Atualizações em Suporte Hemodinâmico e Estratégias Terapêuticas no Choque Séptico

Autores

  • Marina Silva Camarço Lima Médica pela Unifacid Wyden https://orcid.org/0000-0002-7694-8426
  • Francisco Javier Gonzalez Benítez Médico - Especialista en Medicina Interna Facultad de Ciencias de la Salud - Universidad Nacional del Este Paraguay https://orcid.org/0009-0008-9208-4198
  • José Antonio Moreira Parra Especialista en Medicina Interna Facultad de Ciencias de la Salud - Universidad Nacional del Este Paraguay
  • Lucas Pedro Fernandes Médico formado pela Universidade de Taubaté. Residente de 2⁰ ano de Clínica Médica do Hospital Municipal Universitário de Taubaté (HMUT) https://orcid.org/0009-0006-2747-4056
  • Fernando Bernardino Hashimoto Médico - Universidade de Taubaté(SP)
  • Letícia Caparroz Médica - Universidade de Taubaté(SP)
  • Felipe de Azevedo Soares Alvarenga Residente de clínica médica pela Santa Casa de São Paulo https://orcid.org/0009-0004-6710-6245
  • Victoria Gabriele Marcitelli dos Santos Médica formada pela Universidade de Taubaté
  • Ian de Almeida Pernambuco Sachs Residente de clínica médica na Unitau https://orcid.org/0009-0000-6558-6397
  • Gabriela Bittencourt Duarte Villela Faculdade de medicina de Petrópolis- RJ
  • Charllyes Rodrigues Médico pela Universidad Abierta Interamericana https://orcid.org/0009-0001-2590-858X
  • Filippi Valentino Agostinho Villarta Médico formado pela Universidade de Taubaté, residente do primeiro ano de Clínica Médica do Hospital Municipal Universitário de Taubaté
  • Rúbia Laureano de Toledo Médica formada na Universidade Cidade de São Paulo residente do primeiro ano, de Clínica Médica, no Hospital Municipal Universitário de Taubaté
  • Marcelo Fernandes Roma Médico graduado pela Faculdade de Medicina de Itajubá residente de primeiro ano do hospital municipal universitario de Taubaté https://orcid.org/0000-0003-2553-2313

DOI:

https://doi.org/10.36557/2674-8169.2025v7n7p1672-1686

Palavras-chave:

Choque séptico; Hemodinâmica; Reposição volêmica.

Resumo

O choque séptico representa uma condição crítica com alta mortalidade e morbidade, sendo um estágio avançado da sepse associado à disfunção circulatória e hipoperfusão tecidual. Esta revisão narrativa analisa as principais estratégias de suporte hemodinâmico baseadas em evidências atuais, com foco na reanimação volêmica, uso de vasopressores e indicadores dinâmicos de perfusão. Foram incluídos 30 estudos selecionados nas bases SciELO, PubMed, BVS e Microsoft Academic Search, publicados entre 2021 e 2024. A terapia guiada por metas precoces, embora amplamente adotada, tem sido questionada por recentes ensaios clínicos quanto à sua efetividade. A reanimação deve priorizar o uso de cristaloides, noradrenalina como vasopressor de escolha e monitoramento de parâmetros como lactato, SvO₂ e variação da pressão de pulso. Métodos dinâmicos como ultrassom da veia cava e teste de elevação passiva das pernas auxiliam na avaliação da responsividade volêmica. Conclui-se que o manejo individualizado e precoce, guiado por parâmetros clínicos e laboratoriais, é fundamental para melhorar os desfechos em pacientes com choque séptico.

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Referências

- ANGUS, Derek C. et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Critical care medicine, v. 29, n. 7, p. 1303-1310, 2001.

- GAIESKI, David F. et al. Benchmarking the incidence and mortality of severe sepsis in the United States. Critical care medicine, v. 41, n. 5, p. 1167-1174, 2013.

- GIAMARELLOS-BOURBOULIS, Evangelos J. et al. The pathophysiology of sepsis and precision-medicine-based immunotherapy. Nature immunology, v. 25, n. 1, p. 19-28, 2024.

