Perspectivas Atuais e Futuras nas Abordagens Terapêuticas para Hipertensão Pulmonar Persistente Neonatal.

Abstract

Persistent Pulmonary Hypertension of the Newborn (PPHN) is a complex condition that represents a significant challenge in neonatology. This study reviews current therapeutic approaches for PPHN, with a focus on the efficacy and safety of sildenafil, an emerging and promising therapeutic option. An integrative review was carried out, covering articles, theses and dissertations available on scientific databases, considering the references indicated in Vancouver. Analysis of the sources included evaluation of relevance, methodology and results. Among the sources analyzed, studies such as Margotto et al. (2006), Miranda et al. (2014), and Yaseen et al. (2012) explored the efficacy of sildenafil in different clinical contexts. Carvalho et al. (2005) and Ferreira et al. (2018) highlighted the importance of correct diagnosis and the role of sildenafil in associated conditions. Rodrigues et al. (2008) and Magalhães et al. (2011) offered perspectives on etiopathogenesis and various therapeutic approaches. Sildenafil has emerged as a promising therapeutic alternative for NRHP, although more robust clinical studies are needed to validate its efficacy and safety in different clinical contexts. The ideal therapeutic approach should be individualized, taking into account the severity of the condition and other comorbidities. Interdisciplinary collaboration is vital to optimize the management of PPROM and improve outcomes for affected neonates.