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Abstract
Introduction: Refractory epilepsy represents a challenge in neurology, affecting the quality of life of patients who do not respond to conventional pharmacological therapies. Vagus Nerve Stimulation (VNS) emerges as a promising approach. Methodology: This integrative review was based on 29 studies on VNS in the treatment of refractory epilepsy. The PICO strategy was used to construct the research question and articles were selected from databases such as MEDLINE/PubMed, Science Direct and LILACS. Results: VNS proved to be effective in reducing the frequency of epileptic seizures, with around 8% of patients achieving freedom from seizures. Side effects, such as headache and skin irritation, were mild and well tolerated. The therapy was especially beneficial for patients with specific epilepsy syndromes. However, the high cost of VNS can be a barrier for many patients. Conclusion: VNS is a safe and effective approach for the treatment of refractory epilepsy. Early intervention may be particularly beneficial, especially in pediatric patients. Future technological innovations could make ENV more accessible and effective.
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Copyright (c) 2023 Gustavo Fernandes do Vale, Leticia De Queiroz Cunha, Maria Clara Cardoso Felipe , Luiz Felipe De Azevedo Assunção, Maria Oitava Rosado Cantídio , Fernando Marinho Filho, Keren Suely Rocha Bezerra, Maria Beatriz Leandro Bezerra, Edson Jovino de Oliveira, Ana Larissa Fernandes de Holanda