- LI, Xing et al. Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Huanglian Jiedu Decoction against sepsis. Computers in biology and medicine, v. 144, p. 105389, 2022.

- JAWAD, Issrah; LUKŠIĆ, Ivana; RAFNSSON, Snorri Bjorn. Assessing available information on the burden of sepsis: global estimates of incidence, prevalence and mortality. Journal of global health, v. 2, n. 1, p. 010404, 2012.

- ZHANG, K. et al. Impaired long-term quality of life in survivors of severe sepsis. Anaesthesist, v. 62, n. 12, 2013.

- SHANKAR-HARI, Manu et al. Developing a new definition and assessing new clinical criteria for septic shock: for the third international consensus definitions for sepsis and septic shock (Sepsis-3). Jama, v. 315, n. 8, p. 775-787, 2016.

- REYNOLDS, Teri A. et al. Strengthening health systems to provide emergency care. Disease control priorities: improving health and reducing poverty, v. 3, 2017.

- SALES JÚNIOR, João Andrade L. et al. Sepse Brasil: estudo epidemiológico da sepse em unidades de terapia intensiva brasileiras. Revista Brasileira de Terapia Intensiva, v. 18, p. 9-17, 2006.

- CUTHBERTSON, Brian H. et al. Mortality and quality of life in the five years after severe sepsis. Critical Care, v. 17, p. 1-8, 2013.

- IWASHYNA, Theodore J. et al. Long-term cognitive impairment and functional disability among survivors of severe sepsis. Jama, v. 304, n. 16, p. 1787-1794, 2010.

- HARRINGTON, John S. et al. Mitochondria in health, disease, and aging. Physiological reviews, v. 103, n. 4, p. 2349-2422, 2023.

- GYAWALI, Bishal; RAMAKRISHNA, Karan; DHAMOON, Amit S. Sepsis: The evolution in definition, pathophysiology, and management. SAGE open medicine, v. 7, p. 2050312119835043, 2019.

- BEESLEY, Sarah J. et al. Septic cardiomyopathy. Critical care medicine, v. 46, n. 4, p. 625-634, 2018.

- RHODES, Andrew et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive care medicine, v. 43, p. 304-377, 2017.

- ROCHA, Leonardo Lima et al. Current concepts on hemodynamic support and therapy in septic shock. Brazilian Journal of Anesthesiology, v. 65, p. 395-402, 2015.

- JORGE, Raquel Liana Neves et al. Septic shock. Rev Med Minas Gerais, v. 26, n. 4, p. 9-12, 2016.

- CARVALHO, Renan Henrique de et al. Sepsis, severe sepsis and septic shock: clinical, epidemiological and prognostic aspects in patients in the Intensive Care Unit of a University Hospital. Journal of the Brazilian Society of Tropical Medicine, v. 43, p. 591-593, 2010.

- DE BACKER, Daniel et al. Dopamine versus norepinephrine in the treatment of septic shock: a meta-analysis. Critical care medicine, v. 40, n. 3, p. 725-730, 2012.

-DUGAR, Siddharth; CHOUDHARY, Chirag; DUGGAL, Abhijit. Sepsis and septic shock: Guideline-based management. Cleve Clin J Med, v. 87, n. 1, p. 53-64, 2020.

- HARJOLA, Veli‐Pekka et al. Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). European journal of heart failure, v. 19, n. 7, p. 821-836, 2017.

- ALASTRUEY, Jordi et al. Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet. American Journal of Physiology-Heart and Circulatory Physiology, v. 325, n. 1, p. H1-H29, 2023.

- DE BACKER, Daniel et al. How can assessing hemodynamics help to assess volume status?. Intensive care medicine, v. 48, n. 10, p. 1482-1494, 2022.

- INCE, Can. Hemodynamic coherence and the rationale for monitoring the microcirculation. Critical care, v. 19, n. Suppl 3, p. S8, 2015.

- NADIM, Mitra K. et al. Management of the critically ill patient with cirrhosis: a multidisciplinary perspective. Journal of hepatology, v. 64, n. 3, p. 717-735, 2016.

