonecroses maxilares. Revista Brasileira de Odontologia, v. 35, p. 110-118, 2020.
SILVA, Rodrigo José et al. Aplicações terapêuticas do ozônio: uma abordagem multidisciplinar. Revista Saúde e Ciência Online, v. 11, n. 1, 2022.
SILVA, Yngrid da Cruz et al. Ozônio como agente antimicrobiano na odontologia: revisão de literatura. Revista da Faculdade de Odontologia da Universidade Federal da Bahia, v. 51, n. 3, p. 97–107, 2021.
SOUZA, José Reinaldo Araújo; KRUKOSKI, Daniel Witchmichen. Ozonioterapia no tratamento de canais radiculares. Aesthetic Orofacial Science, Curitiba, v. 1, n. 1, p. 20–26, 2020.
SWANSON, Terrell J.; JAMAL, Zohaib; CHAPMAN, Jennifer. Ozone toxicity. In: STATPEARLS. Treasure Island (FL): StatPearls Publishing, 2020. Disponível em: https://www.ncbi.nlm.nih.gov/books/NBK430751/. Acesso em: 4 ago. 2025. ISBN: 978-1-64078-580-4
TALMAÇ, Ahmet Cemil; ÇALIŞIR, Metin. Efficacy of gaseous ozone in smoking and non-smoking gingivitis patients. Irish Journal of Medical Science, [S.l.], v. 190, n. 1, p. 325–333, 2021. Disponível em: https://pmc.ncbi.nlm.nih.gov/articles/PMC7604462/. Acesso em: 4 jun. 2025.
TARTARI, Ana Paula Santos et al. Anti-inflammatory effect of ozone therapy in an experimental model of rheumatoid arthritis Inflammation, [S.l.]. National institutes of Health. v. 43, n. 3, p. 985–993, 2020. Disponível em: https://link.springer.com/article/10.1007/s10753-020-01184-2. Acesso em: 4 jun. 2025.
TRICARICO, Gerardo et al. A critical evaluation of the use of ozone and its derivatives in dentistry. European Review for Medical and Pharmacological Sciences, [S.l.], v. 24, n. 17, p. 9071–9093, 2020. Disponível em: https://www.europeanreview.org/article/22854. Acesso em: 4 jun. 2025.
TORTELLI, S. A. C., Saraiva, L., & Miyagaki, D. C. (2020). Effectiveness of acupuncture, ozone therapy and low-intensity laser in the treatment of temporomandibular dysfunction of muscle origin: a randomized controlled trial. Revista de Odontologia da UNESP, 48, e20200017. https://doi.org/10.1590/1807-2577.10719
VENERI, Federica. et al. Efficacy of ozonized water for the treatment of erosive oral lichen planus: a randomized controlled study. Medicina Oral, Patología Oral y Cirugía Bucal, v. 25, n. 5, p. e675-e682, 2020. DOI: 10.4317/medoral.23597. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473429/. Acesso em: 11 ago. 2025.
VENERI, Federica et al. Ozone therapy in dentistry: An overview of the biological mechanisms involved. Biomedical Reports, v. 21, n. 2, p. 115, 2024. DOI: 10.3892/br.2024.1803
VIEIRA, Mateus. Silva.; BRAZ, Rodrigo. Duarte. Ferreira.; SILVA, Larissa. Carvalho. Ozonioterapia em procedimentos odontológicos: revisão literária. Pesquisa, Sociedade e Desenvolvimento, v. 11, n. 15, p. e148111536877-e148111536877, 2022. DOI: 10.33448/rsd-v11i15.36877.
WEN, Qing et al. A systematic review of ozone therapy for treating chronically refractory wounds and ulcers. International Wound Journal, [S.l.], v. 19, n. 4, p. 853–870, 2022. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013593/. Acesso em: 4 jun. 2025.
ZENG, Jinrong et al. Ozonated autohemotherapy elevates PPAR-γ expression in CD4⁺ T cells and serum HDL-C levels, a potential immunomodulatory mechanism for treatment of psoriasis. American Journal of Translational Research, [S.l.], v. 13, n. 1, p. 349–359, jan. 2021. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847517/. Acesso em: 4 jun. 2025.
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Copyright (c) 2025 Jéssica Karoline Pereira de Lima, Patrícia Gizeli Brassali de Melo Ribeiro, Ana Beatriz Andrade Almeida, Pamela Vitória Moreira dos Santos, Rafaela Farias
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