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A leucemia é caracterizada pelo acúmulo de células cancerígenas na medula óssea que substituem a celularidade sanguínea normal. Sua classificação depende da linhagem de células atingidas, sendo de origem mielóide ou linfóide, apresentam-se como leucemias agudas ou crônicas. Objetiva-se apresentar um painel de marcadores moleculares identificados nas leucemias linfóides e mielóides, através de uma revisão integrativa. Foram encontrados na base de dados Pubmed 512 artigos publicados em inglês entre os anos de 2015 e 2020. Após a submissão desses artigos aos critérios de inclusão e exclusão, foram eliminados 492 pesquisas, restando apenas 20. Os estudos demonstraram que os biomarcadores conseguem trazer uma melhor evolução do quadro do paciente, utilizando principalmente vias de sinalização para a inibição de alguns marcadores moleculares. Dessa forma, a utilização de biomarcadores no diagnóstico e prognóstico das leucemias, é de suma importância para o melhoramento do quadro clínico do paciente, diminuição da evolução da doença e menor recidivas de neoplasias hematológicas.
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Copyright (c) 2024 José Gabriel Santos de Almeida, Ana Beatriz Monteiro de Medeiros, Laíza Andrade Soares Diniz, Fernanda Eduarda das Neves Martins, João Vitor dos Santos Benjamin, Mateus Almeida Castro, Marcos Flávio Spínola Ambrósio , Robson Salaroli, Giovanna Ferreira Lopes , Maria Eduarda da Motta Fernandes Pagnoncelli, Benedito Leandro Francês de Castro, Aucelia Cristina Soares de Belchior, Lúcia Patrícia Bezerra Gomes da Silva