Palavras-chave
Regeneração óssea
Microtomografia de raios-x
Histologia
Como Citar
Resumo
Introdução: A utilização de substitutos ósseos em procedimentos de enxertia como alternativa ao uso de enxerto ósseo autógeno tem sido indicada, entretanto, a comparação direta entre esses biomateriais tem sido pouco explorada.
Objetivo: Avaliar o efeito de diferentes substitutos ósseos osteocondutores no reparo ósseo em defeitos de tamanho crítico (DAC) em calvária de ratos.
Material e método: Um DSC com diâmetro de 8 mm foi feito em cada um dos 40 ratos usados neste estudo. Os animais foram alocados aleatoriamente em 5 grupos (n = 8), de acordo com o tipo de substituto ósseo utilizado para o preenchimento do DSC: COA (Coágulo); AUT (osso autógeno); DBB (enxerto ósseo bovino desproteinizado); HA / TCP (cerâmica bifásica composta por hidroxiapatita e β-fosfato tricálcico); e TCP (β-fosfato tricálcico). Uma análise microtomográfica foi realizada para avaliar o comprimento linear do defeito remanescente (DLL) do DSC e o volume dos tecidos mineralizados (TM) dentro do DSC aos 3, 7, 15 e 30 dias após o procedimento cirúrgico. Além disso, foi realizada uma análise histométrica para avaliar a composição do tecido ósseo reparado (% Osso e% Biomaterial) no período de 30 dias.
Resultado: Foi demonstrado que o COA apresentou o menor DLL e MT dentro do CSD. Além disso, o COA apresentou o maior% de osso na DAG. O DBB apresentou maior MT e maior% de partículas de substituto ósseo no CSD do que os grupos AUT e TCP. Os grupos DBB e AUT apresentaram maior% de osso no DSC do que o grupo TCP.
Conclusão: O uso do DBB promoveu melhor padrão de ganho e formação de volume ósseo em relação ao TCP e HA / TCP, mas foi biologicamente inferior ao AUT.
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Este artigo é uma cópia com adaptação para o português do Artigo Original "Aroni, Mauricio Andrés Tinajero, et al. "Bone repair induced by different bone graft substitutes in critical-sized defects in rat calvaria." Revista de Odontologia da UNESP 48 (2019)." Esta Cópia com adaptação para o Português segue os preceitos Creative Commons CC BY 4.0 ( https://creativecommons.org/licenses/by/4.0/deed.pt_BR ) disponibilizado pelo periódico responsável pela publicação original ( https://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-25772019000100410 )
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Copyright (c) 2020 Mauricio Andrés Tinajero ARONI , Paulo Firmino da COSTA NETO , Guilherme José Pimentel Lopes de OLIVEIRA , Rosemary Adriana Chiérici MARCANTONI, Elcio MARCANTONIO JUNIOR