- PEAKE, Sandra L. et al. Goal-directed resuscitation for patients with early septic shock. The New England journal of medicine, v. 371, n. 16, p. 1496-1506, 2014.

- THOOFT, Aurélie et al. Effects of changes in arterial pressure on organ perfusion during septic shock. Critical Care, v. 15, p. 1-8, 2011.

- KALLIOINEN, Noa et al. Sources of inaccuracy in the measurement of adult patients’ resting blood pressure in clinical settings: a systematic review. Journal of hypertension, v. 35, n. 3, p. 421-441, 2017.

- BALZI, Ana Paula de Carvalho Canela et al. Can a therapeutic strategy for hypotension improve cerebral perfusion and oxygenation in an experimental model of hemorrhagic shock and severe traumatic brain injury?. Neurocritical care, v. 39, n. 2, p. 320-330, 2023.

- LIAO, Xinyi et al. Retrograde inferior vena cava perfusion reduces the risk of acute kidney injury depending on the oxygen extraction ratio. A retrospective cohort study. Frontiers in Cardiovascular Medicine, v. 12, p. 1514247, 2025.

- MOTAZEDIAN, Pouya et al. Central Venous Oxygen Saturation for Estimating Mixed Venous Oxygen Saturation and Cardiac Index in the ICU: A Systematic Review and Meta-Analysis. Critical care medicine, v. 52, n. 11, p. e568-e577, 2024.

- SAMHITHA, Chundi Sai; BORKAR, Rajendra. Role of Serial Estimation of Serum Lactate Levels to Predict the Outcome in Paediatric Shock. Annals of the Romanian Society for Cell Biology, v. 25, n. 1, p. 4006-4014, 2021.

- WEINBERGER, Jeremy; KLOMPAS, Michael; RHEE, Chanu. What is the utility of measuring lactate levels in patients with sepsis and septic shock?. In: Seminars in Respiratory and Critical Care Medicine. Thieme Medical Publishers, Inc., 2021.

- WANG, Ling et al. Intensive insulin therapy in sepsis patients: better data enables better intervention. Heliyon, v. 9, n. 3, 2023.

- MENG, Jiahao et al. Intensive or liberal glucose control in intensive care units for septic patients? A meta-analysis of randomized controlled trials. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, v. 18, n. 5, p. 103045, 2024.

- SCHMIDT, André P.; BILOTTA, Federico. Hydroxyethyl starch for perioperative fluid management: a critical appraisal. Brazilian Journal of Anesthesiology, v. 73, n. 5, p. 529-531, 2023.

- ADIGBLI, Derick et al. Intensive glucose control in critically ill adults: a protocol for a systematic review and individual patient data meta-analysis. Critical Care Science, v. 35, n. 4, p. 345-354, 2023.

- GARCÍA-ÁLVAREZ, Raquel; ARBOLEDA-SALAZAR, Rafael. Vasopressin in Sepsis and other Shock States: state of the art. Journal of Personalized Medicine, v. 13, n. 11, p. 1548, 2023.

- SACHA, Gretchen L.; BAUER, Seth R. Optimizing vasopressin use and initiation timing in septic shock: A narrative review. Chest, v. 164, n. 5, p. 1216-1227, 2023.

- RUSSELL, James A. et al. Vasopressor therapy in the intensive care unit. In: Seminars in respiratory and critical care medicine. Thieme Medical Publishers, Inc., 2021.

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Publicado

2025-07-31

Como Citar

Camarço Lima , M. S., Gonzalez Benítez , F. J., Moreira Parra , J. A., Fernandes, L. P., Bernardino Hashimoto, F., Caparroz, L., Soares Alvarenga, F. de A., dos Santos , V. G. M., Pernambuco Sachs , I. de A., Duarte Villela, G. B., Rodrigues , C., Agostinho Villarta , F. V., Laureano de Toledo, R., & Fernandes Roma, M. (2025). Atualizações em Suporte Hemodinâmico e Estratégias Terapêuticas no Choque Séptico. Brazilian Journal of Implantology and Health Sciences, 7(7), 1672–1686. https://doi.org/10.36557/2674-8169.2025v7n7p1672-1686